{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:15:15Z","timestamp":1777464915134,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BME"],"published-print":{"date-parts":[[2023,11,10]]},"abstract":"<jats:p>BACKGROUND: Currently, quadrilateral anterior cervical plate (QACP) is a highly prevalent ACP. OBJECTIVE: This study aims to design a novel ACP using topology optimization (TOACP). METHODS: A completed model for C1\u2013C7 cervical segments was established and validated. QACP and TOACP cage systems were implanted within two cervical vertebrae models, respectively, and peak stresses and stress distributions for screw, plate, endplate and cage displacement were investigated under differing exercise modes. RESULTS: Stress levels upon QACP screw were maximized for over-extension exercise (243.3\u00a0MPa, 3.35% &gt; TOACP screw). Stress level upon TOACP plate was maximized for over-extension exercise (118.2\u00a0MPa, 7.26% &gt; QACP screw). Following QACP cage system implantation, stress on endplate and cage displacement were maximized for extension exercise, which were 27.1%, and 6.3% &gt; TOACP cage system, respectively. Finite element analysis results revealed that topological optimization of the plate can effectively reduce screw stress, thereby enhancing cervical segments\u2019 stability during surgery. Furthermore, stress on endplate and cage displacement decreased, indicating great potential in cage sinking and fusion enhancement. CONCLUSIONS: Topological optimization of the plate equips the cage system with advantages in clinical applications and biomechanical performance, providing alternative solutions and a theoretical basis for ACP design.<\/jats:p>","DOI":"10.3233\/bme-230019","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T12:11:30Z","timestamp":1684843890000},"page":"525-535","source":"Crossref","is-referenced-by-count":2,"title":["Topological optimization of anterior cervical plate (ACP) and its biomechanic characteristics"],"prefix":"10.1177","volume":"34","author":[{"given":"Peng","family":"Ye","sequence":"first","affiliation":[{"name":", Xinjiang University, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongchang","family":"Fu","sequence":"additional","affiliation":[{"name":", Xinjiang University, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoyao","family":"Wang","sequence":"additional","affiliation":[{"name":", Xinjiang University, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"03","key":"10.3233\/BME-230019_ref1","first-page":"211","article-title":"A review of cervical spondylosis research in the last decade","volume":"35","author":"Wang","year":"2014","journal-title":"Journal of Neck and Low Back Pain"},{"key":"10.3233\/BME-230019_ref2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jocn.2017.10.022","article-title":"Is stand alone PEEK cage the gold standard in multilevel anterior cervical discectomy and fusion (ACDF)? 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