{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:12:54Z","timestamp":1777392774171,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>An 82-year-old right-handed man, a retired teacher, reported the occurrence, three years earlier, of difficulties in moving his left arm and foot, tremor in his left hand, and gestures of the left upper limb that appeared to be independent of the patient\u2019s will.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We describe an unusual case of corticobasal syndrome (CBS) showing disease-associated biomarkers of dementia with Lewy bodies (DLB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Clinical, neuropsychological, imaging, and biomarker evaluations were conducted, including tau and amyloid-\u03b2 levels in the cerebrospinal fluid (CSF) and a RT-QuIC assay for \u03b1-synuclein both in the CSF and olfactory mucosa (OM), as well as a QEEG assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The patient presented resting tremor, mild extrapyramidal hypertonus, mild bradykinesia on the left side, and severe apraxia on the left upper limb. Brain MRI showed a diffuse right hemisphere atrophy which was prominent in the posterior parietal and temporal cortices, and moderate in the frontal cortex and the precuneus area.\n                      <jats:sup>18<\/jats:sup>\n                      F-FDG PET imaging showed reduced glucose metabolism in the right lateral parietal, temporal, and frontal cortices with involvement of the right precuneus. The putamen did not appear to be pathological at DaTQUANT. Neuropsychological tests showed memory and visual-perceptual deficits. CSF tau and amyloid measurements did not show clear pathological values. RT-QuIC for \u03b1-synuclein in CSF and OM samples were positive. The QEEG analysis showed a pre-alpha dominant frequency in posterior derivations, typical of early stages of DLB.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although in the present patient the clinical diagnosis was of probable CBS, unexpectedly positive biomarkers for DLB suggested the co-presence of multiple pathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-220026","type":"journal-article","created":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T12:24:59Z","timestamp":1658838299000},"page":"431-442","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Patient with Corticobasal Syndrome Showing Disease-Associated Biomarkers of Dementia with Lewy Bodies: A Treviso Dementia (TREDEM) Registry Case Report"],"prefix":"10.1177","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6329-3195","authenticated-orcid":false,"given":"Maurizio","family":"Gallucci","sequence":"first","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"},{"name":"Associazione Alzheimer Treviso Onlus, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Grassivaro","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Da Ronch","sequence":"additional","affiliation":[{"name":"Cognitive Impairment Center, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Fiore","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico Marco","family":"Bonifati","sequence":"additional","affiliation":[{"name":"Neurology Unit, Local Health Authority n.2 MarcaTrevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Bendini","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Local Health Authority n.2 Marca Trevigiana, Treviso, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Zanusso","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Biomedicine and Movement, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Bonanni","sequence":"additional","affiliation":[{"name":"Department of Medicine and Aging Sciences, University G. d\u2019Annunzio of Chieti-Pescara, Chieti, 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