{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T13:07:16Z","timestamp":1777468036603,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BD"],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:p>OBJECTIVE: To investigate the associations between breast cancer staging and body mass index (BMI), menopausal status, and family history of breast cancer, as well as to assess the expression of tumor markers in women with breast cancer in Brunei Darussalam. METHODS: A retrospective cross-sectional study was carried out at The Brunei Cancer Centre. Cases of women with breast cancer between 2000 and 2013 were retrieved from the medical records section and entered into a clinical proforma. These were reviewed and analyzed using appropriate statistical methods. RESULTS: Overall, the mean age at diagnosis was 53.6 years \u00b1 9.83. The postmenopausal women had a significantly higher risk of being diagnosed with late-onset breast cancer than premenopausal women (P =\u00a00.022). The expressions of PR (P =\u00a00.034), Her2 (P =\u00a00.046), and CatD (P =\u00a00.004) were significantly different in breast cancer staging. Other factors did not have a statistically-significant association with breast cancer staging. CONCLUSION: While most of the factors studied were not significantly different in breast cancer staging, our findings showed that it is recommended that high-risk women perform regular breast screening after the age of 40 years old. A future study highly appreciates comparing breast cancer risk factors among the Bruneian and Western populations.<\/jats:p>","DOI":"10.3233\/bd-239001","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T11:06:10Z","timestamp":1687259170000},"page":"183-189","source":"Crossref","is-referenced-by-count":1,"title":["Study of risk factors and marker status in women with breast cancer in Brunei Darussalam"],"prefix":"10.1177","volume":"42","author":[{"given":"Chieng Bing","family":"Wong","sequence":"first","affiliation":[{"name":"Pengiran Anak Puteri Rashidah Sa\u2019adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, , , Brunei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aklimah","family":"Mustapa","sequence":"additional","affiliation":[{"name":"Pengiran Anak Puteri Rashidah Sa\u2019adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, , , Brunei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siti Nur Idayu","family":"Matusin","sequence":"additional","affiliation":[{"name":"Pengiran Anak Puteri Rashidah Sa\u2019adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, , , Brunei"},{"name":"Halalan Thayyiban Research Centre, Universiti Islam Sultan Sharif Ali, , Brunei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Syafiq","family":"Abdullah","sequence":"additional","affiliation":[{"name":"Raja Isteri Pengiran Anak Saleha Hospital, , , Brunei"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andi Nilawati","family":"Usman","sequence":"additional","affiliation":[{"name":"Graduate School, Hasanuddin University, , Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mas Rina Wati","family":"Haji Abdul Hamid","sequence":"additional","affiliation":[{"name":"Pengiran Anak Puteri Rashidah Sa\u2019adatul Bolkiah (PAPRSB) Institute of Health Sciences, Universiti Brunei Darussalam, , , Brunei"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/BD-239001_ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/CAAC.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.3233\/BD-239001_ref2","unstructured":"Ministry of Health, Health Information Booklet 2017. 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