{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:07:09Z","timestamp":1792260429603,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Dementia with Lewy bodies (DLB) is a progressive neurodegenerative disease with various clinical symptoms. Limited data have described the clinical subtypes of DLB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to compare clinical subtypes of DLB according to initial symptoms and to study the effect of Apolipoprotein E ( APOE) gene in DLB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We included DLB patients classified into three groups based on initial symptoms: non-motor onset (cognitive and\/or psychiatric) (NMO-DLB), motor onset (parkinsonism and\/or gait disorders) (MO-DLB), and mixed onset (non-motor and motor symptoms) (MXO-DLB). Clinical and APOE genotype associations and survival were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 268 patients were included (NMO-DLB = 75%, MXO-DLB = 15.3%, MO-DLB = 9.7%). Visual hallucinations were more frequent ( p = 0.025), and attention was less commonly impaired in MXO-DLB ( p = 0.047). When adjusting with APOE \u025b4 status ( APOE genotype performed in 155 patients), earlier falls and frontal lobe syndrome were more common in MXO-DLB ( p = 0.044 and p = 0.023, respectively). The median MMSE decline was 2.1 points\/year and the median FAB decline was 1.9 points\/year, with no effect of clinical subtypes. Median survival was 6 years. It was similar in DLB subtypes ( p = 0.62), but shorter for patients with memory symptoms at onset ( p = 0.04) and for males ( p = 0.0058).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our study revealed a few differences between DLB clinical subtypes. APOE \u025b4 appears to be associated with earlier falls and a higher prevalence of frontal syndrome in MXO-DLB. However, DLB clinical subtypes did not impact on survival. Nevertheless, survival analysis identified other poor prognosis factors, notably inaugural memory impairment and male gender.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-230064","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T11:36:55Z","timestamp":1701171415000},"page":"1277-1288","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Subtypes of Dementia with Lewy Bodies: Clinical Features, Survival, and Apolipoprotein E Effect"],"prefix":"10.1177","volume":"7","author":[{"given":"Alya","family":"Gharbi","sequence":"first","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Nasri","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikram","family":"Sghaier","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Kacem","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloua","family":"Mrabet","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Souissi","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mouna","family":"Ben Djebara","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amina","family":"Gargouri","sequence":"additional","affiliation":[{"name":"Neurology Department, Razi University Hospital, Tunis, Tunisia"},{"name":"Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia"},{"name":"Clinical Investigation Center (CIC) \u201cNeurosciences and Mental Health\u201d, Razi University Hospital, Tunis, 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