{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:36:11Z","timestamp":1777466171921,"version":"3.51.4"},"reference-count":43,"publisher":"SAGE Publications","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMR"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>BACKGROUND: Ultrasound has a long history as a diagnostic and therapeutic tool. Low-intensity pulsed ultrasound (LIPUS), whose intensity is below 300 mW\/cm2, has been widely used in orthopedic rehabilitation treatment. However, the detailed bioeffects and underlying mechanisms of LIPUS treatment need to be explored. OBJECTIVE: To make a comprehensive view of the field, bibliometric and visualization analysis was used to reveal the global research trends of LIPUS in orthopedics and rehabilitation treatment between 1994 and 2023. METHODS: All literature data on LIPUS were retrieved from the Web of Science Core Collection database. VOSviewer and CiteSpace were applied for the bibliometric and visualization analysis. RESULTS: A total of 760 publications were included. The distribution of publications generally showed an unstable rising trend. China had the highest number of publications (28.0%), and Chong Qing Medical University was the organization with the highest number of publications (5.8%). Ultrasound in Medicine and Biology had the highest number of publications (8.8%), while BMJ-British Medical Journal had the highest impact factor among the retrieved journals. Ling Qin from the Chinese University of Hong Kong was the most active researcher. Our overlay visualization map showed that the keywords such as pain, knee osteoarthritis, apoptosis, chondrocytes, cartilage, and autophagy, which link to osteoarthritis, have becoming the new research trends and hotspots. CONCLUSION: LIPUS is a popular and increasingly important area of orthopedic rehabilitation, and collaboration of authors from different countries should be further strengthened. Predictably, clinical application of LIPUS on chronic inflammation-related diseases and regenerative medicine, and in-depth biological mechanisms are the orientations of LIPUS in orthopedic rehabilitation treatment.<\/jats:p>","DOI":"10.3233\/bmr-230273","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T10:53:24Z","timestamp":1715684004000},"page":"1189-1203","source":"Crossref","is-referenced-by-count":1,"title":["Research trends and perspective of low-intensity pulsed ultrasound in orthopedic rehabilitation treatment based on Web of Science: A bibliometric analysis"],"prefix":"10.1177","volume":"37","author":[{"given":"Bin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China"},{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"},{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Zeng","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"},{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"},{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keyan","family":"Song","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangbo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Xi-Jing Hospital, Air Force Medical University (Fourth Military Medical University), Xi\u2019an, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijuan","family":"Shang","sequence":"additional","affiliation":[{"name":"Rehabilitation Department, Key Specialty of Neck and Low Back Pain Rehabilitation, Xingcheng Special Duty Sanatorium, Xingcheng, Liaoning, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhong","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Wound Repair and Rehabilitation Medicine, Center of Bone Metabolism and Repair, Laboratory for Prevention and Rehabilitation of Training Injuries, State Key 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Shortening of Overall Orthodontic Treatment Duration with Low-Intensity Pulsed Ultrasound (LIPUS). J Clin Med. 2020; 9(5).","DOI":"10.3390\/jcm9051303"},{"issue":"7","key":"10.3233\/BMR-230273_ref18","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1080\/15548627.2019.1664705","article-title":"SQSTM1-dependent autophagic degradation of PKM2 inhibits the production of mature IL1B\/IL-1beta and contributes to LIPUS-mediated anti-inflammatory effect","volume":"16","author":"Zhang","year":"2020","journal-title":"Autophagy."},{"issue":"3","key":"10.3233\/BMR-230273_ref19","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/2211-5463.12801","article-title":"Low-intensity pulsed ultrasound inhibits VEGFA expression in chondrocytes and protects against cartilage degeneration in experimental osteoarthritis","volume":"10","author":"Guan","year":"2020","journal-title":"FEBS Open Bio."},{"key":"10.3233\/BMR-230273_ref20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jot.2021.08.002","article-title":"Low-intensity pulsed ultrasound inhibits fibroblast-like synoviocyte proliferation and reduces synovial fibrosis by regulating Wnt\/beta-catenin signaling","volume":"30","author":"Liao","year":"2021","journal-title":"J Orthop Translat."},{"issue":"4","key":"10.3233\/BMR-230273_ref21","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.gendis.2022.06.009","article-title":"Extracellular vesicles derived from human dental mesenchymal stem cells stimulated with low-intensity pulsed ultrasound alleviate inflammation-induced bone loss in a mouse model of periodontitis","volume":"10","author":"Zhang","year":"2023","journal-title":"Genes Dis."},{"key":"10.3233\/BMR-230273_ref22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.jot.2023.09.002","article-title":"Daily low-intensity pulsed ultrasound stimulation mitigates joint degradation and pain in a post-traumatic osteoarthritis rat model","volume":"44","author":"Lee","year":"2024","journal-title":"J Orthop Translat."