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METHODS: The isolation of exosomes was done by ultracentrifugation methods and the FV was loaded into the exosomes by electroporation method. RESULTS: The Exo\/FV was found to be spherical with diameter ranges from 20 to 30\u00a0nm and they were tested for biocompatibility in NHI 3T3 cell lines and found to be effective. This research investigated in\u00a0vivo hypertension in mice induced by L-NAME and treated with FV and Exo\/FV and found that AChE and MAO determine mice\u2019s redox state tends to reduce blood pressure. Increased non-protein thiol (NP-SH) and decreased lipid peroxidation were also found, and PDE-5, ACE, Arginase, and MDA activity has also been tested. CONCLUSION: This analysis showed that Exo\/FV effectively treated hypertension during pregnancy.<\/jats:p>","DOI":"10.3233\/bme-240053","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T10:45:50Z","timestamp":1727779550000},"page":"1-18","source":"Crossref","is-referenced-by-count":1,"title":["Extract from Falcaria vulgaris loaded with exosomes for the treatment of hypertension in pregnant mice: In vitro and In vivo investigations"],"prefix":"10.1177","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[{"name":", The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan","family":"Wang","sequence":"additional","affiliation":[{"name":", The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, , 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