{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:15:57Z","timestamp":1791530157568,"version":"4.3.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2023,7,19]]},"abstract":"<jats:p>BACKGROUND: Metastases from extramammary malignant neoplasms are very rare, accounting for less than 2% of all breast malignancies. OBJECTIVE: The aim of this study is to describe the clinicopathological features and prognosis of breast metastases from non-primary breast malignancies at our institution. METHODS: We performed a retrospective observational study, obtaining data from electronic medical records and pathology databases between January 1985 and December 2020 for patients diagnosed with breast metastasis from non-primary breast malignancies. Only patients diagnosed by biopsy were included. RESULTS: Fifteen patients diagnosed with breast metastases from non-primary breast malignancies were included, 13 women (86,67%) and 2 men (13,33%). The median age at time of initial diagnosis was 56 years (IQR 21\u201368). The most frequent primary malignancy was melanoma (9\/15; 60%). The median time to diagnosis of breast metastases was 65 months (IQR 13\u2013106). The most common diagnostic modality was CT-scan (10\/15; 66,67%). The median follow-up was 96 months (IQR 29\u2013136). Eight patients underwent surgery (53,3%), being the most common surgical intervention breast-conserving surgery (5\/8; 62,5%). Mortality at the end of follow-up was 53,3% (8\/15). On the survival analysis, we found no differences between patients undergoing surgery and those only receiving systemic treatment [41,5 months (IQR 17,5\u201357,5) versus 14 months (IQR 2\u201324), respectively; p = 0,161]. CONCLUSIONS: Breast metastases from non-primary breast malignancies are extremely rare and represent a diagnostic and therapeutic challenge, due to the poor prognosis of these patients. Thus, arriving at the correct diagnosis is crucial to avoid unnecessary treatment in this population.<\/jats:p>","DOI":"10.3233\/bd-220056","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T11:04:54Z","timestamp":1689937494000},"page":"223-228","source":"Crossref","is-referenced-by-count":4,"title":["Breast metastases from non-primary breast malignancies: What should we know?"],"prefix":"10.1177","volume":"42","author":[{"given":"\u00c1ngela","family":"Santana Valenciano","sequence":"first","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz Divina","family":"Juez S\u00e1ez","sequence":"additional","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"P\u00e9rez Mies","sequence":"additional","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Corral","family":"Moreno","sequence":"additional","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Rivas","family":"Fidalgo","sequence":"additional","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobo Caba\u00f1as","family":"Montero","sequence":"additional","affiliation":[{"name":", University Hospital Ram\u00f3n y Cajal, , Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/BD-220056_ref1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12957-016-0915-4","article-title":"Non-primary breast malignancies: A single institution\u2019s experience of a diagnostic challenge with important therapeutic consequences-a retrospective 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