{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:18:27Z","timestamp":1780082307782,"version":"3.54.0"},"reference-count":52,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2021,8,24]]},"abstract":"<jats:p>BACKGROUND: Non-Hodgkin\u2019s lymphoma (NHL) is the most common hematological malignancy in the world. Many etiologic factors have been implicated in the risk of developing NHL, including genetic susceptibility and obesity. Single-nucleotide polymorphisms (SNPs) in Ghrelin (GHRL), an anti-inflammatory hormone, and tumor necrosis factor \u03b1 (TNF-\u03b1), an inflammatory cytokine, have been independently associated with the risk for obesity and NHL. OBJECTIVE: To investigate the association between SNPs in GHRL and TNF-\u03b1 and the risk for NHL and obesity in Kuwaitis. METHODS: We recruited 154 Kuwaiti NHL patients and 217 controls. Genotyping was performed for rs1629816 (GHRL promoter region), rs35684 (GHRL 3\u2019 untranslated region), and rs1800629 (TNF-\u03b1 promoter region). Logistic regression analysis was performed to assess the association of the investigated SNPs with NHL and the relationship between the selected SNPs with BMI in each group separately. RESULTS: We show that rs1629816 GG was associated with an increased risk for NHL in our sample (p= 0.0003, OR 1.82; CI: 1.31\u20132.54). None of the investigated SNPs were associated with obesity, nor was obesity found to be associated with the risk for NHL. CONCLUSIONS: Our study demonstrates an association between rs1629816, a SNP in the GHRL regulatory region, and NHL in Kuwaitis.<\/jats:p>","DOI":"10.3233\/cbm-200373","type":"journal-article","created":{"date-parts":[[2021,5,18]],"date-time":"2021-05-18T13:21:29Z","timestamp":1621344089000},"page":"11-18","source":"Crossref","is-referenced-by-count":1,"title":["Association analysis of genetic variants in the ghrelin and tumor necrosis factor \u03b1 genes and the risk for non-Hodgkin\u2019s lymphoma in Kuwaitis"],"prefix":"10.1177","volume":"32","author":[{"given":"Maryam H.","family":"Alrashid","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Al-Serri","sequence":"additional","affiliation":[{"name":"Department of Pathology, Unit of Human Genetics, Faculty of Medicine, Kuwait University, Safat, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salem H.","family":"Alshemmari","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait"},{"name":"Kuwait Cancer Control Center, Kuwait City, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeethu Anu","family":"Geo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne A.","family":"Al-Bustan","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, Kuwait University, Safat, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/CBM-200373_ref1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1177\/0003319709333226","article-title":"Prevalence of overweight, 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Res"},{"key":"10.3233\/CBM-200373_ref40","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1158\/1055-9965.EPI-06-0573","article-title":"A case-control investigation of immune function gene polymorphisms and risk of testicular germ cell tumors","volume":"16","author":"Purdue","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.3233\/CBM-200373_ref41","doi-asserted-by":"crossref","first-page":"R393","DOI":"10.1530\/ERC-16-0130","article-title":"Is there an effect of ghrelin\/ghrelin analogs on cancer? 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Wilson, J.A. Symons, T.L. McDowell, H.O. McDevitt and G.W. Duff, Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation, Proc Natl Acad Sci U S A 94 (1997), 3195\u20139.","DOI":"10.1073\/pnas.94.7.3195"},{"key":"10.3233\/CBM-200373_ref49","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/cbf.1736","article-title":"Ghrelin inhibits AGEs-induced apoptosis in human endothelial cells involving ERK1\/2 and PI3K\/Akt pathways","volume":"29","author":"Xiang","year":"2011","journal-title":"Cell Biochem Funct"},{"key":"10.3233\/CBM-200373_ref50","first-page":"1387","article-title":"Acylated and unacylated ghrelin inhibit apoptosis in myoblasts cocultured with colon carcinoma cells","volume":"39","author":"Zeng","year":"2018","journal-title":"Oncol Rep"},{"key":"10.3233\/CBM-200373_ref51","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.3390\/ijms15057684","article-title":"Different role of tumor necrosis factor-alpha polymorphism in non-Hodgkin lymphomas among Caucasian and Asian populations: a meta-analysis","volume":"15","author":"Zhai","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.3233\/CBM-200373_ref52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1440-1843.2010.01879.x","article-title":"Association between the tumour necrosis factor-alpha-308G\/A polymorphism and chronic obstructive pulmonary disease: an update","volume":"16","author":"Zhang","year":"2011","journal-title":"Respirology"},{"key":"10.3233\/CBM-200373_ref53","doi-asserted-by":"crossref","first-page":"e37846","DOI":"10.1371\/journal.pone.0037846","article-title":"Tumor necrosis factor-alpha induced protein 8 polymorphism and risk of non-Hodgkin\u2019s lymphoma in a Chinese population: a case-control study","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.3233\/CBM-200373_ref54","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tox.2007.05.013","article-title":"Ghrelin inhibit cell apoptosis in pancreatic beta cell line HIT-T15 via mitogen-activated protein kinase\/phosphoinositide 3-kinase pathways","volume":"237","author":"Zhang","year":"2007","journal-title":"Toxicology"}],"container-title":["Cancer Biomarkers"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/CBM-200373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:08:14Z","timestamp":1777385294000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/CBM-200373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":52,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/cbm-200373","relation":{},"ISSN":["1875-8592","1574-0153"],"issn-type":[{"value":"1875-8592","type":"electronic"},{"value":"1574-0153","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8,24]]}}}