{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:22:37Z","timestamp":1791426157398,"version":"4.3.3"},"reference-count":0,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:p>Designing unique nanostructured biomimetic materials is a new challenge in modern regenerative medicine. In order to develop functional substitutes for damaged organs or tissues, several methods have been used to create implants able to regenerate robust and durable bone. Electrospinning produces nonwoven scaffolds based on polymer nanofibers mimicking the fibrillar organization of bone extracellular matrix. Here, we describe a biomimetic 3D thick nanofibrous scaffold obtained by electrospinning of the biodegradable, bioresorbable and FDA-approved polymer, poly(\u03b5-caprolactone). Such scaffold presents a thickness reaching one centimeter. We report here the demonstration that the designed nanostructured implant is able to induce in vivo bone regeneration.<\/jats:p>","DOI":"10.3233\/bme-141248","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T15:04:10Z","timestamp":1575299050000},"page":"79-85","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Nanostructured thick 3D nanofibrous scaffold can induce bone"],"prefix":"10.1177","volume":"25","author":[{"given":"Sandy","family":"Eap","sequence":"first","affiliation":[{"name":"French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Facult\u00e9 de M\u00e9decine, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Morand","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Facult\u00e9 de M\u00e9decine, Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de Chirurgie Dentaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Clauss","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Facult\u00e9 de M\u00e9decine, Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de Chirurgie Dentaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Huck","sequence":"additional","affiliation":[{"name":"French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Facult\u00e9 de M\u00e9decine, Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, 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(INSERM), Osteoarticular and Dental Regenerative Nanomedicine, UMR 1109, Facult\u00e9 de M\u00e9decine, Strasbourg, France"},{"name":"Universit\u00e9 de Strasbourg, Facult\u00e9 de Chirurgie Dentaire, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,2]]},"container-title":["Bio-Medical Materials and 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