{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:07:27Z","timestamp":1777468047401,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:p>BACKGROUND: Neuro-Behcet\u2019s disease (NBD) is a variant of Behcet\u2019s disease (BD). To our knowledge, there have been no previous reports on concurrent NBD in breast cancer patients undergoing chemotherapy. CASE PRESENTATION: Our patient had a history of BD and was asymptomatic. She was diagnosed with human epidermal growth factor receptor 2-positive breast cancer by core needle biopsy and was administered neoadjuvant chemotherapy. After four courses, in addition to the aggravation of the existing adverse events, headache, fever, dysarthria, and muscle weakness in the upper left and lower extremities appeared. On admission, she was diagnosed with acute NBD, and steroid therapy was initiated. After her symptoms improved gradually, she was discharged. Then, she underwent mastectomy and axillary lymph node dissection for breast cancer. Trastuzumab and pertuzumab plus tamoxifen were administered postoperatively. Two years postoperatively, no recurrence of breast cancer and NBD was noted. CONCLUSION: When chemotherapy is administered to breast cancer patients with a history of BD, it is necessary to select chemotherapy with as few adverse events as possible and to continue with treatment while paying attention to the risk of NBD.<\/jats:p>","DOI":"10.3233\/bd-230026","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:43:47Z","timestamp":1720179827000},"page":"223-229","source":"Crossref","is-referenced-by-count":1,"title":["Development of neuro-Behcet\u2019s disease in a patient with operable HER2-positive breast cancer during neoadjuvant chemotherapy: A case report"],"prefix":"10.1177","volume":"43","author":[{"given":"Taketo","family":"Nakai","sequence":"first","affiliation":[{"name":", Keio University School of Medicine, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohito","family":"Seki","sequence":"additional","affiliation":[{"name":", Kyorin University School of Medicine, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akitsugu","family":"Makino","sequence":"additional","affiliation":[{"name":", Saitama Medical Center, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshie","family":"Kadota","sequence":"additional","affiliation":[{"name":", Saitama Medical Center, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Kaburagi","sequence":"additional","affiliation":[{"name":", Saitama Medical Center, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Okumura","sequence":"additional","affiliation":[{"name":", Saitama Medical Center, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Karahashi","sequence":"additional","affiliation":[{"name":", Saitama Medical Center, , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/BD-230026_ref1","doi-asserted-by":"publisher","first-page":"987393","DOI":"10.3389\/fmed.2022.987393","article-title":"Mucocutaneous manifestations of Beh\u00e7et\u2019s disease: Pathogenesis and management from perspectives of vasculitis","volume":"9","author":"Kim","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.3233\/BD-230026_ref2","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1093\/brain\/122.11.2171","article-title":"Clinical patterns of neurological involvement in Beh\u00e7et\u2019s disease: Evaluation of 200 patients","volume":"122","author":"Akman-Demir","year":"1999","journal-title":"Brain"},{"key":"10.3233\/BD-230026_ref3","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1136\/jnnp.64.3.382","article-title":"Beh\u00e7et\u2019s syndrome: A report of 41 patients with emphasis on neurological manifestations","volume":"64","author":"Farah","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/BD-230026_ref4","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1056\/nejmoa1609214","article-title":"Fulminant myocarditis with combination immune checkpoint blockade","volume":"375","author":"Johnson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.3233\/BD-230026_ref5","volume-title":"in: Regular and Young Investigator Award Abstracts","author":"Illarramendi","year":"2023"},{"key":"10.3233\/BD-230026_ref6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jns.2015.01.005","article-title":"Retrospective analysis of long-term outcome of chronic progressive neurological manifestations in Behcet\u2019s disease","volume":"349","author":"Hirohata","year":"2015","journal-title":"J Neurol Sci"},{"key":"10.3233\/BD-230026_ref7","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3109\/s10165-011-0533-5","article-title":"Clinical