{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:13:52Z","timestamp":1777392832463,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:p>The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent\/agrammatic subtype, and are exceptionally rare in the logopenic variant (lvPPA). Here we report a case of a 63-year-old man presenting as language impairment, predominantly naming and word-finding difficulties, emerged alongside a left-sided internal tremor. Neurological examination revealed bilateral, left-side predominant rigidity, bradykinesia, and resting tremor. Notably, anosmia and constipation were present. Language assessments showed preserved single-word comprehension, object knowledge, and a minimal apraxia of speech, as well as sentence repetition issues. Neuroimaging and biomarker analysis supported a diagnosis of primary progressive logopenic aphasia with amyloid pathology co-existing with prominent and early parkinsonism. This case underlines the intricate relationship between language disorders, parkinsonism, and amyloid pathology in lvPPA.<\/jats:p>","DOI":"10.3233\/adr-230168","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T11:34:10Z","timestamp":1719315250000},"page":"1023-1030","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Coexisting Logopenic Variant of Primary Progressive Aphasia with Amyloid Pathology and Early Parkinsonism"],"prefix":"10.1177","volume":"8","author":[{"given":"Martina","family":"Caccamo","sequence":"first","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Department of Translational Biomedicine and Neurosciences, Neurology Unit, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Urso","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Department of Neurosciences, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo Gabriele","family":"Nanni","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Department of Translational Biomedicine and Neurosciences, Neurology Unit, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Gnoni","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Department of Neurosciences, King\u2019s College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessia","family":"Giugno","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Vitulli","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Vilella","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Zecca","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Dell\u2019Abate","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Anastasia","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Pia Fondazione di Culto e Religione \u201cCard.G.Panico\u201d, Tricase, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"De Blasi","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Introna","sequence":"additional","affiliation":[{"name":"Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Logroscino","sequence":"additional","affiliation":[{"name":"Department of Clinical Research in Neurology, Center for Neurodegenerative Diseases and the Aging Brain, University of Bari \u2018Aldo Moro\u2019, \u201cPia Fondazione Cardinale G. Panico\u201d, Tricase, Lecce, Italy"},{"name":"Department of Translational Biomedicine and Neurosciences, Neurology Unit, Bari, Italy"},{"name":"Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari Aldo Moro, Bari, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00692"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012174"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25333"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-190158"},{"key":"ref006","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.nrl.2014.01.007","volume":"30","author":"Mat\u00edas-Guiu JA","year":"2015","journal-title":"Neurologia"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01150-0"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3001-y"},{"key":"ref009","unstructured":"MiceliG, LaudannaC, BuraniC, CaparroR (1994)\n                      Batteria per l\u2019analisi dei deficit afasici (B.A.D.A),\n                      CEPSAG, Universit\u00e0 Cattolica del Sacro Cuore, Roma."},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcomdis.2014.06.008"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1044\/2022_AJSLP-22-00148"},{"key":"ref012","volume-title":"Esame Neuropsicologico per l\u2019Afasia: ENPA","author":"Capasso R","year":"2001"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1044\/2019_AJSLP-CAC48-18-0225"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32833fb93e"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062471"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24885"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370306"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.37.5.754"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1159\/000064925"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.47.5.1113"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200567"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26424"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827f0fd1"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26987"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR-230168","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:52Z","timestamp":1777370272000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR-230168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,9]]}},"alternative-id":["10.3233\/ADR-230168"],"URL":"https:\/\/doi.org\/10.3233\/adr-230168","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}