{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:14:28Z","timestamp":1777464868134,"version":"3.51.4"},"reference-count":34,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BME"],"published-print":{"date-parts":[[2023,5,16]]},"abstract":"<jats:p>BACKGROUND: Pulmonary artery stenosis is a serious threat to people\u2019s life and health. OBJECTIVE: The hydrodynamic mechanism of pulmonary artery stenosis is investigated. METHODS: Numerical analysis of hemodynamics in pulmonary artery stenosis using computational fluid dynamics techniques is performed. An idealized model of pulmonary artery stenosis is established, and the model is divided into main pulmonary artery, right and left pulmonary arteries, and their branches. The sections at different positions are intercepted to study the distribution trend of maximum velocity, pressure and wall shear stress. RESULTS: The numerical simulation results show that the pressure drop at both ends of the narrow area is large. High velocity and wall shear stress exist in the center of stenosis, and the wall shear stress at the distal end of stenosis gradually decreases, resulting in endothelial dysfunction. CONCLUSIONS: \u00a0To some extent, this study helps clinicians make diagnosis and treatment plans in advance and improve prognosis. This method could be used in the numerical simulation of practical models.<\/jats:p>","DOI":"10.3233\/bme-221418","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T13:48:52Z","timestamp":1663336132000},"page":"235-246","source":"Crossref","is-referenced-by-count":0,"title":["Numerical analysis of hemodynamics in pulmonary artery stenosis"],"prefix":"10.1177","volume":"34","author":[{"given":"Fan","family":"He","sequence":"first","affiliation":[{"name":"School of Science, , , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Science, , , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Hua","sequence":"additional","affiliation":[{"name":", , State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, , , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Guo","sequence":"additional","affiliation":[{"name":", , State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, , , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/BME-221418_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/2045894020954310","article-title":"Peripheral pulmonary stenosis with Noonan syndrome treated by balloon pulmonary angioplasty","volume":"10","author":"Ko","year":"2020","journal-title":"Pulmonary Circulation"},{"issue":"5","key":"10.3233\/BME-221418_ref2","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s10237-014-0563-y","article-title":"Numerical simulation of blood flow and pressure drop in the pulmonary arterial and venous circulation","volume":"13","author":"Qureshi","year":"2014","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"3","key":"10.3233\/BME-221418_ref3","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1007\/s10439-010-9901-0","article-title":"Image-based modeling of blood flow and vessel wall dynamics: Applications, methods and future directions","volume":"38","author":"Taylor","year":"2010","journal-title":"Annals of Biomedical Engineering"},{"issue":"1","key":"10.3233\/BME-221418_ref4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1166\/asl.2012.3274","article-title":"Numerical investigation of non-Newtonian pulsatile blood flow in atherosclerotic coronary artery","volume":"17","author":"Ghaffari","year":"2012","journal-title":"Advanced Science Letters"},{"issue":"5-6","key":"10.3233\/BME-221418_ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/BME-191072","article-title":"Numerical investigation of unsteady pulsatile Newtonian\/non-Newtonian blood flow through curved stenosed arteries","volume":"30","author":"Lakzian","year":"2020","journal-title":"Bio-medical Materials and Engineering"},{"issue":"4","key":"10.3233\/BME-221418_ref6","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/03091900050163445","article-title":"Computational modelling of blood flow through curved stenosed arteries","volume":"24","author":"Yao","year":"2000","journal-title":"Journal of Medical Engineering and Technology"},{"key":"10.3233\/BME-221418_ref7","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0021-9290(99)00015-9","article-title":"The infuence of the non-Newtonian properties of blood on the fow inlarge arteries: Steady fow in a carotid bifurcation model","volume":"32","author":"Gijsen","year":"1999","journal-title":"Journal of Biomechanics"},{"issue":"12","key":"10.3233\/BME-221418_ref8","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1115\/1.4034830","article-title":"A zero dimensional model and protocol for