{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:07:11Z","timestamp":1777468031506,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2023,10,18]]},"abstract":"<jats:p>BACKGROUND: Fibroadenomas are the most common benign breast lesions in women. They present as a unilateral mass and can rapidly enlarge in size through hormonal changes. Fibroadenomas could be classified as small or giant, and as simple or complex. They are classified as \u2018giant\u2019 when the size exceeds 5 cm and\/or weight 500 gram; and as \u2018complex\u2019 if one of the following characteristics is present: cysts with a size &gt;3 mm, epithelial calcifications, sclerosing adenosis and papillary apocrine metaplasia. Giant fibroadenomas can cause compression of surrounding breast tissue or breast asymmetry, requiring surgical excision in order to preserve a normal breast shape. CASE: A 26-year-old pregnant woman was referred with a palpable mass of her right breast. The mass rapidly increased in size to a diameter of 13\u00a0cm during the second trimester of her pregnancy. A tru-cut biopsy confirmed a fibroadenoma. The rapid growth and compression of normal breast tissues indicated a lumpectomy during her pregnancy. The mass was easily excised without any consequences for the pregnancy. Pathological examination showed a complex giant fibroadenoma. CONCLUSION: A unique case of a pregnant woman with rapid progression of a fibroadenoma that met the criteria of a complex and giant fibroadenoma, was presented. This case emphasizes the importance of timely surgical intervention, even during pregnancy, to prevent permanent breast tissue damage.<\/jats:p>","DOI":"10.3233\/bd-230030","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:35:57Z","timestamp":1698147357000},"page":"325-330","source":"Crossref","is-referenced-by-count":1,"title":["A rapidly growing fibroadenoma in a pregnant woman: A case report"],"prefix":"10.1177","volume":"42","author":[{"given":"I.M.","family":"Brouwer de Koning","sequence":"first","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.C.","family":"van Heusden","sequence":"additional","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.J.J.","family":"Mol","sequence":"additional","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.L.","family":"Rots","sequence":"additional","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.A.","family":"Draaisma","sequence":"additional","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Bosscha","sequence":"additional","affiliation":[{"name":", Jeroen Bosch Hospital, , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/BD-230030_ref1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s13691-017-0299-5","article-title":"Giant fibroadenoma with massive infarction masquerading as malignancy: a case report","volume":"6","author":"Singh","year":"2017","journal-title":"Int Cancer Conf J"},{"key":"10.3233\/BD-230030_ref2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clinimag.2020.10.058","article-title":"Fibroadenomas: a multidisciplinary review of the variants","volume":"71","author":"Basara Akin","year":"2021","journal-title":"Clin Imaging"},{"issue":"1","key":"10.3233\/BD-230030_ref3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3233\/BD-2009-0288","article-title":"Giant fibroadenoma in a 22 year old patient: Case report and literature review","volume":"31","author":"McCague","year":"2010","journal-title":"Breast Dis"},{"key":"10.3233\/BD-230030_ref4","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1046\/j.1525-1497.1998.cr188.x","article-title":"Management of breast fibroadenomas","volume":"13","author":"Greenberg","year":"1998","journal-title":"J Gen Intern Med"},{"key":"10.3233\/BD-230030_ref5","doi-asserted-by":"crossref","unstructured":"Nigam JS, Tewari P, Prasad T, Kumar T, Kumar A, Carcinoma breast-like giant complex fibroadenoma: a clinical masquerade, Cureus, 2021.","DOI":"10.7759\/cureus.12611"},{"key":"10.3233\/BD-230030_ref6","doi-asserted-by":"crossref","unstructured":"Jena S, Sinha NK, Use of lateral oncoplasty for multiquadrant giant fibroadenoma: a novel approach, Cureus, 13(5)2021. [cited 2022 Apr 21]. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/34155459\/.","DOI":"10.7759\/cureus.15090"},{"issue":"5","key":"10.3233\/BD-230030_ref7","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/GCO.0b013e32832fa06b","article-title":"Fibroadenomas in adolescence","volume":"21","author":"Jayasinghe","year":"2009","journal-title":"Curr Opin Obstet Gynecol"},{"issue":"1","key":"10.3233\/BD-230030_ref8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00404-011-1923-9","article-title":"Diagnosis and management of an unilateral giant fibroadenoma of the breast in pregnancy","volume":"285","author":"Heilmann","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.3233\/BD-230030_ref9","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2214\/AJR.07.2330","article-title":"Incidence and management of complex fibroadenomas","volume":"190","author":"Sklair-Levy","year":"2008","journal-title":"Am J Roentgenol"},{"key":"10.3233\/BD-230030_ref10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ijscr.2019.09.015","article-title":"Giant fibroadenoma of the breast: A rare case in a mature woman","volume":"63","author":"Meng","year":"2019","journal-title":"Int J Surg Case Rep"},{"key":"10.3233\/BD-230030_ref11","doi-asserted-by":"publisher","first-page":"105202","DOI":"10.1016\/j.ijscr.2020.10.096","article-title":"A harmless evil: Giant fungating benign breast mass in an adolescent mimicking malignancy \u2013 Case report","volume":"80","author":"Heng","year":"2021","journal-title":"Int J Surg Case Rep"},{"issue":"5","key":"10.3233\/BD-230030_ref12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.3109\/2000656X.2012.697066","article-title":"Differential diagnosis and management of