{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:11:39Z","timestamp":1777392699891,"version":"3.51.4"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) has several risk factors. APOE4 is the main one, and it has been suggested that there may be a synergy between it and BCHE-K as a risk factor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the association between APOE4 and BCHE-K as a risk factor for AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We searched PubMed, Web of Science, Embase, and Scopus on August 8, 2021 for studies that analyzed the association of APOE4 and BCHE-K with AD. The random effect model was performed in meta-analysis according to age group. A chi-square was performed with the meta-analysis data to verify if the effect found is not associated only with the E4 allele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Twenty-one studies with 6,853 subjects (3,528 AD and 3,325 Controls) were included in the meta-analysis. The quality of the evidence is moderate. There is a positive E4-K association for subjects with AD as shown by the odds ratio of 3.43. The chi-square meta test, which measures the probability that the E4-K association is due to chance, has an odds ratio of 6.155, indicating that the E4-K association is not a random event. The odds ratio of an E4-K association in subjects with AD increases to OR 4.46 for the 65- to 75-year-old group and OR 4.15 for subjects older than 75 years. The probability that the E4-K association is due to chance is ruled out by chi-square meta test values of OR 8.638 and OR 9.558.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The synergy between APOE4 and BCHE-K is a risk factor for late-onset AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-220084","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T13:14:02Z","timestamp":1686057242000},"page":"613-625","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Confirmed Synergy Between the \u025b4 Allele of Apolipoprotein E and the Variant K of Butyrylcholinesterase as a Risk Factor for Alzheimer\u2019s Disease: A Systematic Review and Meta-Analysis"],"prefix":"10.1177","volume":"7","author":[{"given":"Renan C.","family":"Ratis","sequence":"first","affiliation":[{"name":"Laboratory of Neurosciences and Behavior, Department of Pharmacy, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria I.","family":"Dacoregio","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiane P.","family":"Sim\u00e3o-Silva","sequence":"additional","affiliation":[{"name":"Post-Graduate Program in Intellectual Property and Technology Transfer for Innovation, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rog\u00e9rio P.","family":"Mateus","sequence":"additional","affiliation":[{"name":"Evolutionary Biology Laboratory, Department of Biology, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana P.B.","family":"Machado","sequence":"additional","affiliation":[{"name":"Evolutionary Biology Laboratory, Department of Biology, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5144-2253","authenticated-orcid":false,"given":"Juliana S.","family":"Bonini","sequence":"additional","affiliation":[{"name":"Laboratory of Neurosciences and Behavior, Department of Pharmacy, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weber Claudio Francisco Nunes da","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Neuropsychopharmacology, Department of Pharmacy, State University of the Midwest, Paran\u00e1, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.01.012"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2017.03.006"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.10.010"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2018.17.4.131"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1237-z"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.11.1933"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.062"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.2174\/1567205013666160404120542"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.11.011"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410360506"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/9780470640500.ch3"},{"key":"ref014","first-page":"1086","volume":"50","author":"Bartels CF","year":"1992","journal-title":"Am J Hum Genet"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050929"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050365"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2021.105906"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.3163\/1536-5050.98.2.021"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0384-4"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-019-1070-0"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12494"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7247.1468"},{"key":"ref024","unstructured":"Sch\u00fcnemannH, Bro\u017cekJ, GuyattG, OxmanA. 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