{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:19:37Z","timestamp":1777479577602,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Cancer Biomarkers"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The role of adopokines in adrenal tumors\u2019 hormonal activity remains unclear. Obesity may induce arterial hypertension, disorders of carbohydrate metabolism, and is a risk factor of cardiovascular disease. In patients with subclinical hormone secretion by the adrenal cortex or medulla the risk of metabolic disease is increased.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE:<\/jats:title>\n                    <jats:p>Authors of this retrospective study selected 78 patients with subclinical hormone secretion out of all adrenal incidentaloma patients hospitalized in the Department of Endocrinology and Internal Medicine between 1995 and 2014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>The analyzed group comprised of 38 subclinical Cushing\u2019s syndrome (SCS), 40 incidentally discovered pheochromocytoma (PHEO) and 42 patients operated due to an adrenal tumor without pathological hormonal activity. Expression of adiponectin (AdipoR1, AdipoR2) and leptin (Ob-R) receptors in adrenal tumors was assessed in relation to body mass index (BMI) and hormonal activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We found statistically significant negative correlations between BMI and expression of all examined receptors in SCS patients (AdipoR1:\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"p=\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mi>p<\/mml:mi>\n                            <mml:mo>=<\/mml:mo>\n                            <mml:mi\/>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      0.032; AdipoR2:\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"p&lt;\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mi>p<\/mml:mi>\n                            <mml:mo>&lt;<\/mml:mo>\n                            <mml:mi\/>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      0.001; leptin Ob-R:\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"p=\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mi>p<\/mml:mi>\n                            <mml:mo>=<\/mml:mo>\n                            <mml:mi\/>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      0.001). In PHEOs, BMI correlated negatively only with AdipoR2 (\n                      <jats:inline-formula>\n                        <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" alttext=\"p=\" display=\"inline\" overflow=\"scroll\">\n                          <mml:mrow>\n                            <mml:mi>p<\/mml:mi>\n                            <mml:mo>=<\/mml:mo>\n                            <mml:mi\/>\n                          <\/mml:mrow>\n                        <\/mml:math>\n                      <\/jats:inline-formula>\n                      0.014).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Data obtained show that the most significant factor associated with the expression of AdipoR1, AdipoR2 and leptin Ob-R receptors in the adrenal tumor tissue is BMI, not their hormonal activity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/cbm-171049","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T11:46:52Z","timestamp":1523965612000},"page":"325-332","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Expression of adiponectin and leptin receptors in adrenal incidentaloma patients with subclinical hormone secretion"],"prefix":"10.1177","volume":"22","author":[{"given":"Anna","family":"Babi\u0144ska","sequence":"first","affiliation":[{"name":"Medical University of Gdansk","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafa\u0142","family":"P\u0229ksa","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"\u015awia\u0327tkowska-Stodulska","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Wi\u015bniewski","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Sworczak","sequence":"additional","affiliation":[{"name":"Medical University of Gdansk","place":["Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2018,5]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24665"},{"key":"e_1_3_3_3_2","first-page":"98","article-title":"Hormonal activity in clinically silent adrenal incidentaloma,","volume":"8","author":"Babinska A.","year":"2012","unstructured":"BabinskaA. Siekierska-HellmannM. BlautK. LewczukA. Wi\u015bniewskiP. Gnaci\u0144skaM. Obo\u0142o\u0144czykL. Swia\u0327tkowska-StodulskaR. and SworczakK., Hormonal activity in clinically silent adrenal incidentaloma, Arch Med Sci 8 (2012), 98\u2013103.","journal-title":"Arch Med Sci"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(99)90047-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-010-0017-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1015"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8519362"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2010.03.011"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.12.018"},{"issue":"2","key":"e_1_3_3_10_2","first-page":"160","article-title":"Adipose tissue activity in relation to overweight or obesity","volume":"61","author":"Gnacinska M.","year":"2010","unstructured":"GnacinskaM. MalgorzewiczS. GuzekM. Lysiak-SzydlowskaW. and SworczakK., Adipose tissue activity in relation to overweight or obesity, Endokrynol Pol 61(2) (2010), 160\u2013168.","journal-title":"Endokrynol Pol"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-009-0035-2"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.27.9935"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.No885"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI29126"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2013.08.006"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2274"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.976"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7696(07)63002-2"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2010.03794.x"},{"key":"e_1_3_3_20_2","first-page":"975","article-title":"Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas","volume":"17","author":"Rossi G.P.","year":"2006","unstructured":"RossiG.P. SticchiD. GiulianiL. BernanteP. ZavattieroS. PessinaA.C. and NussdorferG.G., Adiponectin receptor expression in the human adrenal cortex and aldosterone-producing adenomas, Int J Mol Med 17 (2006), 975\u2013980.","journal-title":"Int J Mol Med"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ14-0539"},{"key":"e_1_3_3_22_2","first-page":"330","article-title":"Adipose tissue. Pathophysiology, distribution, sex differences and the role in inflammation and cancerogenesis","volume":"58","author":"Siemi\u0144ska L.","year":"2007","unstructured":"Siemi\u0144skaL., Adipose tissue. 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