{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:14:23Z","timestamp":1777464863601,"version":"3.51.4"},"reference-count":39,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BME"],"published-print":{"date-parts":[[2023,3,10]]},"abstract":"<jats:p>BACKGROUND: The effect of casting parameters on the microstructure and corrosion resistance of Mg alloys is still limited, especially in clinical animal experiments. OBJECTIVE: We prepared a new magnesium rare earth alloy (Mg-Re, where Re is Ce or La) by vertical two-roll casting and Mg-A by further rolling. The microstructure characteristics, degradation behavior, and bone reaction of the two alloys were studied. METHOD: Ti, Mg-Re, and Mg-A alloy plates were implanted in a rat femur model, and their degradation behavior was observed 48 weeks later. RESULTS: In vivo experiments showed no significant changes around the femur in the Ti group, excluding external factors that may cause bone remodeling and lead to new bone formation. Mg-A induces more new bone formation than Mg-Re, which meets the necessary conditions to prevent pathological fracture. The specimen staining and sectioning showed that the liver and heart of rats implanted with magnesium alloys had no pathological changes and the cell structure was normal, similar to that of rats without a magnesium alloy. CONCLUSION: Mg-A alloy has good healing potential as a biodegradable implant material.<\/jats:p>","DOI":"10.3233\/bme-221415","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T13:23:31Z","timestamp":1660915411000},"page":"169-181","source":"Crossref","is-referenced-by-count":0,"title":["In vivo degradation and bone reaction of long-term fixation with a magnesium alloy made by twin-roll casting in a rat femur model"],"prefix":"10.1177","volume":"34","author":[{"given":"Ying","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Life Science and Green Chemistry, , , , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Information Systems, , , , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kumazawa","sequence":"additional","affiliation":[{"name":"Department of Life Science and Green Chemistry, , , , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongying","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Information Systems, , , , Japan"},{"name":", University of Science and Technology Liaoning, , China"},{"name":"Ningbo Haizhi Institute of Materials Industry Innovation, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"S2","key":"10.3233\/BME-221415_ref1","doi-asserted-by":"publisher","first-page":"S98","DOI":"10.2106\/00004623-200100022-00007","article-title":"Bone-graft substitutes: Facts, fictions, and applications","volume":"83","author":"Greenwald","year":"2001","journal-title":"J\u00a0Bone Joint Surg"},{"issue":"4","key":"10.3233\/BME-221415_ref2","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.biomaterials.2008.10.021","article-title":"In vitro corrosion and biocompatibility of binary magnesium alloys","volume":"30","author":"Gu","year":"2009","journal-title":"Biomaterials"},{"issue":"3","key":"10.3233\/BME-221415_ref3","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/S1003-6326(06)60094-0","article-title":"Hemolysis effect and calciumphosphate precipitation of heat- organic-film treated magnesium","volume":"16","author":"Gao","year":"2006","journal-title":"T Nonferr Metal Soc Chin"},{"issue":"1","key":"10.3233\/BME-221415_ref4","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.surfcoat.2004.01.004","article-title":"Evaluation of cyto-toxicity and corrosion behavior of alkali-heat-treated magnesium in simulated body fluid","volume":"185","author":"Li","year":"2004","journal-title":"Surf Coat Technol"},{"key":"10.3233\/BME-221415_ref5","doi-asserted-by":"publisher","first-page":"421","DOI":"10.4028\/www.scientific.net\/MSF.546-549.421","article-title":"Investigation on the potential of magnesium alloy AZ31 as a bone implant","volume":"546","author":"Duygulu","year":"2007","journal-title":"Mater Sci Forum"},{"issue":"1","key":"10.3233\/BME-221415_ref6","first-page":"41","article-title":"The resorbing metallic alloy \u201cOsteosinthezit\u201d as material for fastening broken bone","volume":"8","author":"Troitskii","year":"1944","journal-title":"Khirurgiia"},{"key":"10.3233\/BME-221415_ref8","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/j.msea.2016.04.093","article-title":"Rare earth texture and improved ductility in a Mg\u2013Zn\u2013Gd alloy after high-speed extrusion","volume":"667","author":"Jiang","year":"2016","journal-title":"Mater Sci Eng\u00a0A"},{"key":"10.3233\/BME-221415_ref9","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/j.actamat.2016.11.019","article-title":"Precipitation strengthening and reversed yield stress asymmetry in Mg alloys containing rare-earth elements: A quantitative study","volume":"124","author":"Hidalgo-Manrique","year":"2017","journal-title":"Acta Mater"},{"key":"10.3233\/BME-221415_ref10","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ijplas.2016.01.005","article-title":"Demonstration of alloying, thermal activation, and latent hardening effects on quasi-static and dynamic polycrystal plasticity of Mg alloy. 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