{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:26:15Z","timestamp":1777465575994,"version":"3.51.4"},"reference-count":31,"publisher":"SAGE Publications","issue":"1_suppl","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:p>\n                    Liver transplantation is the definitive treatment for patients with end-stage liver diseases (ESLD). However, it is hampered by shortage of liver donor. Liver tissue engineering, aiming at fabricating new livers\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , provides a potential resolution for donor shortage. Three elements need to be considered in liver tissue engineering: seeding cell resources, scaffolds and bioreactors. Studies have shown potential cell sources as hepatocytes, hepatic cell line, mesenchymal stem cells and others. They need scaffolds with perfect biocompatiblity, suitable micro-structure and appropriate degradation rate, which are essential charateristics for cell attachment, proliferation and secretion in forming extracellular matrix. The most promising scaffolds in research include decellularized whole liver, collagens and biocompatible plastic. The development and function of cells in scaffold need a microenvironment which can provide them with oxygen, nutrition, growth factors, et al. Bioreactor is expected to fulfill these requirements by mimicking the living condition\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    . Although there is great progress in these three domains, a large gap stays still between their researches and applications. Herein, we summarized the recent development in these three major fields which are indispensable in liver tissue engineering.\n                  <\/jats:p>","DOI":"10.3233\/bme-171632","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T18:12:36Z","timestamp":1490983956000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Research progress in liver tissue engineering"],"prefix":"10.1177","volume":"28","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"First Hospital of Kun Ming (Affiliated Calmette Hospital of Kunming Medical University)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Guan","sequence":"additional","affiliation":[{"name":"First Hospital of Kun Ming (Affiliated Calmette Hospital of Kunming Medical University)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Song","family":"Ye","sequence":"additional","affiliation":[{"name":"First Hospital of Kun Ming (Affiliated Calmette Hospital of Kunming Medical University)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Feng","family":"Yin","sequence":"additional","affiliation":[{"name":"First Hospital of Kun Ming (Affiliated Calmette Hospital of Kunming Medical University)","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Stoltz","sequence":"additional","affiliation":[{"name":"Lorraine University","place":["France"]},{"name":"CHRU Nancy","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"de Isla","sequence":"additional","affiliation":[{"name":"Lorraine University","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,1]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"271","article-title":"In vitro modeling of alcohol-induced liver injury using human-induced pluripotent stem cells","author":"Tian L.","year":"2016","unstructured":"TianL.PrasadN. and JangY.Y., In vitro modeling of alcohol-induced liver injury using human-induced pluripotent stem cells, Methods Mol Biol (2016), 271\u2013283.","journal-title":"Methods Mol Biol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","unstructured":"GuanJ.et al. 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