{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T22:51:15Z","timestamp":1779317475897,"version":"3.51.4"},"reference-count":32,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T00:00:00Z","timestamp":1643068800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder Cancer"],"published-print":{"date-parts":[[2022,4,24]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>MRI has been proposed as a new staging tool for bladder cancer (BC), but use is limited by its high costs and low availability. 29-MHz high-resolution micro-ultrasound (mUS) technology has been suggested as an alternative to detect BC and distinguish between muscle-invasive and non-muscle invasive BC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>The aim was to compare the diagnostic accuracy of mUS vs. magnetic resonance imaging (MRI) in differentiating NMIBC and MIBC at definitive pathological examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>This is a prospective study of patients with a primary diagnosis of BC with either positive urine cytology (UC) or negative UC and a tumor size &gt;\u200a25\u200amm from a tertiary care high volume center. mUS, with the ExactVu system with an EV29L 29\u200aMHz side-fire transducer, and a 3-Tesla MRI were performed before transurethral resection of bladder tumor (TURBT) in every patient before undergoing TURBT. We compared the imaging results with pathological reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>The analyzed population consisted of 58 individuals. The reported mUS and MRI sensitivity, specificity, positive, and negative predictive values were 85.0%, 76.3%, 65.4%, and 90.6%, versus 85.0%, 50.0%, 47.2%, and 86.4%, respectively. In accuracy analysis, the AUC for mUS and MRI were respectively 0.807 and 0.675.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>In our population mUS seems to have a better performance in distinguishing NMIBC from MIBC. The main limitation of mUS is the probe shape that makes its use problematic in cases with a large prostate and inadequate rectal preparation. Further studies with a larger population are ongoing to compare and validate these techniques in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/blc-211611","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T13:41:40Z","timestamp":1643118100000},"page":"119-127","source":"Crossref","is-referenced-by-count":13,"title":["Head-to-Head Comparison between High-Resolution Microultrasound Imaging and Multiparametric MRI in Detecting and Local Staging of Bladder Cancer: The BUS-MISS Protocol"],"prefix":"10.1177","volume":"8","author":[{"given":"Pietro","family":"Diana","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Lughezzani","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Saita","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Uleri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Frego","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Contieri","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolomaria","family":"Buffi","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Balzarini","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federico","family":"D\u2019Orazio","sequence":"additional","affiliation":[{"name":"Department of Radiology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colombo","family":"Piergiuseppe","sequence":"additional","affiliation":[{"name":"Department of Pathology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Grazia","family":"Elefante","sequence":"additional","affiliation":[{"name":"Department of Pathology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Lazzeri","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Guazzoni","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Humanitas University, Milan, Italy"},{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Casale","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo","family":"Hurle","sequence":"additional","affiliation":[{"name":"Department of Urology, IRCCS Humanitas Research Hospital, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,1,25]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2017.03.030"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14673"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14465"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2016.06.004"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4759-2"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14366"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.06.029"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.04.029"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2020.02.007"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12110446"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2018.10.001"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2020.09.013"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-019-02863-y"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.03.044"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.21037\/tau.2019.08.20"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.03.018"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.5430\/jst.v6n2p56"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.01.004"},{"key":"ref019","author":"Moch 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