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METHOD: In this review article, we discuss lumbar instability as an etiology of low back pain and its treatment by prolotherapy. RESULTS: Spinal ligaments may be an underlying culprit in the development of lumbar instability with resultant low back pain and associated disorders. CONCLUSION: In these cases, adequate treatment consisting of non-biologic prolotherapy or cellular prolotherapy, including platelet rich plasma (PRP), can be beneficial in restoring spinal stability and resolving chronic low back pain.<\/jats:p>","DOI":"10.3233\/bmr-210097","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T12:08:46Z","timestamp":1640088526000},"page":"701-712","source":"Crossref","is-referenced-by-count":41,"title":["Lumbar instability as an etiology of low back pain and its treatment by prolotherapy: A review"],"prefix":"10.1177","volume":"35","author":[{"given":"Ross A.","family":"Hauser","sequence":"first","affiliation":[{"name":"Caring Medical Florida, Fort Myers, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Matias","sequence":"additional","affiliation":[{"name":"Caring Medical Florida, Fort Myers, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Woznica","sequence":"additional","affiliation":[{"name":"Woz Wellness, Chicago, IL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Rawlings","sequence":"additional","affiliation":[{"name":"Caring Medical Florida, Fort Myers, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara A.","family":"Woldin","sequence":"additional","affiliation":[{"name":"Caring Medical Florida, Fort Myers, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/BMR-210097_ref1","unstructured":"Weinstein SI, Yelin EH, Watkins-Castillo SI. 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