{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:21:32Z","timestamp":1790374892982,"version":"4.1.0"},"reference-count":71,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Apraxia of speech (AOS) is a core feature of nonfluent\/agrammatic primary progressive aphasia (naPPA), but its precise characteristics and the prevalence of AOS features in spontaneous speech are debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the frequency of features of AOS in the spontaneous, connected speech of individuals with naPPA and to evaluate whether these features are associated with an underlying motor disorder such as corticobasal syndrome or progressive supranuclear palsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We examined features of AOS in 30 patients with naPPA using a picture description task. We compared these patients to 22 individuals with behavioral variant frontotemporal dementia and 30 healthy controls. Each speech sample was evaluated perceptually for lengthened speech segments and quantitatively for speech sound distortions, pauses between and within words, and articulatory groping. We compared subgroups of naPPA with and without at least two features of AOS to assess the possible contribution of a motor impairment to speech production deficits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>naPPA patients produced both speech sound distortions and other speech sound errors. Speech segmentation was found in 27\/30 (90%) of individuals. Distortions were identified in 8\/30 (27%) of individuals, and other speech sound errors occurred in 18\/30 (60%) of individuals. Frequent articulatory groping was observed in 6\/30 (20%) of individuals. Lengthened segments were observed rarely. There were no differences in the frequencies of AOS features among naPPA subgroups as a function of extrapyramidal disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Features of AOS occur with varying frequency in the spontaneous speech of individuals with naPPA, independently of an underlying motor disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-220089","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T10:02:33Z","timestamp":1686304953000},"page":"589-604","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Apraxia of Speech in the Spontaneous Speech of Nonfluent\/Agrammatic Primary Progressive Aphasia"],"prefix":"10.1177","volume":"7","author":[{"given":"Sharon","family":"Ash","sequence":"first","affiliation":[{"name":"Penn Frontotemporal Degeneration Center and Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi","family":"Nevler","sequence":"additional","affiliation":[{"name":"Penn Frontotemporal Degeneration Center and Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Penn Frontotemporal Degeneration Center and Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjana","family":"Shellikeri","sequence":"additional","affiliation":[{"name":"Penn Frontotemporal Degeneration Center and Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rascovsky","sequence":"additional","affiliation":[{"name":"Penn Frontotemporal Degeneration Center and Department of Neurology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Q.","family":"Trojanowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murray","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"ref001","unstructured":"DarleyFL, AronsonAE, BrownJR (1975) Motor Speech Disorders, Saunders, Philadelphia."},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws032"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1044\/2015_AJSLP-14-0174"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu223"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1044\/2018_AJSLP-17-0227"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.02.036"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2020.1765307"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2020.1765306"},{"key":"ref010","unstructured":"McNeilMR, RobinDA, SchmidtRA (1997) Apraxia of speech: Definition, differentiation, and treatment. 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