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The evidence is clear that voluntary exercise in rats and mice can lead to increases in hippocampal neurogenesis and enhanced synaptic plasticity which ultimately result in improved performance in hippocampal-dependent tasks. Furthermore, in models of neurological disorders, including fetal alcohol spectrum disorders, traumatic brain injury, stroke, and neurodegenerative disorders including Alzheimer\u2019s, Parkinson\u2019s and Huntington\u2019s disease exercise can also elicit beneficial effects on hippocampal function. Ultimately this review highlights the multiple benefits of exercise on hippocampal function in both the healthy and the diseased brain.<\/jats:p>","DOI":"10.3233\/bpl-150016","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T08:35:18Z","timestamp":1455525318000},"page":"97-127","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":56,"title":["The Benefits of Exercise on Structural and Functional Plasticity in the Rodent Hippocampus of Different Disease Models"],"prefix":"10.3233","volume":"1","author":[{"given":"Anna R.","family":"Patten","sequence":"first","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Yu","family":"Yau","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine J.","family":"Fontaine","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Meconi","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan C.","family":"Wortman","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian R.","family":"Christie","sequence":"additional","affiliation":[{"name":"Division of Medical Sciences, Island Medical Program, University of Victoria, Victoria, British Columbia, Canada"},{"name":"Department of Biology, University of Victoria, Victoria, British Columbia, Canada"},{"name":"Brain Research Centre and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada"},{"name":"Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_3_1_2_2","unstructured":"Anderson P Morris R Amaral D Bliss T O\u2019Keefe J. 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