{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:32:28Z","timestamp":1777465948907,"version":"3.51.4"},"reference-count":38,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMR"],"published-print":{"date-parts":[[2022,11,12]]},"abstract":"<jats:p>BACKGROUND: 25-hydroxy vitamin D (25OHD) deficiency is associated with cardiovascular disease and poor physical performance. OBJECTIVE: To assign the effect of 25OHD level on cardiac rehabilitation (CR) in patients with coronary artery disease (CAD). METHODS: One-hundred-thirty-five patients with CAD who underwent a CR programme were enrolled in this retrospective study. Patients were divided into two-group according to 25OHD level (Group 1: &lt; 20\u00a0ng\/dl; Group 2: \u2a7e 20\u00a0ng\/dl). All patients received CR for 30 sessions. Each participant performed 40\u00a0minutes of aerobic exercise with a cycloergometer followed by muscle strengthening exercises. The patients were evaluated before and after CR by a pulmonary function test (PFT) and a cardiopulmonary exercise test (CPET). RESULTS: There were 77 (57%) patients in Group 1 and 58 patients (43%) in Group 2. Demographic characteristics between the groups were similar. Pre- and post-rehabilitation CPET parameters were lower in Group 1 (p&lt; 0.05). Both groups had significant improvement in CPET (p&lt; 0.05). Post-rehabilitation PFT parameters (FEV1, FVC) were higher in Group\u00a02 (p&lt; 0.05). There was a positive correlation between the 25OHD-level and the CPET-PFT parameters (p&lt; 0.05). CONCLUSION: 25OHD deficiency in patients with CAD reduces the response to CR. It also affects respiratory function according to the FEV1, FVC parameters. In patients scheduled for CR, 25OHD-levels should be evaluated, and any deficiency corrected.<\/jats:p>","DOI":"10.3233\/bmr-210355","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T11:46:38Z","timestamp":1655207198000},"page":"1373-1380","source":"Crossref","is-referenced-by-count":0,"title":["The effect of vitamin D level on cardiac rehabilitation in patients with coronary artery disease"],"prefix":"10.1177","volume":"35","author":[{"given":"Ayla Cagliyan","family":"Turk","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hitit University, Corum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeliz Bahar","family":"Ozdemir","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Abdulhamid Han Training and Research Hospital, Health Sciences University Sultan 2, Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuf","family":"Karavelioglu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Hitit University, Corum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mucahit","family":"Yetim","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine, Hitit University, Corum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusun","family":"Sahin","sequence":"additional","affiliation":[{"name":"Physical Medicine and Rehabilitation Physician, Denizli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"3","key":"10.3233\/BMR-210355_ref1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/CIRCULATIONAHA.108.191259","article-title":"Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee","volume":"119","author":"Lloyd-Jones","year":"2009","journal-title":"Circulation."},{"issue":"11","key":"10.3233\/BMR-210355_ref2","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/sj.jhh.1001909","article-title":"The prevalence of hypertension and its association with other cardiovascular disease risk factors in a representative sample of the Lebanese population","volume":"19","author":"Tohme","year":"2005","journal-title":"J Hum Hypertens."},{"issue":"3","key":"10.3233\/BMR-210355_ref3","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med."},{"issue":"1","key":"10.3233\/BMR-210355_ref4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pbiomolbio.2006.02.001","article-title":"Vitamin D and disease prevention with special reference to cardiovascular disease","volume":"92","author":"Zittermann","year":"2006","journal-title":"Prog Biophys Mol Biol."},{"key":"10.3233\/BMR-210355_ref5","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11154-019-09532-w","article-title":"Consensus statement from 2nd International Conference on Controversies in Vitamin D","volume":"21","author":"Giustina","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"10.3233\/BMR-210355_ref6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.rehab.2016.01.012","article-title":"Vitamin D deficiency related to physical capacity during cardiac rehabilitation","volume":"60","author":"Ucay","year":"2017","journal-title":"Ann Phys Rehabil Med."},{"issue":"9","key":"10.3233\/BMR-210355_ref7","doi-asserted-by":"crossref","first-page":"744","DOI":"10.5152\/akd.2014.5637","article-title":"Lower serum 25-hydroxyvitamin D level is associated with impaired myocardial performance and left ventricle hypertrophy in newly diagnosed hypertensive patients","volume":"15","author":"\u015eeker","year":"2015","journal-title":"Anatol J Cardiol."