{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:55:15Z","timestamp":1777463715289,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T00:00:00Z","timestamp":1686614400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bladder Cancer"],"published-print":{"date-parts":[[2023,6,19]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Devices that increase the penetrance of intravesical chemotherapeutics are emerging as alternatives to classical Bacillus Calmette Gu\u00e9rin (BCG) treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>To compare the efficacy of mitomycin C applied with the electromotive drug delivery device (MMC-EMDA) versus BCG in patients with intermediate and high-risk non-muscle-invasive bladder cancer (NMIBC) without carcinoma in situ (CIS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>Prospective non-randomized study in which 47 patients received MMC-EMDA (40\u200amg of MMC diluted in 50\u200amg of distilled water at 20\u200amA for 30\u200amin. Regimen of 6 weekly and then 6 monthly instillations) and 48 patients received BCG (50\u200amg of OncoCITE\u00ae diluted in 50\u200aml of normal saline for 60\u200amin. Regimen of 6 weekly instillations and then 3 weekly instillations at months 3, 6 and 12). The primary endpoint was the recurrence-free rate (RFR) at 24 months. Secondary endpoints were time to recurrence and progression-free rate (PFR) at 24 months follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Baseline patient assessment and mean follow-up time were similar in both groups (MMC-EMDA group: 26.4 months; BCG group: 28.4 months ( p\u200a=\u200a0.44)). The RFR at 24 months was 80.9% for the MMC-EMDA group and 77.1% for the BCG group ( p\u200a=\u200a0.969). The mean time to recurrence was 12.5 months in the MMC-EMDA group and 14 months in the BCG group ( p\u200a=\u200a0.681). At 24 months, PFR was 97.9% in the MMC-EMDA group and 93.8% in the BCG group ( p\u200a=\u200a0.419).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>No differences were found between MMC-EMDA and BCG treatments in patients with high-risk and intermediate-risk NMIBC without CIS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/blc-230042","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T10:50:45Z","timestamp":1686912645000},"page":"159-166","source":"Crossref","is-referenced-by-count":1,"title":["Electromotive Drug Administration Chemotherapy with Mitomycin C Versus Bacillus Calmette-Guerin for the Treatment of Non-Muscle Invasive Bladder Cancer"],"prefix":"10.1177","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4183-2060","authenticated-orcid":false,"given":"Mar\u00eda Teresa","family":"Melgarejo Segura","sequence":"first","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Morales Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaiza","family":"Y\u00e1\u00f1ez Castillo","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9774-8485","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Arrabal Polo","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria ibs. GRANADA, Complejo Hospitales Universitarios de Granada\/Universidad de Granada, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Guti\u00e9rrez Tejero","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Pareja V\u00edlchez","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6661-1811","authenticated-orcid":false,"given":"Miguel","family":"Arrabal Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Urology, University Hospital SanCecilio, Granada, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2023,6,13]]},"reference":[{"key":"ref001","unstructured":"EAU-Guidelines-on-Non-Muscle-Invasive-Bladder-Cancer-2022.pdf [Internet]. [cited 2022 Jul 28]. Available from: https:\/\/d56bochluxqnz.cloudfront.net\/documents\/full-guideline\/EAU-Guidelines-on-Non-Muscle-Invasive-Bladder-Cancer-2022.pdf"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.045"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2013.07.021"},{"issue":"19","key":"ref004","first-page":"5144","volume":"51","author":"Dalton JT","year":"1991","journal-title":"Cancer Res"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/s41585-018-0092-z"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1159\/000052419"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70190-5"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5134-7"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.2309"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000080568.91703.18"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70472-1"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1159\/000520630"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.01.006"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-03928-1"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2020.11.002"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.09.005"}],"container-title":["Bladder Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BLC-230042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/BLC-230042","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BLC-230042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:21:19Z","timestamp":1777382479000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/BLC-230042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,13]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6,19]]}},"alternative-id":["10.3233\/BLC-230042"],"URL":"https:\/\/doi.org\/10.3233\/blc-230042","relation":{},"ISSN":["2352-3727","2352-3735"],"issn-type":[{"value":"2352-3727","type":"print"},{"value":"2352-3735","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,13]]}}}