{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:17:31Z","timestamp":1777465051147,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>The purpose of this study was to assess gender-related distinction in the performance of Cushing's disease (CD) regarding clinical features, radiological findings, neurological and endocrine status, surgical outcome, and quality of life in Han Chinese. A retrospective study was conducted on 87 patients treated by trans-sphenoidal surgery, between 2006 and 2011, at a single treatment center in Shandong Provincial Hospital, China. Features of CD were compared and quality of life was analyzed between genders. The female-to-male ratio was 2.78: 1. Results showed that men have a younger age of diagnosis (P&lt;0.001), a larger adenoma diameter (P&lt;0.001), and a higher invasion rate (P=0.032) and apoplexy rate (P=0.04) than women. To be specific, compared with women, men are more prone to suffering from osteoporosis, hypokalemia, sexual dysfunction, and hypertension (P&lt;0.05), have significantly higher preoperative and postoperative (six months after surgery) cortisol levels (P&lt;0.001, P=0.003) and a higher recurrence rate (30.43% vs. 7.81%; P=0.028). No significant differences were seen in the CushingQoL scores between genders. Therefore, male patients with CD need more careful and long-term follow-up than female patients.<\/jats:p>","DOI":"10.3233\/bme-141168","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T14:58:43Z","timestamp":1575298723000},"page":"3439-3446","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Gender differences in presentation and outcome of patients with Cushing's disease in Han Chinese"],"prefix":"10.1177","volume":"24","author":[{"given":"Cheng","family":"Huan","sequence":"first","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan 250021, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanming","family":"Qu","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong University, Ji'nan 250021, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongming","family":"Ren","sequence":"additional","affiliation":[{"name":"College of Life Science, Shandong Normal University, Ji'nan 250014, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,11]]},"container-title":["Bio-Medical Materials and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-141168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-141168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:24:47Z","timestamp":1777382687000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/BME-141168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.3233\/BME-141168"],"URL":"https:\/\/doi.org\/10.3233\/bme-141168","relation":{"is-cited-by":[{"id-type":"doi","id":"10.3389\/fendo.2017.00222","asserted-by":"object"}]},"ISSN":["0959-2989","1878-3619"],"issn-type":[{"value":"0959-2989","type":"print"},{"value":"1878-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11]]}}}