{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:44:47Z","timestamp":1788817487612,"version":"build-2803163510"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>In comparison to persons who did not have viral encephalitis, people with viral encephalitis had a later-life risk of Alzheimer\u2019s disease (AD) that was 31 times higher. In a previous study, we were able to confirm the association of viral encephalitis with AD and suggest that West Nile Virus infection is a significant AD risk factor. A genome wide association study (GWAS) with UK Biobank data revealed that the gene RAR Related Orphan Receptor B (RORB) is significantly associated with viral encephalitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To use data from the 8 PheWeb datasets to try to identify genes other than RORB that might be involved in both infectious encephalitis and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>PheWeb includes data from UKBB and 5 other databanks. We used UK Biobank data to examine gene expression and phenotypic expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>PheWeb identified additional genes associated with both infectious encephalitis and AD. RPTOR, a gene associated with the mTOR pathway, emerges as significant. Analyses of UK Biobank data reveal the impact of RPTOR on AD risk, with carriers of the minor allele A exhibiting decreased prevalence in subjects under age 55. Further analysis demonstrates that RPTOR genotypes influence body mass index (BMI) in subjects of all ages, with carriers of the minor allele A having lower BMI. Logistic regression analyses confirm the association between reduced BMI and increased AD risk, along with the established factor of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>RPTOR may represent an AD gene, though mTOR\u2019s role in AD and BMI is complex. Nevertheless, RPTOR and mTOR could represent potential therapeutic targets for AD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-230185","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T12:52:16Z","timestamp":1713531136000},"page":"715-721","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["RPTOR Is an Alzheimer\u2019s Disease Susceptibility Gene Associated with the Risk Factors Body Mass Index and Infectious Encephalitis"],"prefix":"10.1177","volume":"8","author":[{"given":"Steven","family":"Lehrer","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter H.","family":"Rheinstein","sequence":"additional","affiliation":[{"name":"Severn Health Solutions, Severna Park, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,18]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.12.029"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-023-00181-3"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMo020128"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2023.107984"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00764-7"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.80"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05473-8"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1119708"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0622-5"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12015"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu188"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1186\/1880-6805-33-38"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1134\/S1022795421050136"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.26162"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1186\/s13742-015-0047-8"},{"key":"ref016","unstructured":"ZhuA, SalminenLE, ThompsonPM, JahanshadN(2019) The UK Biobank Data Parser: A tool with built in and customizable filters for brain studies. Organization for Human Brain Mapping, Rome, Italy, June 9-13, 2019."},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq419"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra030476"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2324"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0320-z"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.628541"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3390\/v8060152"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.4300\/JGME-D-12-00156.1"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-010-0153-z"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12629"},{"key":"ref026","first-page":"1299","volume":"86","author":"Xu W","year":"2015","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00143-15"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-018-9821-6"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.07.007"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01140-2"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230185","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR-230185","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR-230185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:54Z","timestamp":1777370274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR-230185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,9]]}},"alternative-id":["10.3233\/ADR-230185"],"URL":"https:\/\/doi.org\/10.3233\/adr-230185","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]}}}