{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T05:56:29Z","timestamp":1786946189943,"version":"build-2736575974"},"reference-count":96,"publisher":"IOS Press","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Brain Plasticity"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Fetal alcohol spectrum disorders (FASDs) are associated with a wide range of cognitive deficiencies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We previously  found that gestational exposure to moderate levels of alcohol in mice throughout the 1st-2nd human trimester-equivalents  for brain development results in profound impairment of the hippocampal neurogenic response to enriched environment (EE) in adulthood, without altering baseline neurogenesis rate under standard housing (SH). However, the functional and  structural consequences of impaired EE-mediated neurogenesis in the context of prenatal alcohol exposure (PAE) have  not been determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Here, we demonstrate that PAE-EE mice display impaired performance on a neurogenesis-dependent  pattern discrimination task, broadened behavioral activation of the dentate gyrus, as assessed by expression of the immediate  early gene, c-Fos, and impaired dendritic branching of adult-generated dentate granule cells (aDGCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>These studies further underscore the impact of moderate gestational alcohol exposure on adult hippocampal plasticity and support adult hippocampal neurogenesis as a potential therapeutic target to remediate certain neurological outcomes in FASD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/bpl-200112","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T09:41:21Z","timestamp":1605865281000},"page":"67-82","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Functional and Structural Correlates of Impaired Enrichment-Mediated Adult Hippocampal Neurogenesis in a Mouse Model of Prenatal Alcohol Exposure"],"prefix":"10.3233","volume":"6","author":[{"given":"Kymberly","family":"Gustus","sequence":"first","affiliation":[{"name":"University of New Mexico School of Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"University of New Mexico School of Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie","family":"Newville","sequence":"additional","affiliation":[{"name":"University of New Mexico School of Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee Anna","family":"Cunningham","sequence":"additional","affiliation":[{"name":"University of New Mexico School of Medicine","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"7437","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/add.14841"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3319"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6437a3"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-011-9170-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"crossref","unstructured":"PetrelliBWeinbergJHicksGG. 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