},{"issue":"1","key":"10.3233\/BMR-210355_ref8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/138945011793591635","article-title":"Vitamin D: evolutionary, physiological and health perspectives","volume":"12","author":"Holick","year":"2011","journal-title":"Curr Drug Targets."},{"key":"10.3233\/BMR-210355_ref9","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1113\/jphysiol.2011.214726","article-title":"Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats","volume":"589","author":"Tare","year":"2011","journal-title":"J Physiol."},{"issue":"3","key":"10.3233\/BMR-210355_ref10","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.0000151788.08740.5C","article-title":"Cardiac rehabilitation and secondary prevention of coronary heart disease","volume":"111","author":"Leon","year":"2005","journal-title":"Circulation."},{"issue":"13","key":"10.3233\/BMR-210355_ref11","first-page":"e100","article-title":"ACCF\/AHA\/ACP 2009 Competence and Training Statement: A Curriculum on Prevention of Cardiovascular Disease","volume":"120","author":"Merz","year":"2009","journal-title":"Circulation."},{"issue":"1","key":"10.3233\/BMR-210355_ref12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/2040622310381934","article-title":"Effects of vitamin D on muscle function and performance: a review of evidence from randomized controlled trials","volume":"2","author":"Rejnmark","year":"2011","journal-title":"Ther Adv Chronic Dis."},{"issue":"5","key":"10.3233\/BMR-210355_ref13","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1046\/j.1532-5415.2002.50219.x","article-title":"Low serum vitamin D does not predict new disability or loss of muscle strength in older women","volume":"50","author":"Verreault","year":"2002","journal-title":"J Am Geriatr Soc."},{"issue":"2","key":"10.3233\/BMR-210355_ref14","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1532-5415.2009.02118.x","article-title":"Vitamin D deficiency-related quadriceps weakness: results of the Epidemiologie De l\u2019Osteoporose cohort","volume":"57","author":"Annweiler","year":"2009","journal-title":"J Am Geriatr Soc."},{"issue":"4","key":"10.3233\/BMR-210355_ref15","doi-asserted-by":"crossref","first-page":"e34950","DOI":"10.1371\/journal.pone.0034950","article-title":"Vitamin D and physical performance in elderly subjects: the ProV.A.","volume":"7","author":"Toffanello","year":"2012","journal-title":"study. PloS One."},{"issue":"2","key":"10.3233\/BMR-210355_ref16","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"ATS\/ERS Task Force","volume":"26","author":"Miller","year":"2005","journal-title":"Standardisation of spirometry. Eur Respir J."},{"key":"10.3233\/BMR-210355_ref17","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1183\/09041950.041s1693","article-title":"Standardization of the measurement of transfer factor (diffusing capacity). Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society","volume":"16","author":"Cotes","year":"1993","journal-title":"Eur Respir J Suppl."},{"key":"10.3233\/BMR-210355_ref18","doi-asserted-by":"crossref","unstructured":"American Thoracic Society; American College of Chest Physicians. ATS\/ACCP Statement on cardiopulmonary exercise testing. Am J Respir Crit Care Med. 2003; 167(2): 211-77.","DOI":"10.1164\/rccm.167.2.211"},{"key":"10.3233\/BMR-210355_ref19","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1001\/archinte.1916.00080130010002","article-title":"A Formula to Estimate the Approximate Surface Area if Height and Weight Be Known","volume":"17","author":"Du Bois","year":"1916","journal-title":"Archives of Internal Medicine."},{"issue":"3","key":"10.3233\/BMR-210355_ref20","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/ajcn\/80.3.752","article-title":"Higher 25- hydroxyvitamin D concentrations are associated with better lower extremity function in both active and inactive persons aged N or = 60 y","volume":"80","author":"Bischoff-Ferrari","year":"2004","journal-title":"Am J Clin Nutr."},{"issue":"10","key":"10.3233\/BMR-210355_ref21","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1210\/jc.2008-0784","article-title":"Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography","volume":"93","author":"Pilz","year":"2008","journal-title":"J Clin Endocrinol Metab."},{"issue":"3","key":"10.3233\/BMR-210355_ref22","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s12020-017-1282-9","article-title":"Hypovitaminosis D in patients with heart failure: effects on functional capacity and patients\u2019 survival","volume":"58","author":"Saponaro","year":"2017","journal-title":"Endocrine."},{"issue":"4","key":"10.3233\/BMR-210355_ref23","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/eurjhf\/hfr175","article-title":"Vitamin D deficiency is a predictor of reduced survival in patients with heart failure; Vitamin D supplementation improves outcome","volume":"14","author":"Gotsman","year":"2012","journal-title":"Eur J Heart Fail."},{"issue":"3","key":"10.3233\/BMR-210355_ref24","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1532-5415.2007.01601.x","article-title":"The association between vitamin D and inflammation with the 6-minute walk and frailty in patients with heart failure","volume":"56","author":"Boxer","year":"2008","journal-title":"J Am Geriatr Soc."