{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:50:14Z","timestamp":1790355014259,"version":"4.1.0"},"reference-count":58,"publisher":"IOS Press","issue":"1","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain Plasticity"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:p>\n                    Exercise can improve cognitive function and the outcome of neurodegenerative diseases, like Alzheimer\u2019s disease. This effect has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Recently, we have reported a PGC-1\n                    <jats:italic toggle=\"yes\">\u03b1<\/jats:italic>\n                    -FNDC5\/irisin pathway, which is activated by exercise in the hippocampus in mice and induces a neuroprotective gene program, including\n                    <jats:italic toggle=\"yes\">Bdnf<\/jats:italic>\n                    . This review will focus on FNDC5 and its secreted form \u201cirisin\u201d, a newly discovered myokine, and their role in the nervous system and its therapeutic potential. In addition, we will briefly discuss the role of other exercise-induced myokines on positive brain effects.\n                  <\/jats:p>","DOI":"10.3233\/bpl-150019","type":"journal-article","created":{"date-parts":[[2016,2,15]],"date-time":"2016-02-15T08:34:14Z","timestamp":1455525254000},"page":"55-61","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":150,"title":["FNDC5\/Irisin \u2013 Their Role in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain"],"prefix":"10.3233","volume":"1","author":[{"given":"Christiane D.","family":"Wrann","sequence":"first","affiliation":[{"name":"Dana-Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.051"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","unstructured":"Ahlskog JE 2011 Does vigorous exercise have a neuroprotective effect in Parkinson disease? 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