{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:06:23Z","timestamp":1777467983606,"version":"3.51.4"},"reference-count":71,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:p>BACKGROUND AND AIM: DCIS is the most common type of non-invasive breast cancer, accounting for about 15 to 30%. Proteome profile is used to detect biomarkers in the tissues of breast cancer patients by mass spectrometry. This study aimed to obtain the expression profile of DCIS proteome, and the expression profile of invasive biomarkers, and finally to introduce a dedicated biomarker panel to facilitate the prognosis and early detection for in situ breast cancer patients. METHODS AND MATERIALS: In this study, 10 patients with breast cancer (DCIS) were studied. Benign (marginal) and cancerous tissue samples were obtained from patients for proteomics experiments. Initially, all tissue proteins were extracted using standard methods, and the proteins were separated using two-dimensional electrophoresis. Then, the expression amount of the extracted proteins was determined by ITRAQ. The data were analysed by R software, and gene ontology was utilised for describing the protein in detail. RESULTS: 30 spots on gel electrophoresis were found in the tumor tissue group (sample), and 15 spots in the margin group (control) with P &lt;\u00a00.05. Healthy and cancerous tissue gels showed that 5 spots had different expression. VWF, MMP9, ITGAM, MPO and PLG protein spots were identified using the site www.ebi.ac.uk\/IPI. Finally, protein biomarkers for breast tumor tissue with margin were introduced with the names of P04406, P49915, P05323, P06733, and P02768. DISCUSSION: There are 5 critical proteins in inducing cancer pathways especially complement and coagulation cascades. The hall markers of a healthy cell to be cancerous are proliferation, invasion, angiogenesis, and changes in the immune system. Hence, regulation of protein plays a key role in developing recurrence to breast cancer in margins.<\/jats:p>","DOI":"10.3233\/bd-220017","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T12:04:58Z","timestamp":1673611498000},"page":"513-520","source":"Crossref","is-referenced-by-count":4,"title":["Proteome profiling of ductal carcinoma in situ"],"prefix":"10.1177","volume":"41","author":[{"given":"Zeinb","family":"Mosavi","sequence":"first","affiliation":[{"name":", Islamic Azad University, , , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haniyeh","family":"Bashi Zadeh Fakhar","sequence":"additional","affiliation":[{"name":"Cancer Research Centre (CRC), Shahid Beheshti University of Medical Sciences, , Iran"},{"name":", Islamic Azad University, , , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa","family":"Rezaei-Tavirani","sequence":"additional","affiliation":[{"name":"Proteomics Research Center, Shahid Beheshti University of Medical Sciences, , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamd Esmaeel","family":"Akbari","sequence":"additional","affiliation":[{"name":"Cancer Research Centre (CRC), Shahid Beheshti University of Medical Sciences, , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Forouzan","family":"Rostami","sequence":"additional","affiliation":[{"name":", Islamic Azad University, , Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/BD-220017_ref1","first-page":"251","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"25","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"issue":"2","key":"10.3233\/BD-220017_ref2","first-page":"275","article-title":"Out come of breast cancer in Iran: a study of Tehran cancer Registry data","volume":"9","author":"Mousavi","year":"2008","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"10.3233\/BD-220017_ref3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40169-018-0192-7","article-title":"Extracellular vesicles as circulating cancer biomarkers: opportunities and challenges","volume":"7","author":"Lane","year":"2018","journal-title":"Clin Transl Med"},{"key":"10.3233\/BD-220017_ref4","unstructured":"WHO, Classification of breast tumours, in: WHO Classification of Tumours Editorial Board. 5th ed., Geneva, Switzerland, 102\u2013112, 2, 2019."