{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:20:16Z","timestamp":1777479616409,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2018,8,20]]},"DOI":"10.3233\/cbm-181215","type":"journal-article","created":{"date-parts":[[2018,6,15]],"date-time":"2018-06-15T12:57:52Z","timestamp":1529067472000},"page":"709-719","source":"Crossref","is-referenced-by-count":8,"title":["The KISS1 gene overexpression as a potential molecular marker for cervical cancer cells"],"prefix":"10.1177","volume":"22","author":[{"given":"Keiko","family":"Taniguchi-Ponciano","sequence":"first","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"},{"name":"Programa de Doctorado en Ciencias en Biomedicina y Biotecnolog\u00eda Molecular, Departamento de Microbiolog\u00eda, Escuela de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional (ENCB-IPN), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Mar\u00eda","family":"Ribas-Aparicio","sequence":"additional","affiliation":[{"name":"Programa de Doctorado en Ciencias en Biomedicina y Biotecnolog\u00eda Molecular, Departamento de Microbiolog\u00eda, Escuela de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional (ENCB-IPN), Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Marrero-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"},{"name":"Laboratorio 5 Departamento de Biomedicina Molecular, CINVESTAV-IPN, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Arreola-De la Cruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edctor","family":"Huerta-Padilla","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"G\u00f3mez-Ortiz","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo","family":"Ponce-Navarrete","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Rodr\u00edguez-Esquivel","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Mendoza-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"},{"name":"Universidad Polit\u00e9cnico de Huatusco, Huatusco, Veracruz, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"G\u00f3mez-Virgilio","sequence":"additional","affiliation":[{"name":"Laboratorio 5 Departamento de Biomedicina Molecular, CINVESTAV-IPN, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Peralta","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Din\u00e1mica Celular, Universidad Aut\u00f3noma del Estado de Morelos, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Serna","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Displasias, Hospital General de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Displasias, Hospital General de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Cl\u00ednica de Displasias, Hospital General de M\u00e9xico, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Servicio de Patolog\u00eda, Hospital de Oncolog\u00eda CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Laboratorios de Vigilancia e Investigaci\u00f3n Epidemiol\u00f3gica, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngeles","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Divisi\u00f3n de Laboratorios de Vigilancia e Investigaci\u00f3n Epidemiol\u00f3gica, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"Bandala","sequence":"additional","affiliation":[{"name":"Unidad de Apoyo a la Investigaci\u00f3n, Instituto Nacional de Rehabilitaci\u00f3n, Secretar\u00eda de Salud, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Laboratorio de Oncolog\u00eda Gen\u00f3mica, Unidad de Investigaci\u00f3n M\u00e9dica en Enfermedades Oncol\u00f3gicas, Hospital de Oncolog\u00eda, CMN-SXXI, IMSS, Mexico City, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"1","key":"10.3233\/CBM-181215_ref3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc2050","article-title":"The natural history of cervical HPV infection: Unresolved issues","volume":"7","author":"Woodman","year":"2007","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"10.3233\/CBM-181215_ref4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmark of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.3233\/CBM-181215_ref5","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1055\/s-2007-1016235","article-title":"Embryo implantation and tumor metastasis: Common pathways of invasion and angiogenesis","volume":"17","author":"Murray","year":"1999","journal-title":"Semin Reprod Endocrinol"},{"issue":"8","key":"10.3233\/CBM-181215_ref6","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1242\/jcs.00971","article-title":"Kisspeptin-10 a KISS-1\/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts","volume":"117","author":"Bilban","year":"2004","journal-title":"J Cell Sci"},{"key":"10.3233\/CBM-181215_ref7","first-page":"19","article-title":"Cancer is a somatic cell pregnancy","volume":"7","author":"Old","year":"2007","journal-title":"Cancer Immun"},{"issue":"11","key":"10.3233\/CBM-181215_ref8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and pregnancy: Parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents","volume":"84","author":"Holtan","year":"2009","journal-title":"Mayo Clin Proc"},{"key":"10.3233\/CBM-181215_ref9","doi-asserted-by":"crossref","unstructured":"Z. Rasoulzadeh, R. Ghods, T. Kazemi et al., Placental kisspeptins differentially modulate vital parameters of estrogen receptor-positive and -negative breast cancer cells, PLoS ONE 11(4) (2016).","DOI":"10.1371\/journal.pone.0153684"},{"issue":"4","key":"10.3233\/CBM-181215_ref10","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.mayocp.2014.01.006","article-title":"Immunomodulatory effects of sex hormones: Requirements for pregnancy and relevance in melanoma","volume":"89","author":"Enninga","year":"2014","journal-title":"Mayo Clin Proc"},{"key":"10.3233\/CBM-181215_ref11","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1093\/jnci\/88.23.1731","article-title":"KISS-1, a novel human