{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:35:33Z","timestamp":1791531333293,"version":"4.3.4"},"reference-count":63,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Alzheimer\u2019s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are typically associated with very different clinical and neuroanatomical presentations; however, there is increasing recognition of similarities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To examine memory and executive functions, as well as cortical thickness, and glucose metabolism in AD and bvFTD signature brain regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We compared differences in a group of biomarker-defined participants with Alzheimer\u2019s disease and a group of clinically diagnosed participants with bvFTD. These groups were also contrasted with healthy controls (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>As expected, memory functions were generally more impaired in AD, followed by bvFTD, and both clinical groups performed more poorly than the HC group. Executive function measures were similar in AD compared to bvFTD for motor sequencing and go\/no-go, but bvFTD had more difficulty with a set shifting task. Participants with AD showed thinner cortex and lower glucose metabolism in the angular gyrus compared to bvFTD. Participants with bvFTD had thinner cortex in the insula and temporal pole relative to AD and healthy controls, but otherwise the two clinical groups were similar for other frontal and temporal signature regions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Overall, the results of this study highlight more similarities than differences between AD and bvFTD in terms of cognitive functions, cortical thickness, and glucose metabolism. Further research is needed to better understand the mechanisms mediating this overlap and how these relationships evolve longitudinally.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-230049","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T11:34:40Z","timestamp":1705664080000},"page":"57-73","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["More Similar than Different: Memory, Executive Functions, Cortical Thickness, and Glucose Metabolism in Biomarker-Positive Alzheimer\u2019s Disease and Behavioral Variant Frontotemporal Dementia"],"prefix":"10.1177","volume":"8","author":[{"given":"Cierra M.","family":"Keith","sequence":"first","affiliation":[{"name":"Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc W.","family":"Haut","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA"},{"name":"Department of Neurology, West Virginia University, Morgantown, WV, USA"},{"name":"Department of Radiology, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"D\u2019Haese","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashi I.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, West Virginia University, Morgantown, WV, USA"},{"name":"Department of Radiology, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Vieira Ligo Teixeira","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Coleman","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Behavioral Medicine and Psychiatry, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ward","sequence":"additional","affiliation":[{"name":"Department of Neurology, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Osvaldo","family":"Navia","sequence":"additional","affiliation":[{"name":"Department of Medicine, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Marano","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, West Virginia University, Morgantown, WV, USA"},{"name":"Department of Radiology, West Virginia University, Morgantown, WV, USA"},{"name":"Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"McCuddy","sequence":"additional","affiliation":[{"name":"Department of 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