{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:28Z","timestamp":1787025868189,"version":"build-2736575974"},"reference-count":36,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T00:00:00Z","timestamp":1725321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMR"],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:p>BACKGROUND: The effect of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion (LIF) for lumbar degenerative diseases is not well known. OBJECTIVE: This study aimed to evaluate the effect of perioperative anti-osteoporosis treatment in the patients with osteoporosis and LIF. METHODS: From January to December 2022, patients were divided into three groups according to the inclusive criteria: the normal group (Group A), the osteopenia group (Group B) and the osteoporosis group (Group C). Quantitative computed tomography (QCT), height of the intervertebral space (HIS), segmental sagittal angle (SSA), visual analogue scale (VAS) score and Oswestry Disability Index (ODI) were compared between the groups at the follow-up time. The serum Ca2 + , osteocalcin (OC), propeptide of type I procollagen (PINP) C-terminal cross-linking telopeptide of type I collagen (\u03b2-CTX) and 25-OH vitamin D (25-OH VD) levels were compared between the groups at the time of follow-up. Interbody fusion was graded on the X-ray and CT images at the follow-up time. RESULTS: There were 165 patients in this study. There were significant differences in the mean age, mean score, HIS and SSA between the groups at the different follow-up times. There were significant differences in the concentrations of serum Ca2 + , OC, \u03b2-CTX, 25-OH VD and PINP at the sixth month after surgery between the groups. There were significant differences in the concentrations of serum Ca2 + , \u03b2-CTX and 25-OH VD between the pre-surgery and at six months after surgery in Group B and \u03b2-CTX and 25-OH VD in Group C. There was a significant difference in the degree of fusion between Group B and C (\u03c72= 5.6243, P&lt; 0.05). CONCLUSION: In elderly patients with LIF and osteoporosis, anti-osteoporosis therapy could reduce bone resorption and thus facilitate fusion. Anti-osteoporosis medication tends to enhance radiological, functional, and fusion short-term outcomes.<\/jats:p>","DOI":"10.3233\/bmr-230381","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T12:10:39Z","timestamp":1727093439000},"page":"1277-1287","source":"Crossref","is-referenced-by-count":4,"title":["Effects of anti-osteoporosis treatment in elderly patients with osteoporosis and lumbar discectomy and fusion"],"prefix":"10.1177","volume":"37","author":[{"given":"Tao","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyong","family":"Shou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghui","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"16","key":"10.3233\/BMR-230381_ref1","doi-asserted-by":"publisher","first-page":"1918","DOI":"10.1097\/00007632-199608150-00018","article-title":"Semirigid instrumentation in the management of lumbar spinal conditions combined with circumferential fusion","volume":"21","author":"Gertzbein","year":"1996","journal-title":"A multicenter study. Spine (Phila Pa 1976)"},{"issue":"16 Suppl","key":"10.3233\/BMR-230381_ref2","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1097\/01.brs.0000174559.13749.83","article-title":"Current treatment strategies for the painful lumbar motion segment: posterolateral fusion versus interbody fusion","volume":"30","author":"Wang","year":"2005","journal-title":"Spine (Phila Pa 1976)"},{"issue":"22","key":"10.3233\/BMR-230381_ref3","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1097\/BRS.0000000000002207","article-title":"Trends, complications, and costs for hospital admission and surgery for lumbar spinal stenosis","volume":"42","author":"Machado","year":"2017","journal-title":"Spine (Phila Pa 1976)"},{"issue":"1","key":"10.3233\/BMR-230381_ref4","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1177\/2192568218818164","article-title":"Screw-related complications after instrumentation of the osteoporotic spine: a systematic literature review with meta-analysis","volume":"10","author":"Rometsch","year":"2020","journal-title":"Global Spine J"},{"issue":"17","key":"10.3233\/BMR-230381_ref5","doi-asserted-by":"publisher","first-page":"e3455","DOI":"10.1097\/MD.0000000000003455","article-title":"Impact of instrumented spinal fusion on the development of vertebral compression fracture","volume":"95","author":"Chiu","year":"2016","journal-title":"Medicine (Baltimore)"},{"issue":"10","key":"10.3233\/BMR-230381_ref6","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1302\/0301-620X.97B10.34927","article-title":"Impact of lumbar instrumented circumferential fusion on the development of adjacent vertebral compression fracture","volume":"97-B","author":"Li","year":"2015","journal-title":"Bone Joint J"},{"issue":"4","key":"10.3233\/BMR-230381_ref7","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1097\/00007632-199702150-00012","article-title":"The spondylolytic vertebra and its adjacent segment. Mobility measured