},{"key":"10.3233\/BD-220017_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000313481808400102","article-title":"Controversies regarding the diagnosis and management of ductal carcinoma in situ","volume":"84","author":"Levinsohn","year":"2018","journal-title":"Am Surg"},{"key":"10.3233\/BD-220017_ref6","first-page":"1066","article-title":"Differences in pathologic characteristics between ductal carcinoma in situ (DCIS), DCIS with microinvasion and DCIS with invasive ductal carcinoma","volume":"13","author":"Liu","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"key":"10.3233\/BD-220017_ref7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.molonc.2010.06.007","article-title":"Molecular diversity in ductal carcinoma in situ (DCIS) and early invasive breast cancer","volume":"4","author":"Muggerud","year":"2010","journal-title":"Mol Oncol"},{"key":"10.3233\/BD-220017_ref8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.canrad.2016.04.004","article-title":"Breast conserving treatment for ductal carcinoma in situ: impact of boost and tamoxifen on local recurrences","volume":"20","author":"Cutuli","year":"2016","journal-title":"Cancer Radiother"},{"issue":"10","key":"10.3233\/BD-220017_ref9","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/annonc\/mdz189","article-title":"Early breast cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"30","author":"Cardoso","year":"2019","journal-title":"Ann Oncol"},{"key":"10.3233\/BD-220017_ref10","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ejca.2018.07.003","article-title":"Breast cancer-related deaths according to grade in ductal carcinoma in situ: a dutch population-based study on patients diagnosed between 1999 and 2012","volume":"101","author":"Van Maaren","year":"2018","journal-title":"Eur J Cancer"},{"key":"10.3233\/BD-220017_ref11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13048-019-0535-z","article-title":"Proteome profiling of low grade serous ovarian cancer","volume":"12","author":"Fakhar","year":"2019","journal-title":"J Ovarian Res"},{"key":"10.3233\/BD-220017_ref12","doi-asserted-by":"crossref","first-page":"e4995","DOI":"10.1002\/bmc.4995","article-title":"The separation sciences, the front end to proteomics: an historical perspective","volume":"35","author":"Nice","year":"2021","journal-title":"Biomed Chromatogr"},{"key":"10.3233\/BD-220017_ref13","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1021\/acs.analchem.8b04894","article-title":"Recent advances in multidimensional separation for proteome analysis","volume":"91","author":"Yuan","year":"2019","journal-title":"Anal Chem"},{"key":"10.3233\/BD-220017_ref14","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/acs.jproteome.0c00670","article-title":"Extending the depth of human plasma proteome coverage using simple fractionation techniques","volume":"20","author":"Kaur","year":"2021","journal-title":"J Proteome Res"},{"issue":"11","key":"10.3233\/BD-220017_ref15","doi-asserted-by":"crossref","first-page":"e2197","DOI":"10.17795\/zjrms-2197","article-title":"Studying the proteomic pattern of cancerous tissue in patients with breast cancer and its\u2019 comparing with healthy breast","volume":"17","author":"Behboodi","year":"2015","journal-title":"Zahedan J Res Med Sci"},{"issue":"69","key":"10.3233\/BD-220017_ref16","first-page":"137","article-title":"Biomarkers of basal cell carcinoma using proteomic analysis","volume":"3","author":"Morvaj","year":"2009","journal-title":"J Pajohandeh"},{"key":"10.3233\/BD-220017_ref17","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"10.3233\/BD-220017_ref18","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.7717\/peerj.2775","article-title":"Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis","volume":"4","author":"Safari-Alighiarloo","year":"2016","journal-title":"PeerJ"},{"key":"10.3233\/BD-220017_ref19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer statistics","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.3233\/BD-220017_ref20","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.3390\/ijms19113333","article-title":"Chemotherapy-exacerbated breast cancer metastasis: A paradox explainable by dysregulated adaptive-response","volume":"19","author":"Middleton","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.3233\/BD-220017_ref21","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0300-483X(93)90066-2","article-title":"Myeloperoxidasemediated activation of xenobiotics by human leukocytes","volume":"82","author":"Hofstra","year":"1993","journal-title":"Toxicology"},{"key":"10.3233\/BD-220017_ref22","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1038\/s41467-020-19045-9","article-title":"A high-stringency blueprint of the human proteome","volume":"11","author":"Adhikari","year":"2020","journal-title":"Nat Commun"},{"key":"10.3233\/BD-220017_ref23","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0165-9936(03)00508-9","article-title":"Proteome analysis by two-dimensional gel electrophoresis and mass spectrometry: strengths and limitation","volume":"22","author":"Beranova-Giorgianni","year":"2003","journal-title":"Trend Anal Chem"},{"key":"10.3233\/BD-220017_ref24","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.jchromb.2010.01.013","article-title":"Targeted quantitative analysis of superoxide dismutase 1 in cisplatin-sensitive and cisplatin-resistant human ovariancancer