giant fibroadenoma: comparing excision with reduction mammoplasty incision and excision with inframammary incision","volume":"46","author":"Ugburo","year":"2012","journal-title":"J Plast Surg Hand Surg"},{"issue":"3","key":"10.3233\/BD-230030_ref13","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1056\/NEJMra035692","article-title":"Benign breast disorders","volume":"353","author":"Santen","year":"2005","journal-title":"N Engl J Med"},{"issue":"5","key":"10.3233\/BD-230030_ref14","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1309\/F523-FMJV-W886-3J38","article-title":"Histopathology of fibroadenoma of the breast","volume":"115","author":"Kuijper","year":"2001","journal-title":"Am J Clin Pathol"},{"issue":"2","key":"10.3233\/BD-230030_ref15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.amjsurg.2006.04.007","article-title":"Phyllodes tumors of the breast: A case series of 106 patients","volume":"192","author":"Ben hassouna","year":"2006","journal-title":"Am J Surg"},{"issue":"3","key":"10.3233\/BD-230030_ref16","doi-asserted-by":"crossref","first-page":"324","DOI":"10.6004\/jnccn.2007.0027","article-title":"Phyllodes tumors of the breast: natural history, diagnosis, and treatment historical overview","volume":"5","author":"Carlson","year":"2007","journal-title":"J Natl Compr Cancer Netw"},{"key":"10.3233\/BD-230030_ref17","doi-asserted-by":"crossref","first-page":"152069","DOI":"10.1016\/j.anndiagpath.2022.152069","article-title":"\u2018Growing fibroadenoma\u2019: Are there clinical and pathological features predicting a phyllodes tumor on surgical excision?","volume":"62","author":"Nam","year":"2023","journal-title":"Ann Diagn Pathol"},{"issue":"5","key":"10.3233\/BD-230030_ref18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1136\/jcp.2005.025866","article-title":"Optimising preoperative diagnosis in phyllodes tumour of the breast","volume":"59","author":"Jacklin","year":"2006","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.3233\/BD-230030_ref19","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10549-015-3535-8","article-title":"Complex fibroadenoma and breast cancer risk: a Mayo Clinic Benign Breast Disease Cohort Study","volume":"153","author":"Nassar","year":"2015","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.3233\/BD-230030_ref20","first-page":"312","article-title":"Giant juvenile fibroadenoma: a systematic review with diagnostic and treatment recommendations","volume":"4","author":"Sosin","year":"2015","journal-title":"Gland Surg"},{"issue":"9","key":"10.3233\/BD-230030_ref21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.4236\/jct.2019.109059","article-title":"Unusual presentation of a rare giant fibroadenoma of the breast","volume":"10","author":"Darido","year":"2019","journal-title":"J Cancer Ther"},{"issue":"0","key":"10.3233\/BD-230030_ref22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.21037\/abs-20-107","article-title":"Review of the diagnosis and management of benign breast issues during pregnancy and lactation","volume":"5","author":"Poli","year":"2021","journal-title":"Ann Breast Surg"},{"issue":"3","key":"10.3233\/BD-230030_ref23","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4103\/TJOG.TJOG_51_17","article-title":"Giant fibroadenoma of the breast in late third trimester","volume":"34","author":"Moukit","year":"2023","journal-title":"Trop J Obstet Gynaecol"},{"issue":"7","key":"10.3233\/BD-230030_ref24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.28982\/josam.707606","article-title":"sunumu O. Giant fibroadenoma of the breast: A case report of a 37-year-old woman during the second trimester of pregnancy. Memenin dev fibroadenomu: Gebeli\u011fin ikinci trimesterinde olan 37 ya\u015f\u0131nda kad\u0131n olgu sunumu","volume":"4","author":"\u00c7itgez","year":"2020","journal-title":"J Surg Med"},{"issue":"8","key":"10.3233\/BD-230030_ref25","doi-asserted-by":"crossref","first-page":"9531","DOI":"10.5812\/ircmj.9531","article-title":"Giant fibroadenoma growing rapidly during pregnancy","volume":"16","author":"Karagulle","year":"2014","journal-title":"Iran Red Crescent Med J"},{"issue":"3","key":"10.3233\/BD-230030_ref26","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1515\/JPEM.2009.22.3.281","article-title":"Recurrence of giant juvenile breast fibroadenoma in a girl with Turner\u2019s syndrome","volume":"22","author":"Calcaterra","year":"2009","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"1","key":"10.3233\/BD-230030_ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3233\/BD-2010-0305","article-title":"Recurrent giant juvenile fibroadenomas with hemihypertrophy","volume":"33","author":"Tantrige","year":"2011","journal-title":"Breast Dis"},{"issue":"3","key":"10.3233\/BD-230030_ref28","doi-asserted-by":"publisher","first-page":"96","DOI":"10.2484\/rcr.v2i3.96","article-title":"Recurrent bilateral giant fibroadenomas of the breasts","volume":"2","author":"Morris","year":"2007","journal-title":"Radiol Case Rep"},{"issue":"3","key":"10.3233\/BD-230030_ref29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s12020-009-9176-0","article-title":"Progesterone receptors A and B and estrogen receptor alpha expression in normal breast tissue and fibroadenomas","volume":"35","author":"Branchini","year":"2009","journal-title":"Endocrine"}],"container-title":["Breast Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BD-230030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:32:37Z","timestamp":1777383157000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BD-230030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":29,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/bd-230030","relation":{},"ISSN":["0888-6008","1558-1551"],"issn-type":[{"value":"0888-6008","type":"print"},{"value":"1558-1551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,18]]}}}