{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:07:10Z","timestamp":1784189230060,"version":"3.55.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Age-related neuronal changes impact cognitive integrity, which is a major contributor to health and quality of life. The best strategy to prevent cognitive decline and Alzheimer\u2019s disease is still debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To investigate the long-term effects of the eight-week multicomponent training program BrainProtect\n                      <jats:sup>\u00ae<\/jats:sup>\n                      on cognitive abilities compared to general health counseling (GHC) in cognitively healthy adults in Germany.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Healthy adults (age \u226550 years) previously randomized to either GHC ( n\u200a=\u200a72) or BrainProtect (intervention group, IG, n\u200a=\u200a60) for eight-weeks (once weekly, 90 minutes, group-based) underwent a comprehensive neuropsychological test battery and health-related quality of life (HRQoL) evaluation 3- and 12-months after intervention end.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Dropout rates were n\u200a=\u200a8 after 3 months and n\u200a=\u200a19 after 12 months. No significant long-term effect of BrainProtect was observed for the primary endpoint Consortium to Establish a Registry for Alzheimer\u2019s Disease (CERAD-Plus) total score. Logical reasoning was significantly improved ( p\u200a=\u200a0.024) 12 months after completion of the training program in IG participants compared to the GHC group independent of sex, age, education, diet, and physical activity. In IG participants, thinking flexibility ( p\u200a=\u200a0.019) and confrontational naming ( p\u200a=\u200a0.010) were improved 3 months after completing the intervention compared to the GHC group, however, after conservative Bonferroni adjustment, significance was lost.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      BrainProtect\n                      <jats:sup>\u00ae<\/jats:sup>\n                      independently improved logical reasoning compared to GHC up to 12 months after cognitive training\u2019s end in healthy adults. To uncover the long-term clinical significance of multicomponent cognitive training in healthy adults, studies with larger sample size and frequent follow up visits are necessary.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-230199","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:43:00Z","timestamp":1721389380000},"page":"1069-1087","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Long-Term Effects of the Multicomponent Program BrainProtect\n                    <sup>\u00ae<\/sup>\n                    on Cognitive Function: One-Year Follow-Up in Healthy Adults"],"prefix":"10.1177","volume":"8","author":[{"given":"Michelle Celine","family":"Kunkler","sequence":"first","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Maria","family":"Falkenreck","sequence":"additional","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Ophey","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology | Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Interventions (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Dencker","sequence":"additional","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Friese","sequence":"additional","affiliation":[{"name":"AF Gehirntraining, Bedburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Jahr","sequence":"additional","affiliation":[{"name":"C Plus, Krefeld, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Kalbe","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology | Neuropsychology and Gender Studies & Center for Neuropsychological Diagnostics and Interventions (CeNDI), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon","family":"Nelles","sequence":"additional","affiliation":[{"name":"Neuromed-Campus Hohenlind, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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