cells","volume":"878","author":"Kim","year":"2010","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"33","key":"10.3233\/BD-220017_ref25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/ng1106","article-title":"Proteomics: the first decade and beyond","volume":"2","author":"Patterson","year":"2003","journal-title":"Nat Genet"},{"issue":"1","key":"10.3233\/BD-220017_ref26","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1586\/14789450.1.1.67","article-title":"Integrated analysis of genetic, genomic and proteomic data","volume":"1","author":"Reif","year":"2004","journal-title":"Expert Rev Proteomics"},{"key":"10.3233\/BD-220017_ref27","doi-asserted-by":"crossref","first-page":"4886","DOI":"10.1002\/pmic.200800298","article-title":"Difference gel electrophoresis","volume":"8","author":"Timms","year":"2008","journal-title":"J Proteomics"},{"issue":"2","key":"10.3233\/BD-220017_ref28","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1021\/pr5009948","article-title":"Metabolomic serumprofiling detects early-stage high-grade serous ovarian cancer in a mouse model","volume":"14","author":"Jones","year":"2015","journal-title":"J Proteome Res"},{"key":"10.3233\/BD-220017_ref29","doi-asserted-by":"crossref","first-page":"4735","DOI":"10.1021\/acs.jproteome.0c00485","article-title":"Research on the human proteome reaches a major milestone: >90% of predicted human proteins now credibly detected, according to the hupo human proteome project","volume":"19","author":"Omenn","year":"2020","journal-title":"J Proteome Res"},{"key":"10.3233\/BD-220017_ref30","doi-asserted-by":"crossref","first-page":"277","DOI":"10.3322\/caac.20073","article-title":"Cancer statistics","volume":"60","author":"Jemal","year":"2010","journal-title":"CA Cancer J Clin"},{"key":"10.3233\/BD-220017_ref31","doi-asserted-by":"crossref","first-page":"e0227404","DOI":"10.1371\/journal.pone.0227404","article-title":"Comparative proteomic analysis of different stages of breast cancer tissues using ultra high performance liquid chromatography tandem mass spectrometer","volume":"15","author":"Al-Wajeeh","year":"2020","journal-title":"PLoS One"},{"key":"10.3233\/BD-220017_ref32","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1021\/acs.jproteome.0c00670","article-title":"Extending the depth of human plasma proteome coverage using simple fractionation techniques","volume":"20","author":"Kaur","year":"2021","journal-title":"J Proteome Res"},{"key":"10.3233\/BD-220017_ref33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/omi.2009.0008","article-title":"Quantitative proteomics analysis integrated with microarray data reveals that extracellular matrix proteins, catenins, and p53 binding protein 1 are important for chemotherapy response in ovarian cancers","volume":"13","author":"Pan","year":"2009","journal-title":"OMICS"},{"issue":"3","key":"10.3233\/BD-220017_ref34","doi-asserted-by":"crossref","first-page":"147","DOI":"10.21873\/cgp.20120","article-title":"Increased RNA expression of von Willebrand factor gene is associated with infiltrating lobular breast cancer and normal PAM50 subtype","volume":"16","author":"Lehrer","year":"2019","journal-title":"Cancer Genom Proteom"},{"issue":"2","key":"10.3233\/BD-220017_ref35","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1055\/s-0037-1607352","article-title":"Emerging roles for von Willebrand factor in cancer cell biology","volume":"44","author":"O\u2019Sullivan","year":"2018","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"10.3233\/BD-220017_ref36","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0049-3848(96)00149-1","article-title":"von Willebrand factor antigen in blood plasma of patients with urinary bladder carcinoma","volume":"83","author":"Zietek","year":"1996","journal-title":"Thromb Res"},{"issue":"3","key":"10.3233\/BD-220017_ref37","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/gyno.1994.1146","article-title":"Pretreatment plasma levels of fibrinopeptide-A (FPA), d-dimer (DD), and von Willebrand factor (vWF) in patients with ovarian carcinoma","volume":"53","author":"Gadducci","year":"1994","journal-title":"Gynecol Oncol"},{"issue":"10","key":"10.3233\/BD-220017_ref38","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/pros.21319","article-title":"Endothelial progenitor cells and circulating endothelial cells in early prostate cancer: a comparison with plasma vascular markers","volume":"71","author":"Blann","year":"2011","journal-title":"Prostate"},{"key":"10.3233\/BD-220017_ref39","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1590\/S0100-879X2001000900004","article-title":"Von Willebrand factor antigen levels in plasma of patients with malignant breast disease","volume":"34","author":"R\u00f6hsig","year":"2011","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"10.3233\/BD-220017_ref40","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3233\/CBM-191096","article-title":"Pre-surgical