{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T12:37:02Z","timestamp":1777466222448,"version":"3.51.4"},"reference-count":40,"publisher":"SAGE Publications","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMR"],"published-print":{"date-parts":[[2024,11,8]]},"abstract":"<jats:p>BACKGROUND: During pregnancy, structural and functional changes usually occur in the body, which has various consequences, including lower back pain (LBP) and hypothyroidism. One of the risk factors for these problems is physical inactivity. OBJECTIVE: This study aimed to investigate the association of back pain and physical inactivity, weight gain, and hypothyroidism in pregnant women. METHODS: In this cohort study, 420 pregnant women (26.333 \u00b1 5.820 years old) were included. At first, participants answered this question: \u201cDo you have any plans for pregnancy in the next month?\u201d If the answer was yes, further evaluations were performed. The physical activity and pain intensity were measured by the International Physical Activity Questionnaire Short Form (IPAQ-S) and Visual Analogue Scale. Serum TSH was measured by automated chemiluminescence and commercial kits. Measurements were conducted before, the first, second, and third trimester of pregnancy. RESULTS: Women reporting LBP were less engaged in physical activities and weight gained in the second and third trimesters of pregnancy was significantly higher than pregnant women without LBP (p&lt; 0.05). TSH level and weight gained in pregnant women with low physical activity level was significantly higher than pregnant women with moderate and high physical activity (p&lt; 0.05) (without significant difference in TSH and BMI). The physical inactivity (before: OR: 1.11 95% CI: 0.89 to 1.22; first trimester: OR: 1.09 95% CI: 1.02 to 1.59; second trimester: OR: 0.92 95% CI: 0.87 to 1.31; third trimester: OR: 1.12 95% CI: 1.02 to 1.39), TSH (OR: 0.85 95% CI: 0.57 to 1.29), and weight gain (second trimester: OR: 0.87 95% CI: 0.92 to 1.59; third trimester: OR: 1.44 95% CI: 1.02 to 1.98; p&lt; 0.05) did predict increased pain intensity. CONCLUSION: Using health-oriented approaches to increase physical activity and normalize thyroid function and weight gain during pregnancy can have beneficial effects on LBP.<\/jats:p>","DOI":"10.3233\/bmr-240086","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T11:44:06Z","timestamp":1720179846000},"page":"1663-1671","source":"Crossref","is-referenced-by-count":3,"title":["The association of back pain with physical inactivity and hypothyroidism in pregnant women"],"prefix":"10.1177","volume":"37","author":[{"given":"Chencui","family":"Shi","sequence":"first","affiliation":[{"name":"Physical Examination Center, Danyang Maternal and Child Health Hospital, Zhenjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangdong","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taian Central Hospital, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shaanxi Provincial Rehabilitation Hospital, Xi\u2019an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/BMR-240086_ref1","first-page":"266","article-title":"Low back pain during pregnancy","volume":"67","author":"Carvalho","year":"2017","journal-title":"Revista Brasileira De Anestesiologia."},{"issue":"6","key":"10.3233\/BMR-240086_ref2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.pmn.2020.05.001","article-title":"Characteristics of low back pain in pregnancy, risk factors, and its effects on quality of life","volume":"21","author":"Berber","year":"2020","journal-title":"Pain Management Nursing."},{"issue":"3","key":"10.3233\/BMR-240086_ref3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3803\/EnM.2016.31.3.386","article-title":"Update on the management of thyroid disease during pregnancy","volume":"31","author":"Yim","year":"2016","journal-title":"Endocrinology and Metabolism."},{"issue":"12","key":"10.3233\/BMR-240086_ref4","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1089\/thy.2004.14.1084","article-title":"Trimester-specific changes in maternal thyroid hormone, thyrotropin, and thyroglobulin concentrations during gestation: trends and associations across trimesters in iodine sufficiency","volume":"14","author":"Soldin","year":"2004","journal-title":"Thyroid."},{"issue":"10","key":"10.3233\/BMR-240086_ref5","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nrendo.2017.93","article-title":"Thyroid disease in pregnancy: new insights in diagnosis and clinical management","volume":"13","author":"Korevaar","year":"2017","journal-title":"Nature Reviews Endocrinology."},{"issue":"3","key":"10.3233\/BMR-240086_ref6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S2213-8587(13)70109-8","article-title":"Hypothyroidism in pregnancy","volume":"1","author":"Teng","year":"2013","journal-title":"The lancet Diabetes & Endocrinology."},{"key":"10.3233\/BMR-240086_ref7","first-page":"1","article-title":"Consequences of undertreatment of hypothyroidism","author":"Feldt-Rasmussen","year":"2023","journal-title":"Endocrine."},{"key":"10.3233\/BMR-240086_ref8","doi-asserted-by":"crossref","unstructured":"Alsubaie SF, Alkathiry AA, Aljuaid MI, Alnasser MA. 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