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The management of breast cancer has changed radically in the last 15 years due to significant advances in our understanding of these tumours. This knowledge has brought with it a major impact regarding surgical and systemic management and has been practice-changing, but it has also created significant uncertainties regarding how best integrate the radiotherapy treatment into the therapeutic scheme. In parallel, radiotherapy itself has also experienced major advances, new radiobiological concepts have emerged, and genomic data and other patient-specific factors must now be integrated into individualised treatment approaches. In this context, \u201cprecision medicine\u201d seeks to provide an answer to these open questions and uncertainties. The aim of the present review is to clarify the meaning of this term and to critically evaluate its role and impact on contemporary breast cancer radiotherapy.<\/jats:p>","DOI":"10.3233\/bd-201022","type":"journal-article","created":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T23:41:14Z","timestamp":1612741274000},"page":"1-16","source":"Crossref","is-referenced-by-count":3,"title":["Breast cancer radiotherapy: What physicians need to know in the era of the precision medicine"],"prefix":"10.1177","volume":"40","author":[{"given":"Ana Aurora","family":"D\u00edaz-Gavela","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Quir\u00f3nsalud Madrid, , Spain"},{"name":", Hospital La Luz, , Spain"},{"name":", Universidad Europea, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elia","family":"del Cerro Pe\u00f1alver","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Quir\u00f3nsalud Madrid, , Spain"},{"name":", Hospital La Luz, , Spain"},{"name":", Universidad Europea, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Sanchez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Quir\u00f3nsalud Madrid, , Spain"},{"name":", Hospital La Luz, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Leonardo Guerrero","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Quir\u00f3nsalud Madrid, , Spain"},{"name":", Hospital La Luz, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Sanz Rosa","sequence":"additional","affiliation":[{"name":", Universidad Europea, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Cou\u00f1ago Lorenzo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Hospital Universitario Quir\u00f3nsalud Madrid, , Spain"},{"name":", Hospital La Luz, , Spain"},{"name":", Universidad Europea, , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/BD-201022_ref1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"10.3233\/BD-201022_ref2","unstructured":"Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, et al. 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