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Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expression and none showed TDP-43 inclusions. What genetic and\/or environmental factors protect macaques from expressing more severe human neuro-pathologies remains an interesting unresolved question.<\/jats:p>","DOI":"10.3233\/adr-230184","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T11:56:14Z","timestamp":1704801374000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Pathological Markers of Alzheimer\u2019s Disease and Related Dementia in the Rhesus Macaque Amygdala"],"prefix":"10.1177","volume":"8","author":[{"given":"Jeremy L.","family":"Thomas","sequence":"first","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin I.","family":"Nilaver","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Lomniczi","sequence":"additional","affiliation":[{"name":"Department of Physiology & Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald I.","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"},{"name":"Facultad de Ciencias, Universidad de Valpara\u00edso, Valpara\u00edso, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria-Luisa","family":"Appleman","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven G.","family":"Kohama","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henryk F.","family":"Urbanski","sequence":"additional","affiliation":[{"name":"Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR, USA"},{"name":"Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0687-6"},{"key":"ref002","first-page":"866","volume":"21","author":"Jack CR","year":"2022","journal-title":"Neurol"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-322983"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.190884"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02524-2"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-023-02580-2"},{"key":"ref007","first-page":"1142617","volume":"15","author":"Nilaver BI","year":"2023","journal-title":"FrontAging Neurosci"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.106.051839"},{"key":"ref009","unstructured":"MessaoudiI, UrbanskiHF, KohamaSG(2011) Integrative models of aging in the nonhuman primate. 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