simulating patient-specific pulmonary hemodynamics from limited clinical data","volume":"138","author":"Kheyfets","year":"2016","journal-title":"Journal of Biomechanical Engineering"},{"issue":"159","key":"10.3233\/BME-221418_ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rsif.2019.0284","article-title":"Influence of image segmentation on one-dimensional fluid dynamics predictions in the mouse pulmonary arteries","volume":"16","author":"Colebank","year":"2019","journal-title":"Journal of the Royal Society Interface"},{"issue":"1","key":"10.3233\/BME-221418_ref10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/jth.14629","article-title":"Sex-specific differences in chronic thromboembolic pulmonary hypertension. Results from the European CTEPH registry","volume":"18","author":"Barco","year":"2020","journal-title":"Journal of Thrombosis and Haemostasis"},{"issue":"9","key":"10.3233\/BME-221418_ref11","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s10439-018-2047-1","article-title":"Computational fluid dynamics modeling of the human pulmonary arteries with experimental validation","volume":"46","author":"Bordones","year":"2018","journal-title":"Annals of Biomedical Engineering"},{"issue":"7","key":"10.3233\/BME-221418_ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cnm.3208","article-title":"Simulation of unsteady blood flows in a patient-specific compliant pulmonary artery with a highly parallel monolithically coupled fluid-structure interaction algorithm","volume":"35","author":"Kong","year":"2019","journal-title":"International Journal for Numerical Methods in Biomedical Engineering"},{"issue":"19","key":"10.3233\/BME-221418_ref13","first-page":"5320","article-title":"Effects of stenosis on hemodynamics within pulmonary artery models: Numerical simulation studies","volume":"20","author":"Wan","year":"2008","journal-title":"Journal of System Simulation"},{"issue":"3","key":"10.3233\/BME-221418_ref14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/S0022-5223(19)39931-3","article-title":"The role of multiple noncritical arterial stenoses in the pathogenesis of ischemia","volume":"73","author":"Karayannacos","year":"1977","journal-title":"The Journal of Thoracic Cardiovasclar Surgery"},{"issue":"4","key":"10.3233\/BME-221418_ref15","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.bbe.2020.08.006","article-title":"Numerical investigation of renal artery hemodynamics based on the physiological response to renal artery stenosis","volume":"40","author":"Andayesh","year":"2020","journal-title":"Biocybernetics and Biomedical Engineering"},{"issue":"4","key":"10.3233\/BME-221418_ref16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1007\/s10439-006-9240-3","article-title":"Morphometry-based impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries","volume":"35","author":"Spilker","year":"2007","journal-title":"Annals of Biomedical Engineering"},{"issue":"4","key":"10.3233\/BME-221418_ref17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/icvts\/ivu202","article-title":"Computational fluid dynamics of the right ventricular outflow tract and of the pulmonary artery: A bench model of flow dynamics","volume":"19","author":"Mosbahi","year":"2014","journal-title":"Interactive Cardiovascular and Thoracic Surgery"},{"issue":"12","key":"10.3233\/BME-221418_ref18","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.jbiomech.2007.01.008","article-title":"Fluid-structure interaction in a pulmonary arterial bifurcation","volume":"40","author":"Yang","year":"2007","journal-title":"Journal of Biomechanics"},{"key":"10.3233\/BME-221418_ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.medengphy.2020.09.014","article-title":"Blood flow simulations in the pulmonary bifurcation in relation to adult patients with repaired tetralogy of Fallot","volume":"85","author":"Boumpouli","year":"2020","journal-title":"Medical Engineering and Physics"},{"issue":"1","key":"10.3233\/BME-221418_ref20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1097\/00004728-198202000-00017","article-title":"CT evaluation of pulmonary artery size","volume":"6","author":"Callaghan","year":"1982","journal-title":"Journal of Computer Assisted Tomography"},{"issue":"20","key":"10.3233\/BME-221418_ref21","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S0045-7949(02)00111-6","article-title":"Simulating cyclic artery compression using a 3D unsteady model with fluid\u2013structure interactions","volume":"80","author":"Tang","year":"2002","journal-title":"Computers and Structures"},{"issue":"4","key":"10.3233\/BME-221418_ref22","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1115\/1.3138235","article-title":"The Fluid Mechanics