characteristics of neuro-Behcet\u2019s disease in Japan: A multicenter retrospective analysis","volume":"22","author":"Hirohata","year":"2012","journal-title":"Mod Rheumatol"},{"key":"10.3233\/BD-230026_ref8","doi-asserted-by":"publisher","first-page":"391","DOI":"10.12659\/AJCR.889560","article-title":"Paraneoplastic limbic encephalitis, an uncommon presentation of a common cancer: Case report and discussion","volume":"14","author":"Said","year":"2013","journal-title":"Am J Case Rep"},{"key":"10.3233\/BD-230026_ref9","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1136\/jnnp.2003.034447","article-title":"Recommended diagnostic criteria for paraneoplastic neurological syndromes","volume":"75","author":"Graus","year":"2004","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/BD-230026_ref10","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1093\/brain\/123.7.1481","article-title":"Paraneoplastic limbic encephalitis: Neurological symptoms, immunological findings and tumour association in 50 patients","volume":"123 (Pt7)","author":"Gultekin","year":"2000","journal-title":"Brain"},{"key":"10.3233\/BD-230026_ref11","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/s40164-016-0058-x","article-title":"Paraneoplastic neurological complications of breast cancer","volume":"5","author":"Fanous","year":"2015","journal-title":"Exp Hematol Oncol"},{"key":"10.3233\/BD-230026_ref12","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1007\/s00415-013-7209-3","article-title":"Diagnosis and management of Neuro-Beh\u00e7et\u2019s disease: International consensus recommendations","volume":"261","author":"Kalra","year":"2014","journal-title":"J Neurol"},{"key":"10.3233\/BD-230026_ref13","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3109\/14397595.2014.891496","article-title":"Analysis of various factors on the relapse of acute neurological attacks in Beh\u00e7et\u2019s disease","volume":"24","author":"Hirohata","year":"2014","journal-title":"Mod Rheumatol"},{"key":"10.3233\/BD-230026_ref14","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fnhum.2017.00316","article-title":"Inflammation: The common pathway of stress-related diseases","volume":"11","author":"Liu","year":"2017","journal-title":"Front Hum Neurosci"},{"key":"10.3233\/BD-230026_ref15","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000216188","article-title":"Enhancing versus suppressive effects of stress on immune function: Implications for immunoprotection and immunopathology","volume":"16","author":"Dhabhar","year":"2009","journal-title":"Neuroimmunomodulation"},{"key":"10.3233\/BD-230026_ref16","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: The good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol Res"},{"key":"10.3233\/BD-230026_ref17","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.genhosppsych.2006.10.001","article-title":"Quality of life in patients with Beh\u00e7et\u2019s disease: The impact of major depression","volume":"29","author":"Ug\u0306uz","year":"2007","journal-title":"Gen Hosp Psychiatry"},{"key":"10.3233\/BD-230026_ref18","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S1470-2045(11)70336-9","article-title":"Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (NeoSphere): A randomised multicentre, open-label, phase 2 trial","volume":"13","author":"Gianni","year":"2012","journal-title":"Lancet Oncol"},{"key":"10.3233\/BD-230026_ref19","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1056\/NEJMoa1703643","article-title":"APHINITY Steering Committee and Investigators, Adjuvant pertuzumab and trastuzumab in early HER2-positive breast cancer","volume":"377","author":"von Minckwitz","year":"2017","journal-title":"N Engl J Med"},{"key":"10.3233\/BD-230026_ref20","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1056\/NEJMoa1814017","article-title":"KATHERINE Investigators, Trastuzumab emtansine for residual invasive HER2-positive breast cancer","volume":"380","author":"von Minckwitz","year":"2019","journal-title":"N Engl J Med"}],"container-title":["Breast Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BD-230026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:32:40Z","timestamp":1777383160000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BD-230026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":20,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/bd-230026","relation":{},"ISSN":["0888-6008","1558-1551"],"issn-type":[{"value":"0888-6008","type":"print"},{"value":"1558-1551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]}}}