{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:14:57Z","timestamp":1777464897078,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"3-4","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bio-Medical Materials and Engineering"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>\n                    Aim: Assessing the activity of synovitis, which is characterized by an increase in cell metabolism, is important for the prediction of future articular destruction in clinical and preclinical studies. To evaluate the correlation between\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation and arthritis pathology during its establishment, we used microPET to evaluted\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation in vivo during rat Mycobacterium wall-induced knee arthritis.\n                  <\/jats:p>\n                  <jats:p>\n                    Methods:\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET images of arthritic rats were acquired on days 1, 2, 3 and 7 after arthritis induction. The subjects (n=2\/time) were subsequently subjected to macro-autoradiography, and\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation was compared with histological findings.\n                  <\/jats:p>\n                  <jats:p>\n                    Results:\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG PET images depicted swollen joints, and\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation increased with the progression of arthritis. Histologically, increased\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation correlated with the pannus rather than the infiltration of inflammatory cells around the joints.\n                  <\/jats:p>\n                  <jats:p>\n                    Conclusion:\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG accumulation in arthritis reflects proliferating pannus and inflammatory activity enhanced by inflammatory cytokines.\n                    <jats:sup>18<\/jats:sup>\n                    F-FDG microPET should be effective for quantifying the inflammatory activity of arthritis and\/or its therapeutic response.\n                  <\/jats:p>","DOI":"10.3233\/bme-2010-0632","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T14:12:57Z","timestamp":1575295977000},"page":"195-202","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a rat knee mono-arthritis using microPET"],"prefix":"10.1177","volume":"20","author":[{"given":"Joseph","family":"Paquet","sequence":"first","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fathia","family":"Maskali","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, H\u00f4pitaux de Brabois, Centre Hospitalo-Universitaire de Nancy-Brabois, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sylvain","family":"Poussier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, H\u00f4pitaux de Brabois, Centre Hospitalo-Universitaire de Nancy-Brabois, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Scala Bertola","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid","family":"Pinzano","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Grossin","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Netter","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Olivier","sequence":"additional","affiliation":[{"name":"Service de M\u00e9decine Nucl\u00e9aire, H\u00f4pitaux de Brabois, Centre Hospitalo-Universitaire de Nancy-Brabois, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Gillet","sequence":"additional","affiliation":[{"name":"Service de Pharmacologie, Nancy Universit\u00e9, Physiopathologie, Pharmacologie et Ing\u00e9nierie Articulaires, Vandoeuvre-l\u00e8s-Nancy, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2010,5]]},"container-title":["Bio-Medical Materials and Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-2010-0632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/BME-2010-0632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:24:26Z","timestamp":1777382666000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/BME-2010-0632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["10.3233\/BME-2010-0632"],"URL":"https:\/\/doi.org\/10.3233\/bme-2010-0632","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1115\/1.4035647","asserted-by":"object"}]},"ISSN":["0959-2989","1878-3619"],"issn-type":[{"value":"0959-2989","type":"print"},{"value":"1878-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}