of Large Blood Vessels","volume":"102","author":"Pedley","year":"1980","journal-title":"Journal of Biomechanical Engineering"},{"issue":"3","key":"10.3233\/BME-221418_ref23","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ejcts.2004.05.043","article-title":"Comparison of biomechanical and structural properties between human aortic and pulmonary valve","volume":"26","author":"Peteris","year":"2004","journal-title":"European Journal of Cardio-thoracic Surgery"},{"issue":"16","key":"10.3233\/BME-221418_ref24","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1016\/j.jbiomech.2007.06.023","article-title":"Numerical analysis of pulsatile blood flow and vessel wall mechanics in different degrees of stenoses","volume":"40","author":"Li","year":"2007","journal-title":"Journal of Biomechanics"},{"issue":"45","key":"10.3233\/BME-221418_ref25","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1016\/j.cma.2009.02.004","article-title":"Open problems in computational vascular biomechanics: Hemodynamics and arterial wall mechanics","volume":"198","author":"Taylor","year":"2009","journal-title":"Computer Methods in Applied Mechanics and Engineering"},{"key":"10.3233\/BME-221418_ref26","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.cmpb.2018.06.007","article-title":"Magnetohydrodynamic blood flow in patients with coronary artery disease","volume":"163","author":"Javadzadegan","year":"2018","journal-title":"Computer Methods and Programs in Biomedicine"},{"issue":"1","key":"10.3233\/BME-221418_ref27","doi-asserted-by":"crossref","DOI":"10.1177\/1687814021989012","article-title":"Fluid-structure interaction analysis of hemodynamics in different degrees of stenoses considering microcirculation function","volume":"13","author":"He","year":"2021","journal-title":"Advances in Mechanical Engineering"},{"issue":"7","key":"10.3233\/BME-221418_ref28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s13239-016-0269-7","article-title":"Alterations of blood flow through arteries following atherectomy and the impact on pressure variation and velocity","volume":"3","author":"Plourde","year":"2016","journal-title":"Cardiovascular Engineering Technology"},{"issue":"6","key":"10.3233\/BME-221418_ref29","first-page":"5401","article-title":"Clinical value of homodynamic numerical simulation applied in the treatment of cerebral aneurysm","volume":"14","author":"Zhang","year":"2017","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"1","key":"10.3233\/BME-221418_ref30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1152\/physrev.00047.2009","article-title":"Effects of disturbed flow on vascular en-dothelium: Pathophysiological basis and clinical perspectives","volume":"91","author":"Chiu","year":"2011","journal-title":"Physiological Reviews"},{"issue":"5","key":"10.3233\/BME-221418_ref31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.compbiomed.2006.06.006","article-title":"Flow parameters in normal left coronary artery tree. Implication to atherogenesis","volume":"37","author":"Soulis","year":"2007","journal-title":"Computers in Biology and Medicine"},{"issue":"23","key":"10.3233\/BME-221418_ref32","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1161\/CIRCULATIONAHA.105.590018","article-title":"Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress","volume":"113","author":"Cheng","year":"2006","journal-title":"Circulation"},{"issue":"3","key":"10.3233\/BME-221418_ref33","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1161\/CIRCRESAHA.113.301562","article-title":"A novel mouse model of atherosclerotic plaque instability for drug testing and mechanistic \/therapeutic discoveries using gene and mi-croRNA expression profiling","volume":"113","author":"Chen","year":"2013","journal-title":"Circulation Research"},{"issue":"1","key":"10.3233\/BME-221418_ref34","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1196\/annals.1302.031","article-title":"Dynamics of blood flow and platelet transport in pathological vessels","volume":"1015","author":"Einav","year":"2004","journal-title":"Annals of the New York Academy of Sciences"}],"container-title":["Bio-Medical Materials and Engineering"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BME-221418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:24:22Z","timestamp":1777382662000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BME-221418"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,16]]},"references-count":34,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/bme-221418","relation":{},"ISSN":["0959-2989","1878-3619"],"issn-type":[{"value":"0959-2989","type":"print"},{"value":"1878-3619","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,16]]}}}