{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:52:19Z","timestamp":1789275139752,"version":"build-2803163510"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2024,1,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The evidence supporting the effectiveness of combined interventions in Alzheimer\u2019s disease (AD) patients remains inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the mid- and long-term effectiveness of physical training, alone or combined with cognitive games, on cognitive performance in patients with moderate AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Seventy-nine AD patients (\u224873% females, age of \u224870\u00b11 years) were randomly divided into three groups: aerobic-based training (AT-group, n\u200a=\u200a27), aerobic-based training plus cognitive games (ACT-group, n\u200a=\u200a25), and a control group engaged in reading (CG, n\u200a=\u200a26), two sessions per week. Cognitive performance was evaluated at the start, 4th week (W4), end of the 8th week (W8), and after a 4-week detraining period (W12), using problem-solving (Tower-of-Hanoi), selective attention (Stroop-test), and working memory (Digit-Span-test) assessments. Stress levels and quality of life were also evaluated. Results: Aerobic and combined training induced a positive effect on all cognitive functions tested at W4 (except problem-solving) and W8 (all p\u200a&lt;\u200a0.001) with greater improvements in working-memory and problem-solving in ACT-group ( p\u200a&lt;\u200a0.05). Depression levels also decreased significantly, and quality of life improved at W8 ( p\u200a&lt;\u200a0.001) in both groups. After 4 weeks of detraining, the beneficial effect of AT and ACT was still observed. The CG did not show any significant improvements at all time points. Conclusions: Physical and cognitive interventions appear effective for improving cognitive-functions, quality-of-life, and reducing depression in AD patients. Combined training emerges as a more effective strategy to mitigate AD progression. Further research is necessary to validate these results and explore their potential for preventing early cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr-249003","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T05:49:50Z","timestamp":1734587390000},"page":"833-845","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Effectiveness of Simultaneous Combined Intervention for Enhancing Cognitive Function in Patients with Moderate Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Ines","family":"Ben Ayed","sequence":"first","affiliation":[{"name":"Research Laboratory, Exercise Physiology and Physiopathology: from Integrated to Molecular \u201cBiology, Medicine and Health\u201d, LR19ES09, Faculty of Medicine of Sousse, Sousse University, Sousse, Tunisia"},{"name":"Laboratory of Human and Artificial Cognition (EA 4004), Psychology UFR, University of Vin-cennes\/Saint-Denis, Saint-Denis, France"},{"name":"Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achraf","family":"Ammar","sequence":"additional","affiliation":[{"name":"Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany"},{"name":"Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia"},{"name":"High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirine","family":"Aouichaoui","sequence":"additional","affiliation":[{"name":"Research Laboratory, Exercise Physiology and Physiopathology: from Integrated to Molecular \u201cBiology, Medicine and Health\u201d, LR19ES09, Faculty of Medicine of Sousse, Sousse University, Sousse, Tunisia"},{"name":"High Institute of Sport and Physical Education of Ksar Sa\u00efd, University of Manouba, Cit\u00e9 Nasr, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Naija","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital Sahloul Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Ben Amor","sequence":"additional","affiliation":[{"name":"Neurology Department, University Hospital Sahloul Sousse, Sousse, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan M.","family":"Glenn","sequence":"additional","affiliation":[{"name":"Department of Health, Exercise Science Research Center Human Performance and Recreation, University of Arkansas, Fayetteville, AR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamdi","family":"Chtourou","sequence":"additional","affiliation":[{"name":"High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia"},{"name":"Research Unit, Physical Activity, Sport, and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitham","family":"Jahrami","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Trabelsi","sequence":"additional","affiliation":[{"name":"Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia"},{"name":"High Institute of Sport and Physical Education of Sfax, University of Sfax, 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