{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:05:20Z","timestamp":1777467920167,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"s1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2021,6,25]]},"abstract":"<jats:p>BACKGROUND: With essential metals being studied and developed as anticancer agents, this study aims to explore the anticancer activity of Zn(II) arginine dithiocarbamate in the T47D and fibroblast cell lines. METHOD: The Zn(II) arginine dithiocarbamate complex was prepared by the in situ method and characterized using infra-red spectroscopy, melting point, X-ray fluorescence, and X-ray diffraction instruments. The complex compound was tested for its cytotoxicity to the T47D breast cancer and fibroblast cell lines. RESULTS: The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to the T47D breast cancer cell line obtained IC50 = 3.16\u00a0\u03bcg\/mL, while cisplatin obtained IC50 = 28.18\u00a0\u03bcg\/mL. The cytotoxicity of the Zn(II) arginine dithiocarbamate complex to fibroblast cells obtained IC50 = 8709.63\u00a0\u03bcg\/mL. CONCLUSION: The Zn(II) arginine dithiocarbamate complex has increased active cytotoxicity compared to cisplatin in inducing morphological changes in the T47D breast cancer cell line and is relatively non-toxic to fibroblast cells.<\/jats:p>","DOI":"10.3233\/bd-219008","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T13:19:27Z","timestamp":1622207967000},"page":"S55-S61","source":"Crossref","is-referenced-by-count":6,"title":["The comparison of Zn(II) arginine dithiocarbamate cytotoxicity in T47D breast cancer and fibroblast cells"],"prefix":"10.1177","volume":"40","author":[{"given":"Prihantono","family":"Prihantono","sequence":"first","affiliation":[{"name":", , Hasanuddin University, , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rizal","family":"Irfandi","sequence":"additional","affiliation":[{"name":"Department of Biology Education, Faculty of Teacher Training and Education, Universitas Puangrimaggalatung, , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indah","family":"Raya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Mathematics, and Natural Science, Hasanuddin University, , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/BD-219008_ref1","volume-title":"Logam Berat Sekitar Manusia","author":"Adhani"},{"issue":"1","key":"10.3233\/BD-219008_ref2","first-page":"D112","article-title":"Analisis pemakaian kemoterapi pada kasus kanker payudara dengan menggunakan metode regresi logistik multinomial (studi kasus pasien di rumah sakit \u201cx\u201d surabaya)","volume":"1","author":"Yudissanta","year":"2012","journal-title":"J Sains dan seni its"},{"issue":"1","key":"10.3233\/BD-219008_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7819-6-112","article-title":"Correlation of HER-2 over-expression with clinico-pathological parameters in Tunisian breast carcinoma","volume":"6","author":"Ayadi","year":"2008","journal-title":"World J Surg Oncol"},{"issue":"12","key":"10.3233\/BD-219008_ref4","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.dnarep.2006.07.007","article-title":"Genetic analysis of ionizing radiation-induced mutagenesis in Saccharomyces cerevisiae reveals TransLesion Synthesis (TLS) independent of PCNA K164 SUMOylation and ubiquitination","volume":"5","author":"Chen","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"10.3233\/BD-219008_ref5","unstructured":"Prevention C for DC and National diabetes statistics report, 2017."},{"issue":"17","key":"10.3233\/BD-219008_ref6","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.1021\/om060394o","article-title":"In vitro evaluation of rhodium and osmium RAPTA analogues: The case for organometallic anticancer drugs not based on ruthenium","volume":"25","author":"Dorcier","year":"2006","journal-title":"Organometallics"},{"key":"10.3233\/BD-219008_ref7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ica.2015.11.011","article-title":"Study of metal dithiocarbamate complexes, Part V. Metal complexes of [S2CN (CH2CH (OMe) 2]: A standard dimeric zinc dithiocarbamate structural motive, a rare cadmium dithiocarbamate coordination polymer, and a hydrated sodium dithiocarbarmate complex, with a [Na2O2] core and chain","volume":"441","author":"Ferreira","year":"2016","journal-title":"Inorganica Chim Acta"},{"issue":"7","key":"10.3233\/BD-219008_ref8","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.bcp.2005.01.001","article-title":"Anticancer metal compounds in NCI\u2019s tumor-screening database: Putative mode of action","volume":"69","author":"Huang","year":"2005","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.3233\/BD-219008_ref9","first-page":"45","article-title":"Kompleks praseodimium ditiokarbamat 1, 10 fenantrolin","volume":"39","author":"Baba","year":"2010","journal-title":"Sains Malaysiana"},{"issue":"1","key":"10.3233\/BD-219008_ref10","first-page":"93","article-title":"New mixed ligands complexes of samarium (III) with dithiocarbamates and 1, 10-phenanthroline","volume":"10","author":"Raya","year":"2006","journal-title":"Malaysia J Anal Sci"},{"issue":"3","key":"10.3233\/BD-219008_ref11","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1381-5148(98)00083-2","article-title":"Spectrophotometric determination of copper complexation properties of new amphiphilic dithiocarbamates","volume":"42","author":"Rogachev","year":"1999","journal-title":"React Funct Polym"},{"issue":"3","key":"10.3233\/BD-219008_ref12","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bmc.2005.09.006","article-title":"99mTc-labeling of colchicine using [99mTc(CO)3(H2O)3]+ and [99mTcN]2+ core for the preparation of potential tumor-targeting agents","volume":"14","author":"Korde","year":"2006","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"10.3233\/BD-219008_ref14","first-page":"1","article-title":"Anti-cancer effects of zinc (II) ion in tumor formation and growth, proliferation, metastasis and DNA damage","volume":"1","author":"Ishida","year":"2017","journal-title":"Degener Intellect Dev Disabil"},{"issue":"2","key":"10.3233\/BD-219008_ref15","first-page":"251","article-title":"Sintesis dan Pencirian Sebatian Sek-Butilpropil-Ditiokarbamat daripada Logam Zink (II), Kadmium (II) dan Stibium (III)","volume":"10","author":"Awang","year":"2006","journal-title":"Malaysian J Anal Sci"},{"issue":"7\u20138","key":"10.3233\/BD-219008_ref16","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.fitote.2008.06.007","article-title":"Weerapreeyakul N Cytotoxic activity screening of some indigenous Thai plants","volume":"79","author":"Prayong","year":"2008","journal-title":"Fitoterapia"},{"key":"10.3233\/BD-219008_ref17","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.amsu.2020.11.018","article-title":"Potential anticancer activity of Mn (II) complexes containing arginine dithiocarbamate ligand on MCF-7 breast cancer cell lines","volume":"60","author":"Irfandi","year":"2020","journal-title":"Ann Med Surg"}],"container-title":["Breast Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BD-219008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:32:13Z","timestamp":1777383133000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BD-219008"}},"subtitle":[],"editor":[{"given":"Andi Nilawati","family":"Usman","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":16,"journal-issue":{"issue":"s1"},"URL":"https:\/\/doi.org\/10.3233\/bd-219008","relation":{},"ISSN":["0888-6008","1558-1551"],"issn-type":[{"value":"0888-6008","type":"print"},{"value":"1558-1551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]}}}