level of von Willebrand factor as an evident indicator of breast cancer recurrence","volume":"29","author":"Rhone","year":"2020","journal-title":"Cancer Biomark"},{"issue":"1","key":"10.3233\/BD-220017_ref41","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41389-017-0023-5","article-title":"Cancer cell-derived von Willebrand factor enhanced metastasis of gastric adenocarcinoma","volume":"7","author":"Yang","year":"2018","journal-title":"Oncogenesis"},{"issue":"1","key":"10.3233\/BD-220017_ref42","first-page":"350","article-title":"Tumor-type-dependent effects on the angiogenic abilities of endothelial cells in an in vitro rat cell model","volume":"42","author":"Al-Abboodi","year":"2019","journal-title":"Oncol Rep"},{"issue":"20","key":"10.3233\/BD-220017_ref43","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1182\/blood-2014-08-595686","article-title":"von Willebrand factor fibers promote cancer-associated plateletaggregation in malignant melanoma of mice and humans","volume":"125","author":"Bauer","year":"2015","journal-title":"Blood"},{"key":"10.3233\/BD-220017_ref44","first-page":"126","article-title":"The role of van willbrand factor in breast cancer metastasis","volume":"5","author":"Yin Goh","year":"2021","journal-title":"Transl Oncol"},{"key":"10.3233\/BD-220017_ref45","doi-asserted-by":"crossref","first-page":"14091","DOI":"10.1038\/s41598-018-32433-y","article-title":"A novel mechanism of plasminogen activation in epithelial and mesenchymal cells","volume":"8","author":"Bydoun","year":"2018","journal-title":"Sci Rep"},{"key":"10.3233\/BD-220017_ref46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/mutage\/11.1.3","article-title":"The role of peroxidase-catalyzed activation of aromatic amines in breast cancer","volume":"11","author":"Josephy","year":"1996","journal-title":"Mutagenesis"},{"key":"10.3233\/BD-220017_ref47","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0300-483X(93)90066-2","article-title":"Myeloperoxidasemediated activation of xenobiotics by human leukocytes","volume":"82","author":"Hofstra","year":"1993","journal-title":"Toxicology"},{"key":"10.3233\/BD-220017_ref48","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe","volume":"77","author":"Klebanoff","year":"2005","journal-title":"J Leukoc Biol"},{"key":"10.3233\/BD-220017_ref49","doi-asserted-by":"crossref","first-page":"5436","DOI":"10.1158\/1078-0432.CCR-07-0481","article-title":"Myeloperoxidase is a key regulator of oxidative stress mediated apoptosis in myeloid leukemic cells","volume":"13","author":"Nakazato","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.3233\/BD-220017_ref50","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.ccr.2004.05.016","article-title":"Tamoxifen resistance by a conformational arrest of the estrogen receptor alpha after PKA activation in breast cancer","volume":"5","author":"Michalides","year":"2004","journal-title":"Cancer Cell"},{"key":"10.3233\/BD-220017_ref51","doi-asserted-by":"crossref","first-page":"8300","DOI":"10.1074\/jbc.M311625200","article-title":"Peroxisome proliferator-activated receptor gamma ligands regulate myeloperoxidase expression in macrophages by an estrogen-dependent mechanism involving the 463GA promoter polymorphism","volume":"279","author":"Kumar","year":"2004","journal-title":"J Biol Chem"},{"key":"10.3233\/BD-220017_ref52","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/00062752-200001000-00010","article-title":"Myeloperoxidase","volume":"7","author":"Winterbourn","year":"2000","journal-title":"Curr Opin Hematol"},{"key":"10.3233\/BD-220017_ref53","doi-asserted-by":"crossref","first-page":"14412","DOI":"10.1074\/jbc.271.24.14412","article-title":"An Alu element in the myeloperoxidase promoter contains a composite SP1-thyroid hormone-retinoic acid response element","volume":"271","author":"Piedrafita","year":"1996","journal-title":"J Biol Chem"},{"issue":"3","key":"10.3233\/BD-220017_ref54","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s10549-019-05336-3","article-title":"In filtration by myeloperoxdase positive neutrophils is an independent prognostic factor in breast cancer","volume":"177","author":"Zeindler","year":"2019","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.3233\/BD-220017_ref55","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3892\/ijo.2017.3883","article-title":"Inflammatory peroxidase promote breast cancer progression in mice via regulation of the tumor microenviroment","volume":"50","author":"Panagopoulos","year":"2017","journal-title":"Int J Oncol"},{"key":"10.3233\/BD-220017_ref56","first-page":"115","article-title":"Breast cancer cell invasion mediated by Ga 12 signaling involves expression of interleukins -6 and -8 and matrix metalloproteinase - 