{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:12:32Z","timestamp":1777464752700,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>Triterpenes have shown many beneficial activities in researches, but their separation and preparation usually require multiple methods. Following an initial cleaning-up step on the AB-8 macroporous resin, a preparative high-speed counter-current chromatography (HSCCC) with a two-phase solvent system comprising chloroform-n-butyl alcohol-methanol-water (10:1:7:4, v\/v\/v\/v) was used to isolate and separate triterpenes from caculis of Schisandra Chinensis (Turcz.) baill. A total of 89 mg corosolic acid with purities of 98.5% were obtained from 400 mg crude extract in one-step elution and less than 4 h, and the structure identification was performed by UV, IR, MS, 1H NMR and 13C NMR. The inhibition on liver fibrosis activities of the triterpenes against HSC-T6 in vitro were studied by cell culture methods. The results showed that the corosolic acid have better inhibitory effects on HSC-T6 cells with the IC50 value of 5\u223c25 \u03bcg\/mL and the study also indicated that corosolic acid might be a potential Chinese medical component to inhibit liver fibrosis.<\/jats:p>","DOI":"10.3233\/bme-130892","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T14:41:41Z","timestamp":1575297701000},"page":"969-977","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of High-Speed Counter-Current Chromatography for Isolation of Triterpenes from Schisandra Chinensis (Turcz.) Baill and Induction Apoptosis Mechanism of HSC-T6"],"prefix":"10.1177","volume":"24","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"College of Food Science Shenyang Agricultural University Dongling Road 120 Shenhe District, Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjun","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Food Science Shenyang Agricultural University Dongling Road 120 Shenhe District, Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Food Science Shenyang Agricultural University Dongling Road 120 Shenhe District, Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyao","family":"Jiao","sequence":"additional","affiliation":[{"name":"College of Food Science Shenyang Agricultural University Dongling Road 120 Shenhe District, Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachen","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Food Science Shenyang Agricultural University Dongling Road 120 Shenhe District, Shenyang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1]]},"container-title":["Bio-Medical Materials and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-130892","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-130892","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:24:01Z","timestamp":1777382641000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/BME-130892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.3233\/BME-130892"],"URL":"https:\/\/doi.org\/10.3233\/bme-130892","relation":{},"ISSN":["0959-2989","1878-3619"],"issn-type":[{"value":"0959-2989","type":"print"},{"value":"1878-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}