{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:49:13Z","timestamp":1790804953676,"version":"4.1.0"},"reference-count":42,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Little is known about the impact of COVID-19 on mild cognitive disorder.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this retrospective cohort study was to investigate whether COVID-19 diagnosis is associated with subsequent mild cognitive disorder (MCD) compared to acute upper respiratory infections (AURI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study used data from the Disease Analyzer database (IQVIA) and included 67,046 patients with first-time symptomatic or asymptomatic COVID-19 diagnoses in 1,172 general practices in Germany between March 2020 and September 2021. Diagnoses were based on ICD-10 codes. Patients diagnosed with AURI were matched to 67,046 patients with COVID-19 using propensity scores based on sex, age, index month, and comorbidities. The index date was the diagnosis date for either COVID-19 or AURI. Associations between the COVID-19 and MCD were studied using conditional Poisson regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The incidence of MCD was 7.6 cases per 1,000 person-years in the COVID-19 group and 5.1 cases per 1,000 person-years in the AURI group (IRR\u200a=\u200a1.49, 95% CI\u200a=\u200a1.22\u20131.82). The incidence rate ratio decreased strongly with increasing age from 10.08 (95% CI\u200a=\u200a4.00\u201324.42) in the age group\u226450 to 1.03 (95% CI\u200a=\u200a0.81\u20131.31) in the age group\u200a&gt;\u200a70. In addition, the association between COVID-19 and MCD was significant in women (IRR: 1.70, 95% CI: 1.34\u20132.16) but not in men (IRR: 1.08, 95% CI: 0.75\u20131.56).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The incidence of MCD was low but significantly higher in COVID-19 than in AURI patients, especially among younger patients. If a cognitive disorder is suspected, referral to a specialist is recommended.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-220020","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T12:02:45Z","timestamp":1654257765000},"page":"297-305","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Mild Cognitive Disorder in Post-COVID-19 Syndrome: A Retrospective Cohort Study of 67,000 Primary Care Post-COVID Patients"],"prefix":"10.1177","volume":"6","author":[{"given":"Jens","family":"Bohlken","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Sozialmedizin, Arbeitsmedizin und Public Health (ISAP) der Medizinischen Fakult\u00e4t der Universit\u00e4t Leipzig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Weber","sequence":"additional","affiliation":[{"name":"Impfzentrum Messe 21, Berlin, 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