malignant melanoma metastasis-suppressor gene","volume":"88","author":"Lee","year":"1996","journal-title":"J Natl Cancer Inst"},{"key":"10.3233\/CBM-181215_ref12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.bbrc.2004.01.021","article-title":"Metastin and its variant forms suppress migration of pancreatic cancer cells","volume":"315","author":"Masui","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"10.3233\/CBM-181215_ref13","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1349-7006.2006.00136.x","article-title":"Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2\u2032-deoxycytidine treatment and oligonucleotide microarray","volume":"97","author":"Yamashita","year":"2006","journal-title":"Cancer Sci"},{"issue":"2","key":"10.3233\/CBM-181215_ref14","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ajpath.2011.05.009","article-title":"KISS1 methylation and expression as tumor stratification biomarkers and clinical outcome prognosticators for bladder cancer patients","volume":"179","author":"Cebrian","year":"2011","journal-title":"Am J Pathol"},{"key":"10.3233\/CBM-181215_ref15","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/1471-2164-6-130","article-title":"Characterization of the global profile of gene expressed in cervical epithelium by Serial Analysis of Gene Expression (SAGE)","volume":"6","author":"Perez-Placencia","year":"2005","journal-title":"BMC Genomics"},{"key":"10.3233\/CBM-181215_ref16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/1471-2164-8-142","article-title":"Comprehensive serial analysis of gene expression of the cervical transcriptome","volume":"8","author":"Shadeo","year":"2007","journal-title":"BMC Genomics"},{"key":"10.3233\/CBM-181215_ref17","doi-asserted-by":"crossref","unstructured":"D. Marrero-Rodr\u00edguez, K. Taniguchi-Ponciano, F. Jim\u00e9nez-Vega et al., Kr\u00fcppel-like factor 5 as potencial molecular marker in cervical cancer and the KLF family profile expression, Tumor Biol (2014).","DOI":"10.1007\/s13277-014-2380-4"},{"key":"10.3233\/CBM-181215_ref18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative pcr and the 2-\u0394\u2062\u0394\u2062Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.3233\/CBM-181215_ref19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/j.ctrv.2008.05.007","article-title":"The kisspeptin (KISS-1)\/GPR54 system in cancer biology","volume":"34","author":"Makri","year":"2008","journal-title":"Cancer Treatment Reviews"},{"key":"10.3233\/CBM-181215_ref20","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0002-9440(10)63854-0","article-title":"Tumor suppressor role of KISS-1 in bladder cancer: Loss of KISS-1 expression is associated with bladder cancer progression and clinical outcome","volume":"162","author":"Sanchez-Carbayo","year":"2003","journal-title":"Am J Pathol"},{"key":"10.3233\/CBM-181215_ref21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10585-005-8186-4","article-title":"KISS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha","volume":"22","author":"Jiang","year":"2005","journal-title":"Clin Exp Metastas"},{"key":"10.3233\/CBM-181215_ref22","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s10585-005-4180-0","article-title":"KISS-1 expression in human breast cancer","volume":"22","author":"Martin","year":"2005","journal-title":"Clin Exp Metastasis"},{"key":"10.3233\/CBM-181215_ref23","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00432-003-0469-z","article-title":"Quantitative reverse transcriptase polymerase chain reaction analysis for KISS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma","volume":"129","author":"Ikeguchi","year":"2003","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.3233\/CBM-181215_ref24","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2407-7-226","article-title":"Genomic imbalances in 5918 malignant epithelial tumors: An explorative meta-analysis of chromosomal CGH data","volume":"7","author":"Baudis","year":"2007","journal-title":"BMC Cancer"},{"issue":"29","key":"10.3233\/CBM-181215_ref25","doi-asserted-by":"crossref","first-page":"10071","DOI":"10.3748\/wjg.v20.i29.10071","article-title":"KISS1 methylation and expression as predicators of disease progression in colorectal cancer patients","volume":"20","author":"Qin-Chen","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.3233\/CBM-181215_ref26","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35079135","article-title":"Metastasis suppressor gene KISS-1 encodes peptide ligand of a G-proteincoupled receptor","volume":"411","author":"Ohtaki","year":"2001","journal-title":"Nature"},{"key":"10.3233\/CBM-181215_ref27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1262\/jrd.18146","article-title":"Involvement of anteroventral periventricular metastin\/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats","volume":"53","author":"Adachi","year":"2007","journal-title":"J Reprod Dev"},{"issue":"6","key":"10.3233\/CBM-181215_ref28","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.3892\/ijo.2015.2950","article-title":"Honokiol suppresses metastasis of renal cell carcinoma by targeting KISS1\/KISS1R signaling","volume":"46","author":"Cheng","year":"2015","journal-title":"Int J Oncol"}],"container-title":["Cancer Biomarkers"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CBM-181215","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:06:23Z","timestamp":1777385183000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CBM-181215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,20]]},"references-count":26,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/cbm-181215","relation":{},"ISSN":["1875-8592","1574-0153"],"issn-type":[{"value":"1875-8592","type":"electronic"},{"value":"1574-0153","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8,20]]}}}