{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:13:49Z","timestamp":1777464829988,"version":"3.51.4"},"reference-count":56,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BME"],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:p>BACKGROUND: The effectiveness and availability of conservative therapies for osteonecrosis of the femoral head (ONFH) are limited. Transplantation of bone marrow mesenchymal stem cells (BMSCs) combined with Bio-Oss, which is a good bone scaffold biomaterial for cell proliferation and differentiation, is a new potential therapy. Of note, the expression of miRNAs was significantly modified in cells cultured with Bio-Oss, and MiR-214 was correlated positively with osteonecrosis. Furthermore, miR-214 was upregulated in cells exposed to Bio-Oss. OBJECTIVE: To investigate whether targeting miR-214 further improves the transplantation effect. METHODS: We treated BMSCs with agomiR-214 (a miR-214 agonist), antagomiR-214 (a miR-214 inhibitor), or vehicle, followed by their transplantation into ONFH model rats. RESULTS: Histological and histomorphometric data showed that bone formation was significantly increased in the experimental groups (Bio-Oss and BMSCs treated with antagomiR-214) compared with other groups. CONCLUSIONS: miR-214 participates in the inhibition of osteoblastic bone formation, and the inhibition of miR-214 to bone formation during transplantation therapy with Bio-Oss combined with BMSCs for ONFH.<\/jats:p>","DOI":"10.3233\/bme-211296","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T14:47:42Z","timestamp":1636123662000},"page":"351-364","source":"Crossref","is-referenced-by-count":2,"title":["Role of miR-214 in biomaterial transplantation therapy for osteonecrosis"],"prefix":"10.1177","volume":"33","author":[{"given":"Yuying","family":"Wang","sequence":"first","affiliation":[{"name":", , Hangzhou Normal University, , China"},{"name":", , Hangzhou Normal University, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"He","sequence":"additional","affiliation":[{"name":", , Hangzhou Normal University, , China"},{"name":", The\u00a0Affiliated Hospital of Hangzhou Normal University, , 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