{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:12:49Z","timestamp":1777392769307,"version":"3.51.4"},"reference-count":58,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,3,22]],"date-time":"2023-03-22T00:00:00Z","timestamp":1679443200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer's Disease Reports"],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Patients with subjective cognitive decline (SCD) report memory deterioration and are at an increased risk of converting to Alzheimer\u2019s disease (AD) although psychophysical testing does not reveal any cognitive deficit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Here, gustatory function is investigated as a potential predictor for an increased risk of progressive cognitive decline indicating higher AD risk in SCD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Measures of smell and taste perception as well as neuropsychological data were assessed in patients with subjective cognitive decline (SCD): Subgroups with an increased likelihood of the progression to preclinical AD (SCD+) and those with a lower likelihood (SCD\u2013) were compared to healthy controls (HC), patients with mild cognitive impairment and AD patients. The Sniffin\u2019 Sticks test contained 12 items with different qualities and taste was measured with 32 taste stripes (sweet, salty, bitter, sour) of different concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Only taste was able to distinguish between HC\/SCD\u2013 and SCD+ patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study provides a first hint of taste as a more sensitive marker than smell for detecting preclinical AD in SCD. Longitudinal observation of cognition and pathology are necessary to further evaluate taste perception as a predictor of pathological objective decline in cognition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/adr220092","type":"journal-article","created":{"date-parts":[[2023,3,24]],"date-time":"2023-03-24T12:24:20Z","timestamp":1679660660000},"page":"249-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["The Potential Role of Gustatory Function as an Early Diagnostic Marker for the Risk of Alzheimer\u2019s Disease in Subjective Cognitive Decline"],"prefix":"10.1177","volume":"7","author":[{"given":"Marlen","family":"Schmicker","sequence":"first","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Insa","family":"Fr\u00fchling","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"},{"name":"Medical Faculty, Otto von Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inga","family":"Menze","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research, Otto von Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenzel","family":"Glanz","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"},{"name":"Medical Faculty, Otto von Guericke University, Magdeburg, Germany"},{"name":"University Clinic for Cardiology and Angiology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany"},{"name":"Center for Intervention and Research on adaptive and maladaptive brain Circuits underlying mental health (C-I-R-C)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toemme","family":"Noesselt","sequence":"additional","affiliation":[{"name":"Biological Psychology, Faculty of Natural Science, Otto von Guericke University, Magdeburg, Germany"},{"name":"Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Notger G.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany"},{"name":"Medical Faculty, Otto von Guericke University, Magdeburg, Germany"},{"name":"Research Group Degenerative and Chronic Diseases, Movement, Faculty of Health Sciences Brandenburg, University of Potsdam, Potsdam, Germany"},{"name":"Center for Behavioral Brain Sciences, Otto von Guericke University, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,3,22]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.05.018"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.56.3.303"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.008"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30368-0"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-014-0490-8"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.10.003"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160407"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009216"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30159-X"},{"key":"ref012","first-page":"Doc01","volume":"9","author":"Fletcher LCB","year":"2013","journal-title":"GMS Health Technol Assess"},{"key":"ref013","first-page":"265","volume":"25","author":"Attems J","year":"2006","journal-title":"Clin Neuropathol"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23365"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09561-0"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90014-Q"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.148.3.357"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5300-6"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2008.09.008"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201168"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610218001114"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00240"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.18.2307"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5763-5"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00050.2004"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1080\/01639360802261862"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2006.05.020"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90023-S"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610214000532"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2014.01.003"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1177\/1533317518782173"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2016.06.010"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.3758\/BF03193146"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2004.01380.x"},{"key":"ref035","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.4.609"},{"key":"ref037","first-page":"709","volume":"24","author":"Yesavage JA","year":"1988","journal-title":"Psychopharmacol Bull"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-0088-y"},{"key":"ref040","first-page":"2","volume":"41","author":"Mueller C","year":"2003","journal-title":"Rhinology"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001015"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(01)00337-2"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2003.10.004"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10669"},{"key":"ref045","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.584863"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64196-0.00015-7"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.12.4.493"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000234032.77541.a2"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbz120"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2478-18.2019"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-8-S3-S5"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.1590\/1980-57642020dn14-030007"},{"key":"ref053","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12336"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00361-6"},{"key":"ref055","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000295996.54210.69"},{"key":"ref056","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2589276"},{"key":"ref057","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13005"},{"key":"ref058","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100981"}],"container-title":["Journal of Alzheimer's Disease Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR220092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/ADR220092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/ADR220092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:57:38Z","timestamp":1777370258000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/ADR220092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,22]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,11,1]]}},"alternative-id":["10.3233\/ADR220092"],"URL":"https:\/\/doi.org\/10.3233\/adr220092","relation":{},"ISSN":["2542-4823","2542-4823"],"issn-type":[{"value":"2542-4823","type":"print"},{"value":"2542-4823","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,22]]}}}