{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:54:00Z","timestamp":1777463640962,"version":"3.51.4"},"reference-count":37,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder Cancer"],"published-print":{"date-parts":[[2022,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Mucosal melanoma involving the urethra is a rare disease with distinct clinical and molecular characteristics and poor outcomes. Our current knowledge is limited by the small number of reports regarding this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To describe the clinical, pathological, and molecular characteristics of urethral melanoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We summarized the clinicopathologic data for 31 patients treated for urethral melanoma from 1986\u20132017 at our institution. Genomic data from our institutional sequencing platform MSK-IMPACT ( n\u200a=\u200a5) and gene-specific PCR data on BRAF, KIT, and\/or NRAS ( n\u200a=\u200a8) were compared to genomic data of cutaneous melanomas ( n\u200a=\u200a143), vulvar\/vaginal melanomas ( n\u200a=\u200a24), and primary non-melanoma urethral tumors ( n\u200a=\u200a5) from our institutional database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Twenty-three patients were diagnosed with localized disease, 7 had regional\/nodal involvement and one had metastases. Initial treatment included surgery in 25 patients; seven had multimodal treatment. Median follow-up was 46 months (IQR 33\u2013123). Estimated 5-year cancer-specific survival was 45%. No significant change in survival was observed based on a year of treatment. Primary urethral melanomas showed a higher frequency of TP53 mutations compared to cutaneous (80.0% vs. 18.2%, p\u200a=\u200a0.006) and vulvar\/vaginal melanomas (80.0 vs. 25.0%, p\u200a=\u200a0.04). BRAF mutations were absent in urethral primaries (0% vs. 46% in cutaneous melanoma, p\u200a=\u200a0.02). Tumor mutation burden was higher in cutaneous than urethral melanomas ( p\u200a=\u200a0.04). Urethral melanomas had a higher number of somatic alterations compared to non-melanoma urethral tumors (median 11 vs. 5, p\u200a=\u200a0.03).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Our findings support a unique mutational landscape of urethral melanoma compared to cutaneous melanoma. Survival remains poor and is unchanged over the time studied.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/blc-211633","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T11:39:52Z","timestamp":1656070792000},"page":"291-301","source":"Crossref","is-referenced-by-count":7,"title":["Urethral Melanoma \u2013 Clinical, Pathological and Molecular Characteristics"],"prefix":"10.1177","volume":"8","author":[{"given":"Roy","family":"Mano","sequence":"first","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Urology, Tel-Aviv Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Tel Aviv-Yafo, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Hoeh","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Urology, University Hospital Frankfurt, Goethe University Frankfurt am Main, Frankfurt am Main, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renzo G.","family":"DiNatale","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Department of Urology and Renal Transplantation, Virginia Mason Medical Center, Seattle, WA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"},{"name":"Division of Urology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole E.","family":"Benfante","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Reznik","sequence":"additional","affiliation":[{"name":"Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario M.","family":"Leitao","sequence":"additional","affiliation":[{"name":"Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander N.","family":"Shoushtari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvin","family":"Goh","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Machele","family":"Donat","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry W.","family":"Herr","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard H.","family":"Bochner","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Dalbagni","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy F.","family":"Donahue","sequence":"additional","affiliation":[{"name":"Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"ref001","first-page":"1664","volume":"83","author":"Chang AE","year":"1998","journal-title":"The American College of Surgeons Commission on Cancer and the American Cancer Society. 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