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The current gold standard diagnostic methods have limitations of being invasive, costly, and not easily accessible. Thus, there is a need for new avenues, such as imaging the retina for early AD diagnosis. Sleep disruption is symptomatically frequent across preclinical and AD subjects. As circadian activity, such as the sleep-wake cycle, is linked to the retina, analysis of their association may be useful additions for achieving predictive AD diagnosis. In this narrative review, we provide an overview of human retina studies concerning the deposition of A\u03b2, the role of the retina in sleep-wake cycle, the disruption of sleep in AD, and to gather evidence for the associations between A\u03b2, the retina, and sleep. Understanding the mechanisms behind the associations between A\u03b2, retina, and sleep could assist in the interpretation of retinal changes accurately in AD.<\/jats:p>","DOI":"10.3233\/adr-230150","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T11:34:07Z","timestamp":1719315247000},"page":"1009-1021","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["The Crosstalk Between Amyloid-\u03b2, Retina, and Sleep for the Early Diagnosis of Alzheimer\u2019s Disease: A Narrative Review"],"prefix":"10.1177","volume":"8","author":[{"given":"Isaiah-Lorenzo","family":"De Guia","sequence":"first","affiliation":[{"name":"Macquarie University, North Ryde, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Eslick","sequence":"additional","affiliation":[{"name":"Macquarie University, North Ryde, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Naismith","sequence":"additional","affiliation":[{"name":"Faculty of Science, Charles Perkins Centre, The University of Sydney, Camperdown, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi","family":"Kanduri","sequence":"additional","affiliation":[{"name":"Macquarie University, North Ryde, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tejal M.","family":"Shah","sequence":"additional","affiliation":[{"name":"Macquarie University, North Ryde, NSW, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[{"name":"Macquarie University, North Ryde, NSW, Australia"},{"name":"Edith Cowen University, Joondalup, WA, Australia"},{"name":"Australian Alzheimer\u2019s Research Foundation, Nedlands, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref001","unstructured":"Government A (2023)\n                      Dementia in Australia\n                      . 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