{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:25:23Z","timestamp":1782289523936,"version":"3.54.5"},"reference-count":41,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CBM"],"published-print":{"date-parts":[[2021,6,18]]},"abstract":"<jats:p>BACKGROUND: MicroRNAs (miRNAs), with noticeable stability and unique expression pattern in plasma of patients with various diseases, are powerful non-invasive biomarkers for cancer detection including endometrial cancer (EC). OBJECTIVE: The objective of this study was to identify promising miRNA biomarkers in plasma to assist the clinical screening of EC. METHODS: A total of 93 EC and 79 normal control (NC) plasma samples were analyzed using Quantitative Real-time Polymerase Chain Reaction (qRT-PCR) in this four-stage experiment. The receiver operating characteristic curve (ROC) analysis was conducted to evaluate the diagnostic value. Additionally, the expression features of the identified miRNAs were further explored in tissues and plasma exosomes samples. RESULTS: The expression of miR-142-3p, miR-146a-5p, and miR-151a-5p was significantly overexpressed in the plasma of EC patients compared with NCs. Areas under the ROC curve of the 3-miRNA signature were 0.729, 0.751, and 0.789 for the training, testing, and external validation phases, respectively. The diagnostic performance of the identified signature proved to be stable in the three public datasets and superior to the other miRNA biomarkers in EC diagnosis. Moreover, the expression of miR-151a-5p was significantly elevated in EC plasma exosomes. CONCLUSIONS: A signature consisting of 3 plasma miRNAs was identified and showed potential for the non-invasive diagnosis of EC.<\/jats:p>","DOI":"10.3233\/cbm-200972","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T17:00:38Z","timestamp":1618938038000},"page":"127-138","source":"Crossref","is-referenced-by-count":27,"title":["Three plasma-based microRNAs as potent diagnostic biomarkers for endometrial cancer"],"prefix":"10.1177","volume":"31","author":[{"given":"Xingchen","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minmin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"},{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfang","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Northern Jiangsu People\u2019s Hospital, Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/CBM-200972_ref1","first-page":"527","article-title":"Clinical and morphological correlations in early diagnosis of endometrial cancer","volume":"59","author":"Neac\u015fu","year":"2018","journal-title":"Romanian Journal of Morphology and Embryology = Revue Roumaine de Morphologie et Embryologie"},{"key":"10.3233\/CBM-200972_ref2","doi-asserted-by":"crossref","unstructured":"C.M. 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