},{"issue":"10300","key":"10.3233\/BMR-230273_ref23","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0140-6736(21)00534-1","article-title":"Parental education and inequalities in child mortality: a global systematic review and meta-analysis","volume":"398","author":"Balaj","year":"2021","journal-title":"Lancet."},{"issue":"11","key":"10.3233\/BMR-230273_ref24","doi-asserted-by":"crossref","first-page":"e1915552","DOI":"10.1001\/jamanetworkopen.2019.15552","article-title":"Assessment of Citations of the Retracted Article by Wakefield et al With Fraudulent Claims of an Association Between Vaccination and Autism","volume":"2","author":"Suelzer","year":"2019","journal-title":"JAMA Netw Open."},{"key":"10.3233\/BMR-230273_ref25","first-page":"e2308915","article-title":"A Journey of Challenges and Victories: A Bibliometric Worldview of Nanomedicine since the 21st Century","author":"Wang","year":"2023","journal-title":"Adv Mater."},{"issue":"2","key":"10.3233\/BMR-230273_ref26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s11192-009-0146-3","article-title":"Software survey: VOSviewer, a computer program for bibliometric mapping","volume":"84","author":"Eck","year":"2010","journal-title":"Scientometrics."},{"key":"10.3233\/BMR-230273_ref27","unstructured":"Synnestvedt MB, Chen C, Holmes JH. CiteSpace II: visualization and knowledge discovery in bibliographic databases. AMIA Annu Symp Proc. 2005; 2005: 724-8."},{"issue":"1","key":"10.3233\/BMR-230273_ref28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2106\/00004623-199401000-00004","article-title":"Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound","volume":"76","author":"Heckman","year":"1994","journal-title":"J Bone Joint Surg Am."},{"issue":"5","key":"10.3233\/BMR-230273_ref29","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ultras.2014.01.004","article-title":"Stimulation of bone repair with ultrasound: a review of the possible mechanic effects","volume":"54","author":"Padilla","year":"2014","journal-title":"Ultrasonics."},{"key":"10.3233\/BMR-230273_ref30","doi-asserted-by":"crossref","unstructured":"Lin L, Zhang M, Song Q, Cheng X, Shao Z, Yan H, et al. Cuistow: Chinese Unique Inlay Bristow: A Novel Arthroscopic Surgical Procedure for Treatment of Recurrent Anterior Shoulder Instability with a Minimum 3-Year Follow-Up. 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by Regulating Autophagy-Mediated Exosome Release","volume":"13","author":"Xia","year":"2022","journal-title":"Cartilage."},{"issue":"6","key":"10.3233\/BMR-230273_ref34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0301-5629(82)90121-1","article-title":"The action of low-intensity pulsed ultrasound on amphibian embryonic tissues","volume":"8","author":"Sarvazyan","year":"1982","journal-title":"Ultrasound Med Biol."},{"key":"10.3233\/BMR-230273_ref35","first-page":"i5351","article-title":"Re-evaluation of low intensity pulsed ultrasound in treatment of tibial fractures (TRUST): randomized clinical trial","volume":"355","author":"Group","year":"2016","journal-title":"BMJ."},{"key":"10.3233\/BMR-230273_ref36","doi-asserted-by":"crossref","first-page":"j656","DOI":"10.1136\/bmj.j656","article-title":"Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials","volume":"356","author":"Schandelmaier","year":"2017","journal-title":"BMJ."},{"issue":"7","key":"10.3233\/BMR-230273_ref37","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/j.injury.2017.05.016","article-title":"Healing of fracture nonunions treated with low-intensity pulsed ultrasound (LIPUS): A systematic review and meta-analysis","volume":"48","author":"Leighton","year":"2017","journal-title":"Injury."},{"issue":"1","key":"10.3233\/BMR-230273_ref38","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s12891-021-04322-5","article-title":"Low intensity pulsed ultrasound (LIPUS) use for the management of instrumented, infected, and fragility non-unions: a systematic review and meta-analysis of healing proportions","volume":"22","author":"Leighton","year":"2021","journal-title":"BMC Musculoskelet Disord."},{"issue":"4","key":"10.3233\/BMR-230273_ref39","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/bem.22258","article-title":"Effects and Mechanisms of Exogenous Electromagnetic Field on Bone Cells: A Review","volume":"41","author":"Zhang","year":"2020","journal-title":"Bioelectromagnetics."},{"key":"10.3233\/BMR-230273_ref40","doi-asserted-by":"crossref","first-page":"22773","DOI":"10.1038\/srep22773","article-title":"Low-intensity pulsed ultrasound treatment improved the rate of autograft peripheral nerve regeneration in rat","volume":"6","author":"Jiang","year":"2016","journal-title":"Sci Rep."},{"issue":"10171","key":"10.3233\/BMR-230273_ref41","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S0140-6736(18)32995-7","article-title":"Factors affecting sex-related reporting in medical research: a cross-disciplinary bibliometric analysis","volume":"393","author":"Sugimoto","year":"2019","journal-title":"Lancet."},{"issue":"1","key":"10.3233\/BMR-230273_ref42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1186\/s13018-021-02739-1","article-title":"LIPUS inhibits inflammation and catabolism through the NF-kappaB pathway in human degenerative nucleus pulposus cells","volume":"16","author":"Yi","year":"2021","journal-title":"J Orthop Surg Res."},{"issue":"5","key":"10.3233\/BMR-230273_ref43","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.ultrasmedbio.2022.01.008","article-title":"Regenerative Effect of Low-Intensity Pulsed Ultrasound and Platelet-Rich Plasma on the Joint Friction and Biomechanical Properties of Cartilage: A Non-traumatic Osteoarthritis Model in the Guinea Pig","volume":"48","author":"Tavakoli","year":"2022","journal-title":"Ultrasound Med Biol."}],"container-title":["Journal of Back and Musculoskeletal 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