{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:36:57Z","timestamp":1777466217208,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMR"],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:p>BACKGROUND: In China, Tongluo-Qutong rubber plaster (TQRP) is commonly used for cervical spondylotic radiculopathy, but lacks high-quality trials. OBJECTIVE: This study aimed to conduct a multicenter, open-label, parallel-group, randomized controlled trial in China to investigate the practical efficacy and safety of TQRP in the treatment of CSR. METHODS: A total of 240 patients diagnosed with CSR were recruited for the investigation from multiple hospitals in Gansu province, China. The patients were randomly assigned to either an experimental or a control group. The experimental group received treatment with TQRP, whereas the control group was administered a diclofenac sodium patch (DSP) for a maximum duration of 21 days. The visual analogue scale (VAS) score for pain, the proportion of patients experiencing 50% or more pain relief, the neck disability index (NDI), changes as per the Eaton trial, and recurrence during the follow-up period were evaluated for both groups. The safety and adverse events associated with the concurrent drug therapy were also evaluated. RESULTS: At each time point, the mean VAS and NDI scores of both groups demonstrated a downward trend. The experimental group exhibited a greater decline in VAS score at each time point compared to the control group (P&lt; 0.01). In the Eaton trial, both the percentage of patients experiencing pain relief of 50% or more and the number of abnormal results exhibited improvement. However, the outcomes in the 21 \u00b1 3d experimental group were significantly superior to those in the control group (P&lt; 0.01). During the follow-up period, the recurrence events in the experimental group were reduced compared to the control group. The difference between the two groups was statistically significant (P&lt; 0.05). The incidence of adverse reactions was 1.74% for TQRP and 3.54% for DSP. CONCLUSION: TQRP is effective and safe in the treatment of CSR.<\/jats:p>","DOI":"10.3233\/bmr-230431","type":"journal-article","created":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T09:27:14Z","timestamp":1722590834000},"page":"1591-1599","source":"Crossref","is-referenced-by-count":0,"title":["A multicenter, open-label, parallel-group, randomized controlled trial of Tongluo-Qutong rubber plaster for the treatment of cervical spondylotic radiculopathy"],"prefix":"10.1177","volume":"37","author":[{"given":"Xing-Wen","family":"Xie","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China"},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Xiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Tianshui City Hospital of Traditional Chinese Medicine, Tianshui, China"},{"name":"Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong-Hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Northwest University for Nationalities, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianshui City Hospital of Traditional Chinese Medicine, Tianshui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ding-Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Northwest University for Nationalities, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"8","key":"10.3233\/BMR-230431_ref1","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1177\/21925682221075290","article-title":"Management of Cervical Spondylotic Radiculopathy: A Systematic review","volume":"12","author":"Luyao","year":"2022","journal-title":"Global Spine J."},{"issue":"3","key":"10.3233\/BMR-230431_ref2","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1136\/jnnp.57.3.257","article-title":"Management of cervical spondylotic myelopathy and radiculopathy","volume":"57","author":"Braakman","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"1","key":"10.3233\/BMR-230431_ref3","doi-asserted-by":"publisher","first-page":"56","DOI":"10.3171\/2022.7.SPINE22592","article-title":"Prediction of 2-year clinical outcome trajectories in patients undergoing anterior cervical discectomy and fusion for spondylotic radiculopathy","volume":"38","author":"H\u00e9bert","year":"2022","journal-title":"J Neurosurg Spine."},{"issue":"8","key":"10.3233\/BMR-230431_ref4","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1016\/j.spinee.2014.02.032","article-title":"The course and prognostic factors of symptomatic cervical disc herniation with radiculopathy: a systematic review of the literature","volume":"14","author":"Wong","year":"2014","journal-title":"Spine J."},{"issue":"1","key":"10.3233\/BMR-230431_ref5","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1468-1331.2008.02365.x","article-title":"Degenerative cervical radiculopathy: diagnosis and conservative treatment","volume":"16","author":"Kuijper","year":"2009","journal-title":"A review. 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