before and after posterolateral fusion","volume":"22","author":"Axelsson","year":"1997","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"10.3233\/BMR-230381_ref8","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s005860100278","article-title":"Evaluation of the mobility of adjacent segments after posterior thoracolumbar fixation: a biomechanical study","volume":"10","author":"Bastian","year":"2001","journal-title":"Eur Spine J"},{"issue":"15","key":"10.3233\/BMR-230381_ref9","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1097\/00007632-199508000-00005","article-title":"Early changes in bone mineral density above a combined anteroposterior L4-S1 lumbar spinal fusion. A clinical investigation","volume":"20","author":"Bogdanffy","year":"1995","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"10.3233\/BMR-230381_ref10","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1097\/00007632-198904000-00028","article-title":"Spinal bone density following spinal fusion","volume":"14","author":"Lipscomb","year":"1989","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.3233\/BMR-230381_ref11","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.clineuro.2016.04.014","article-title":"Early and long-term changes in adjacent vertebral body bone mineral density determined by quantitative computed tomography after posterolateral fusion with transpedicular screw fixation","volume":"145","author":"Balci","year":"2016","journal-title":"Clin Neurol Neurosurg"},{"issue":"9671","key":"10.3233\/BMR-230381_ref12","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/S0140-6736(09)60250-6","article-title":"Zoledronic acid and risedronate in the prevention and treatment of glucocorticoidinduced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial","volume":"373","author":"Reid","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"10.3233\/BMR-230381_ref13","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1177\/21925682211027833","article-title":"Effect of Zoledronic Acid on the Vertebral Body Bone Mineral Density After Instrumented Intervertebral Fusion in Postmenopausal Women With Osteoporosis","volume":"13","author":"Fan","year":"2023","journal-title":"Global Spine Journal"},{"issue":"8","key":"10.3233\/BMR-230381_ref14","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.3233\/BMR-230381_ref15","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1359\/jbmr.0809010","article-title":"Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial","volume":"24","author":"Brown","year":"2009","journal-title":"Journal of Bone & Mineral Research"},{"issue":"14","key":"10.3233\/BMR-230381_ref16","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1097\/00007632-199310001-00030","article-title":"A carbon fiber implant to aid interbody lumbar fusion. Two-year clinical results in the first 26 patients","volume":"18","author":"Brantigan","year":"1993","journal-title":"Spine (Phila Pa 1976)"},{"issue":"10","key":"10.3233\/BMR-230381_ref17","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1097\/01.BRS.0000061988.93175.74","article-title":"Radiologic assessment of interbody fusion using carbon fiber cages","volume":"28","author":"Santos","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"10.3233\/BMR-230381_ref18","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1007\/s00586-014-3642-y","article-title":"Anterior stand-alone fusion revisited: a prospective clinical, X-ray and CT investigation","volume":"24","author":"Siepe","year":"2015","journal-title":"Eur Spine J"},{"key":"10.3233\/BMR-230381_ref19","unstructured":"Chinese health promotion fundation editorial board of Chinese White Papers of osteoporosis (2009)Chinese White Papers of osteoporosis, Chin J Health Manag. 3: 148-154"},{"key":"10.3233\/BMR-230381_ref20","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s13224-011-0024-9","article-title":"Comparison of bone mineral density and its variables between premenopausal and postmenopausal women","volume":"61","author":"Mittal","year":"2011","journal-title":"J Obstet Gynaecol India"},{"issue":"5","key":"10.3233\/BMR-230381_ref21","doi-asserted-by":"publisher","first-page":"579","DOI":"10.3390\/medicina58050579","article-title":"Reinforcement of Percutaneous Pedicle Screw Fixation with Hydroxyapatite Granules in Patients with Osteoporotic Spine: Biomechanical Performance and Clinical Outcomes","volume":"58","author":"Kanno","year":"2022","journal-title":"Medicina (Kaunas)"},{"issue":"4","key":"10.3233\/BMR-230381_ref22","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s10195-011-0164-9","article-title":"Fenestrated pedicle screws for cement-augmented purchase in patients with bone softening: a review of 21 cases","volume":"12","author":"Amendola","year":"2011","journal-title":"J Orthopaed Traumatol"},{"issue":"7","key":"10.3233\/BMR-230381_ref23","doi-asserted-by":"publisher","first-page":"102791","DOI":"10.1016\/j.otsr.2020.102791","article-title":"A meta-analysis of complications associated with the use of cement-augmented pedicle screws in osteoporosis of spine","volume":"107","author":"Zhang","year":"2021","journal-title":"Orthopaedics & Traumatology: Surgery & Research"},{"issue":"2","key":"10.3233\/BMR-230381_ref24","doi-asserted-by":"publisher","first-page":"407","DOI":"10.3390\/medicina59020407","article-title":"Cardiopulmonary Cement Embolism Following Cement-Augmented Pedicle Screw Fixation: A Narrative Review","volume":"59","author":"Morimoto","year":"2023","journal-title":"Medicina (Kaunas)"},{"issue":"1","key":"10.3233\/BMR-230381_ref25","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s13018-021-02360-2","article-title":"The effect of denosumab on pedicle screw fixation: a prospective 2-year longitudinal study using finite element analysis","volume":"16","author":"Tani","year":"2021","journal-title":"Journal of Orthopaedic Surgery and Research"},{"issue":"3","key":"10.3233\/BMR-230381_ref26","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1097\/BSD.0b013e3181e9f249","article-title":"Kidneytype intervertebral spacers should be located anteriorly in cantilever transforaminal lumbar interbody fusion: analyses of risk factors for spacer subsidence for a minimum of 2 years","volume":"24","author":"Fukuta","year":"2011","journal-title":"Journal of Spinal Disorders & Techniques"},{"issue":"3","key":"10.3233\/BMR-230381_ref27","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.spinee.2012.01.021","article-title":"Influences of disc degeneration and bone mineral density on the structural properties of lumbar end plates","volume":"12","author":"Hou","year":"2012","journal-title":"The Spine Journal"},{"issue":"10","key":"10.3233\/BMR-230381_ref28","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1016\/j.spinee.2021.02.021","article-title":"Endplate volumetric bone mineral density is a predictor for cage subsidence following lateral lumbar interbody fusion: a risk factor analysis","volume":"21","author":"Jones","year":"2021","journal-title":"The Spine Journal"},{"issue":"6","key":"10.3233\/BMR-230381_ref29","doi-asserted-by":"publisher","first-page":"E683","DOI":"10.1097\/BSD.0000000000000315","article-title":"The correlation between cage subsidence, bone mineral density, and clinical results in posterior lumbar interbody fusion","volume":"30","author":"Oh","year":"2017","journal-title":"Clinical Spine Surgery"},{"issue":"6","key":"10.3233\/BMR-230381_ref30","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1016\/j.jos.2018.06.009","article-title":"Effect of osteoporosis on the clinical and radiological outcomes following one-level posterior lumbar interbody fusion","volume":"23","author":"Cho","year":"2018","journal-title":"Journal of Orthopaedic Science"},{"issue":"3","key":"10.3233\/BMR-230381_ref31","doi-asserted-by":"publisher","first-page":"484","DOI":"10.4184\/asj.2017.11.3.484","article-title":"Bisphosphonate\u2019s and Intermittent Parathyroid Hormone\u2019s Effect on Human Spinal Fusion: A Systematic Review of the Literature","volume":"11","author":"Stone","year":"2017","journal-title":"Asian Spine J"},{"issue":"13","key":"10.3233\/BMR-230381_ref32","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1097\/BRS.0000000000003426","article-title":"Weekly Teriparatide Versus Bisphosphonate for Bone Union During 6 Months After Multi-Level Lumbar Interbody Fusion for Osteoporotic Patients","volume":"45","author":"Oba","year":"2020","journal-title":"Spine (Phila Pa 1976)"},{"issue":"4","key":"10.3233\/BMR-230381_ref33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.14245\/kjs.2014.11.4.221","article-title":"Influence of alendronate and endplate degeneration to single level posterior lumbar spinal interbody fusion","volume":"11","author":"Kim","year":"2014","journal-title":"Korean J Spine."},{"issue":"1","key":"10.3233\/BMR-230381_ref34","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/01.NPR.0000391178.47878.73","article-title":"Denosumab (Prolia): a new option in the treatment of osteoporosis","volume":"36","author":"Belavic","year":"2011","journal-title":"Nurse Pract"},{"issue":"1","key":"10.3233\/BMR-230381_ref36","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bone.2010.10.161","article-title":"Clinical development of anti-RANKL therapies for treatment and prevention of bone metastasis","volume":"48","author":"Lipton","year":"2011","journal-title":"Bone."},{"issue":"4","key":"10.3233\/BMR-230381_ref37","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1210\/jc.2010-1502","article-title":"Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass","volume":"96","author":"Bone","year":"2011","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of Back and Musculoskeletal Rehabilitation"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/BMR-230381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T13:27:55Z","timestamp":1777382875000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/BMR-230381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":36,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3233\/bmr-230381","relation":{},"ISSN":["1878-6324","1053-8127"],"issn-type":[{"value":"1878-6324","type":"electronic"},{"value":"1053-8127","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9,3]]}}}