},{"issue":"2","key":"10.3233\/BMR-210355_ref25","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/CIRCHEARTFAILURE.109.907899","article-title":"The effects of vitamin D supplementation on physical function and quality of life in older patients with heart failure: a randomized controlled trial","volume":"3","author":"Witham","year":"2010","journal-title":"Circ Heart Fail."},{"issue":"5","key":"10.3233\/BMR-210355_ref26","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.ahj.2010.08.004","article-title":"Serum 25-hydroxyvitamin D concentration is associated with functional capacity in older adults with heart failure","volume":"160","author":"Boxer","year":"2010","journal-title":"Am Heart J."},{"key":"10.3233\/BMR-210355_ref27","doi-asserted-by":"crossref","unstructured":"Amin A, Minaee S, Chitsazan M, Naderi N, Taghavi S, Ardeshiri M. Can vitamin D supplementation improve the severity of congestive heart failure? Congest Heart Fail. 2013; 19(4): E22-8.","DOI":"10.1111\/chf.12026"},{"key":"10.3233\/BMR-210355_ref28","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fphys.2014.00145","article-title":"The role of vitamin D in skeletal and cardiac muscle function","volume":"5","author":"Polly","year":"2014","journal-title":"Front Physiol."},{"issue":"3","key":"10.3233\/BMR-210355_ref29","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jsbmb.2006.12.099","article-title":"1,25(OH)2- vitamin D3 actions on cell proliferation, size, gene expression, and receptor localization, in the HL-1 cardiac myocyte","volume":"103","author":"Nibbelink","year":"2007","journal-title":"J Steroid Biochem Mol Biol."},{"issue":"1","key":"10.3233\/BMR-210355_ref30","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.atherosclerosis.2005.06.046","article-title":"Effects of Vitamin D analogs on gene expression profiling in human coronary artery smooth muscle cells","volume":"186","author":"Wu-Wong","year":"2006","journal-title":"Atherosclerosis."},{"issue":"4","key":"10.3233\/BMR-210355_ref31","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ajcn\/75.4.611","article-title":"Vitamin D deficiency, muscle function, and falls in elderly people","volume":"75","author":"Janssen","year":"2002","journal-title":"Am J Clin Nutr."},{"issue":"1","key":"10.3233\/BMR-210355_ref32","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1023\/A:1017535728844","article-title":"In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue","volume":"33","author":"Bischoff","year":"2001","journal-title":"Histochem J."},{"issue":"1","key":"10.3233\/BMR-210355_ref33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/BF03324819","article-title":"Muscle strength and mobility in vitamin D-insufficient female geriatric patients: a randomized controlled trial on vitamin D and calcium supplementation","volume":"22","author":"Janssen","year":"2010","journal-title":"Aging Clin Exp Res."},{"issue":"1","key":"10.3233\/BMR-210355_ref34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1136\/thoraxjnl-2013-203682","article-title":"Plasma 25-hydroxyvitamin D, Lung Function and Risk of Chronic Obstructive Pulmonary Disease","volume":"69","author":"Afzal","year":"2014","journal-title":"Thorax."},{"issue":"4","key":"10.3233\/BMR-210355_ref35","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.arbres.2016.09.010","article-title":"Association Between Severe Vitamin D Deficiency, Lung Function and Asthma Control","volume":"53","author":"Beyhan-Sagmen","year":"2017","journal-title":"Arch Bronconeumol."},{"issue":"1","key":"10.3233\/BMR-210355_ref36","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1590\/2359-3997000000211","article-title":"Effects of vitamin D supplementation on pulmonary function in postmenopausal women following an aquatic exercise program","volume":"61","author":"Nolasco","year":"2017","journal-title":"Arch Endocrinol Metab."},{"issue":"12","key":"10.3233\/BMR-210355_ref37","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.3390\/nu9121353","article-title":"Effect of Monthly, High-Dose, Long-Term Vitamin D on Lung Function: A Randomized Controlled Trial","volume":"9","author":"Sluyter","year":"2017","journal-title":"Nutrients."},{"issue":"1","key":"10.3233\/BMR-210355_ref38","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1465-9921-12-31","article-title":"The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer","volume":"12","author":"Herr","year":"2011","journal-title":"Respir Res."}],"container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BMR-210355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:27:10Z","timestamp":1777382830000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BMR-210355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,12]]},"references-count":38,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3233\/bmr-210355","relation":{},"ISSN":["1878-6324","1053-8127"],"issn-type":[{"value":"1878-6324","type":"electronic"},{"value":"1053-8127","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11,12]]}}}