2","volume":"26","author":"Chia","year":"2009","journal-title":"J Mol Signal"},{"issue":"3","key":"10.3233\/BD-220017_ref57","first-page":"3370","article-title":"Angiopietin -1 inhibits vascular tumors","volume":"12","author":"Stoeltzing","year":"2003","journal-title":"Cancer Res"},{"key":"10.3233\/BD-220017_ref58","first-page":"451","article-title":"Transient RNA silencing of tissue factor pathway inhibitor - 2 modulates lung cancer cell invasion","volume":"26","author":"Lochmann","year":"2009","journal-title":"Clin EXP Metastasis"},{"issue":"11","key":"10.3233\/BD-220017_ref59","first-page":"881","article-title":"Research on tge correlation of MMP 9 and p 53 expression with the prognosis of triple negative breast cancer","volume":"2","author":"Huang","year":"2014","journal-title":"xiandai shengwu Yixue jinzhan"},{"key":"10.3233\/BD-220017_ref60","doi-asserted-by":"crossref","first-page":"143952","DOI":"10.1016\/j.gene.2019.143952","article-title":"Breast cancer invasion and progression by MMP-9 through Ets-1 transcription factor","volume":"711","author":"Nazir","year":"2019","journal-title":"Gene"},{"issue":"1","key":"10.3233\/BD-220017_ref61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-018-1076-x","article-title":"CD 68, CD163 and matrux metalloproteinase 9 (MMP,9) colocalization in breast tumir microenvironment preducts survival differently in ER-positive and -begative cancer","volume":"20","author":"Pelekanou","year":"2018","journal-title":"Breast Cancer Res"},{"issue":"5","key":"10.3233\/BD-220017_ref62","first-page":"5865","article-title":"The relationship between MMP-2 and MMP.9 expression levels with breast cancer incidence and prognosis","volume":"14","author":"Hai","year":"2017","journal-title":"Oncology"},{"key":"10.3233\/BD-220017_ref63","first-page":"654","volume-title":"Phlegmasia alba dolens: Clinique medicale de l\u2019HotelDieu de Paris","author":"Akna","year":"1865"},{"key":"10.3233\/BD-220017_ref64","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1042\/bst0300201","article-title":"Coagulation proteases and human cancer","volume":"30","author":"Kakkar","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"10.3233\/BD-220017_ref65","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1158\/1078-0432.113.11.1","article-title":"Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer","volume":"11","author":"Wang","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.3233\/BD-220017_ref66","first-page":"3958","article-title":"Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer","volume":"63","author":"Yousef","year":"2003","journal-title":"Cancer Res"},{"issue":"3","key":"10.3233\/BD-220017_ref67","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11154-007-9037-1","article-title":"Stromal induction of breast cancer inflammation and invasion","volume":"8","author":"Radisky","year":"2007","journal-title":"Rev Endocr Metab Disord"},{"key":"10.3233\/BD-220017_ref68","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.3389\/fonc.2020.574552","article-title":"Isobaric tags for relative and absolute quantitation in proteomic analysis of potential biomarkers in invasive cancer, ductal carcinoma in situ, and mammary fibroadenoma","volume":"10","author":"Wu","year":"2020","journal-title":"Front Oncol"},{"issue":"8","key":"10.3233\/BD-220017_ref69","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1038\/s41416-020-0763-4","article-title":"Genetic heterogeneity and evolutionary history of high-grade ovarian carcinoma and matched distant metastases","volume":"122","author":"Masoodi","year":"2020","journal-title":"Br J Cancer"},{"issue":"9","key":"10.3233\/BD-220017_ref70","first-page":"124","article-title":"Evaluation of the effects of educational package on controlling the complications of chemotherapeutic agents on symptom scales of quality of life in patients with breast cancer undergoing chemotherapy","volume":"11","author":"Baghaei","year":"2013","journal-title":"Nursing and Midwifery Journal"},{"issue":"8","key":"10.3233\/BD-220017_ref71","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1080\/01635581.2019.1604005","article-title":"The relationship between anthropometric indices and breast cancer in central Iran","volume":"71","author":"Taleban","year":"2019","journal-title":"Nutr Cancer"}],"container-title":["Breast Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BD-220017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:32:27Z","timestamp":1777383147000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BD-220017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":71,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/bd-220017","relation":{},"ISSN":["0888-6008","1558-1551"],"issn-type":[{"value":"0888-6008","type":"print"},{"value":"1558-1551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,11]]}}}