{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:16:41Z","timestamp":1777393001236,"version":"3.51.4"},"reference-count":60,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:00:00Z","timestamp":1690416000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Neurological disorders, such as Alzheimer\u2019s disease (AD), comprise a major cause of health-related disabilities in human. However, biomarkers towards pathogenesis or novel targets are still limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To identify the causality between plasma proteins and the risk of AD and other eight common neurological diseases using a Mendelian randomization (MR) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Exposure data were obtained from a genome-wide association study (GWAS) of 2,994 plasma proteins in 3,301 healthy adults, and outcome datasets included GWAS summary statistics of nine neurological disorders. Inverse variance-weighted MR method as the primary analysis was used to estimate causal effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Higher genetically proxied plasma myeloid cell surface antigen CD33 level was found to be associated with increased risk of AD (odds ratio [OR] 1.079, 95% confidence interval [CI] 1.047\u20131.112, p\u200a=\u200a8.39\u00d710\n                      <jats:sup>-7<\/jats:sup>\n                      ). We also discovered the causality between genetically proxied elevated prolactin and higher risk of epilepsy (OR\u200a=\u200a1.068, 95% CI\u200a=\u200a1.034\u20131.102; p\u200a=\u200a5.46\u00d710\n                      <jats:sup>-5<\/jats:sup>\n                      ). Negative associations were identified between cyclin-dependent kinase 8 and ischemic stroke (OR\u200a=\u200a0.927, 95% CI\u200a=\u200a0.896\u20130.959, p\u200a=\u200a9.32\u00d710\n                      <jats:sup>-6<\/jats:sup>\n                      ), between neuralized E3 ubiquitin-protein ligase 1 and migraine (OR\u200a=\u200a0.914, 95% CI\u200a=\u200a0.878\u20130.952, p\u200a=\u200a1.48\u00d710\n                      <jats:sup>-5<\/jats:sup>\n                      ), and between Fc receptor-like protein 4 and multiple sclerosis (MS) (OR\u200a=\u200a0.929, 95% CI\u200a=\u200a0.897\u20130.963, p\u200a=\u200a4.27\u00d710\n                      <jats:sup>-5<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The findings identified MR-level protein-disease associations for AD, epilepsy, ischemic stroke, migraine, and MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-230058","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:08:18Z","timestamp":1690546098000},"page":"811-822","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Identifying Suitable Targets for Alzheimer\u2019s Disease and Other Eight Common Neurological Disorders Using the Human Plasma Proteome: A Mendelian Randomization Study"],"prefix":"10.1177","volume":"7","author":[{"given":"Tao","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolei","family":"Shi","sequence":"additional","affiliation":[{"name":"Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China"},{"name":"Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Neurology, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiyi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaojiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological Disorders, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, National Center for Neurological 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