{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:38:33Z","timestamp":1789180713159,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,15]],"date-time":"2023-07-15T00:00:00Z","timestamp":1689379200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:p>Weight changes, neuropsychiatric symptoms (NPS), and cognitive decline often coincide in Alzheimer\u2019s disease (AD) and frontotemporal dementia (FTD); however, the direction of their relationship remains unclear. This study aims to clarify the connection between weight changes, NPS, and cognition in AD and FTD. We found that cognitive decline was associated with decreased body mass index (BMI) in AD, while BMI gain was associated with increased conversion to FTD. Elevated NPS were associated with decreased BMI in AD and increased BMI in FTD. Identifying early changes in NPS and BMI may facilitate the detection of cognitive decline, providing an opportunity for early intervention.<\/jats:p>","DOI":"10.3233\/adr-230034","type":"journal-article","created":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T11:25:04Z","timestamp":1689679504000},"page":"767-774","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Weight Change and Neuropsychiatric Symptoms in Alzheimer\u2019s Disease and Frontotemporal Dementia: Associations with Cognitive Decline"],"prefix":"10.1177","volume":"7","author":[{"given":"Christopher B.","family":"Morrow","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Leoutsakos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiadi","family":"Onyike","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidyulata","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,7,15]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12525"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1159\/000360415"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.4756"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5659"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.73.4.371"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.728108"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220443"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1097\/01.wad.0000213865.09806.92"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318142774e"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0b013e318191c7dd"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.11.2412-a"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4679(197701)33:1+<208::AID-JCLP2270330146>3.0.CO;2-E"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1177\/1073191115602552"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200803"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.021275"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200739"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210179"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.2.233"},{"key":"ref021","first-page":"555","volume":"45","author":"Albinski R","year":"2011","journal-title":"Psychiatr Pol"},{"key":"ref022","first-page":"38","volume":"11","author":"Gillette Guyonnet S","year":"2007","journal-title":"J Nutr Health Aging"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.014"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.6.1585"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.61.5.668"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617713001409"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2015.09.004"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112002753"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(04)00878-6"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.3109\/09687689509038508"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1016\/j.gerinurse.2005.01.009"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.12.004"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1836"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00380-4"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000277461.06713.23"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002018"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-819973-2.00019-8"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000106"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101491"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00886-5"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101941"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01942-9"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e31824b211b"},{"key":"ref044","first-page":"1","volume":"70","author":"Heron M","year":"2021","journal-title":"Natl Vital Stat Rep"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR-230034","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:30Z","timestamp":1777370250000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR-230034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,15]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.3233\/ADR-230034"],"URL":"https:\/\/doi.org\/10.3233\/adr-230034","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,15]]}}}