{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T11:04:30Z","timestamp":1777633470204,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BME"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:p>BACKGROUND: The bulk metallic glass (BMG), Pd79Ag3.5P6Si9.5Ge2, has a high fracture toughness and has been found to accommodate post-yield stress, unlike most other BMG. Moreover, due to its greater noble gas composition it has a intrinsic corrosion resistance, ideal for dental and orthopedic implants. OBJECTIVE: This present study aimed to evaluate the in\u00a0vivo application of Pd79Ag3.5P6Si9.5Ge2 in a large translational sheep model to assess its efficacy to be utilized as an endosteal device. METHODS: Twelve implants in the form of cylindrical rods (3 mm in diameter) were produced through rapid quenching. Each sheep (n = 12) received one osteotomy in the mandibular region using rotary instrumentation, which was filled with Pd79Ag3.5P6Si9.5Ge2. After 6- and 24-weeks the animals were euthanized, and samples collected en bloc to conduct histomorphometric analysis. The degree of osseointegration were assessed through bone-to-implant contact (BIC). RESULTS: All samples revealed favorable BIC along with with fibrous connective tissue layers at both 6- and 24-weeks. Bone along with interfacial remodeling was observed in proximity with the metallic glass surface at 6 weeks with higher degrees of bone organization being observed at the later healing time, 24 weeks. CONCLUSIONS: The synthesized BMG, given its unique combination of toughness and strength, revealed potential to serve as an alternative to commonly used Ti alloys.<\/jats:p>","DOI":"10.3233\/bme-221392","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T11:55:33Z","timestamp":1666353333000},"page":"215-223","source":"Crossref","is-referenced-by-count":2,"title":["An in\u00a0vivo preclinical study assessing biocompatibility of Pd-based bulk metallic\u00a0glass"],"prefix":"10.1177","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-6527","authenticated-orcid":false,"given":"Lukasz","family":"Witek","sequence":"first","affiliation":[{"name":", , New York University College of Dentistry, , , USA"},{"name":", New York University Tandon School of Engineering, , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2739-0339","authenticated-orcid":false,"given":"Vasudev","family":"Vivekanand Nayak","sequence":"additional","affiliation":[{"name":", , New York University College of Dentistry, , , USA"},{"name":", New York University Tandon School of Engineering, , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5156-4154","authenticated-orcid":false,"given":"Ricardo","family":"Rodriguez Colon","sequence":"additional","affiliation":[{"name":"Icahn School of Medicine at Mount Sinai, , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6463-805X","authenticated-orcid":false,"given":"Andrea","family":"Torroni","sequence":"additional","affiliation":[{"name":", New York University School of Medicine, , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marios D.","family":"Demetriou","sequence":"additional","affiliation":[{"name":", California Institute of Technology, , , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo G.","family":"Coelho","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Miami Miller School of Medicine, , , USA"},{"name":"Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, , , United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/BME-221392_ref1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/ID.0b013e3182938d03","article-title":"Comparison of histological and three-dimensional characteristics of porous titanium granules and deproteinized bovine particulate grafts used for sinus floor augmentation in humans: A pilot study","volume":"22","author":"Vandeweghe","year":"2013","journal-title":"Implant Dent"},{"key":"10.3233\/BME-221392_ref2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.msec.2016.01.032","article-title":"Commercially pure titanium (cp-Ti) versus titanium alloy (Ti6Al4V) materials as bone anchored implants - Is one truly better than the other?","volume":"62","author":"Shah","year":"2016","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"10.3233\/BME-221392_ref3","doi-asserted-by":"crossref","first-page":"229","DOI":"10.25083\/rbl\/24.2\/229.235","article-title":"Immunohistochemical evaluation of autogenous mandibular bone grafts integration: An experimental study","volume":"24","author":"Nimigean","year":"2019","journal-title":"Rom Biotechnol Lett"},{"issue":"7","key":"10.3233\/BME-221392_ref4","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/jbm.a.34127","article-title":"Argon-based atmospheric pressure plasma enhances early bone response to rough titanium surfaces","volume":"100","author":"Coelho","year":"2012","journal-title":"J\u00a0Biomed Mater Res\u00a0A"},{"issue":"4","key":"10.3233\/BME-221392_ref5","first-page":"171","article-title":"Titanium corrosion: Implications for dental implants","volume":"24","author":"Shah","year":"2016","journal-title":"Eur J Prosthodont Restor Dent"},{"key":"10.3233\/BME-221392_ref6","doi-asserted-by":"crossref","unstructured":"J.C.M. 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