{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:02:41Z","timestamp":1790730161043,"version":"4.1.0"},"reference-count":31,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2023,6,29]]},"abstract":"<jats:p>BACKGROUND: Lymphoma of the breast can be classified as either primary breast lymphoma (PBL) or secondary to systemic lymphoma (SBL). PBL is a rare disease with Diffuse Large B cell Lymphomas (DLBCL) being the most common subtype. OBJECTIVES: In the current study, we represented eleven cases diagnosed with breast lymphoma in our trust; two of them had PBL and nine had SBL. We focused mainly on the clinical presentation, diagnosis, management and outcomes. METHODS: We did this retrospective review for all breast lymphoma patients who were diagnosed in our trust during the periods from 2011\u20132022. Patients\u2019 data were obtained from the hospital recording system. We followed up these patients thus far to identify the outcome of treatment in each patient. RESULTS: Eleven patients were included in our review. All patients were females. Average age of diagnosis was 66.1 \u00b1 13 years of age. Eight patients were diagnosed with DLBCL, two patients were diagnosed with follicular lymphomas, and the last one had lymphoplasmacytic lymphoma. Chemotherapy +\u2215\u2212 radiotherapy was the standard treatment regimen in all patients. Four patients passed away within one year of chemotherapy, five patients achieved complete remission, one patient had two relapses and is still under treatment, while the last patient was diagnosed recently and still awaiting treatment. CONCLUSION: Primary breast lymphoma is an aggressive disease. The treatment for PBL is mainly systemic with chemoradiotherapy. The role of surgery is now limited to the diagnosis of the disease. Early diagnosis and proper treatment are crucial for the management of such cases.<\/jats:p>","DOI":"10.3233\/bd-220051","type":"journal-article","created":{"date-parts":[[2023,6,30]],"date-time":"2023-06-30T11:14:50Z","timestamp":1688123690000},"page":"197-205","source":"Crossref","is-referenced-by-count":7,"title":["Breast lymphoma: General review"],"prefix":"10.1177","volume":"42","author":[{"given":"Emad M.N.","family":"Rezkallah","sequence":"first","affiliation":[{"name":", James Cook University Hospital, , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Elsaify","sequence":"additional","affiliation":[{"name":"Misr University for Science and Technology, , Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su M.M.","family":"Tin","sequence":"additional","affiliation":[{"name":"South Tees Hospitals NHS Foundation Trust, , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debdeep","family":"Dey","sequence":"additional","affiliation":[{"name":"South Tees Hospitals NHS Foundation Trust, , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael M.","family":"Elsaify","sequence":"additional","affiliation":[{"name":", James Cook University Hospital, , United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/BD-220051_ref1","first-page":"311","article-title":"Primary non-Hodgkin\u2019s breast lymphoma: surgical approach","volume":"1","author":"Alessandro","year":"2008","journal-title":"Cases\u00a0J"},{"key":"10.3233\/BD-220051_ref2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1046\/j.1524-4741.2002.08509.x","article-title":"Lymphoma of the breast: clinical and radiologic features with pathologic correlation in 28 patients","volume":"8","author":"Sabate","year":"2002","journal-title":"Breast J"},{"key":"10.3233\/BD-220051_ref3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00000478-199403000-00009","article-title":"Non-Hodgkin\u2019s lymphoma involving the breast","volume":"18","author":"Arber","year":"1994","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.3233\/BD-220051_ref4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s13193-013-0269-0","article-title":"Primary breast diffuse large B cell lymphoma \u2013 report of 6 cases from South India with review of literature","volume":"4","author":"Lokesh","year":"2013","journal-title":"Indian J Surg Oncol"},{"key":"10.3233\/BD-220051_ref5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/10428190310001597892","article-title":"Primary malignant lymphoma of the breast: clinicopathological study of nine cases","volume":"45","author":"Park","year":"2004","journal-title":"Leukemia Lymphoma"},{"key":"10.3233\/BD-220051_ref6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/ajh.21353","article-title":"Primary breast non-Hodgkin\u2019s lymphoma: a large single center study of initial characteristics, natural history, and prognostic factors","volume":"84","author":"Validire","year":"2009","journal-title":"Am J Hematol"},{"key":"10.3233\/BD-220051_ref7","first-page":"381","article-title":"Primary breast lymphoma a breast mass as initial symptom","volume":"22","author":"Kim","year":"1999","journal-title":"Ann J Clin Oncol"},{"issue":"10","key":"10.3233\/BD-220051_ref8","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1002\/1097-0142(19921115)70:10<2451::AID-CNCR2820701011>3.0.CO;2-B","article-title":"Primary non-Hodgkin lymphoma of the breast. 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